Mesotherapy in Czechia

Skin and scalp rejuvenation using the patient's own platelet-rich plasma (PRP), prepared from a small venous blood draw and reinjected into the face, neck, décolletage, hands or scalp. PRP contains concentrated growth factors — PDGF, TGF-beta, VEGF and IGF — that stimulate collagen synthesis, improve tissue quality and, on the scalp, support follicular activity. Because the plasma is autologous, rejection and allergic reactions are not a concern. DermaMedEst's protocol draws 20 ml of blood, centrifuges it to concentrate platelets, and injects the resulting plasma into the target area.

Polynucleotide biostimulation with PDRN (polydeoxyribonucleotide) at DiVine Clinic uses salmon-derived DNA fragments to activate dormant skin cells, stimulate collagen and elastin production, and restore elasticity, firmness, and hydration. Administered by MUDr. Petra Moravcová, PDRN is injected into the target skin zone — eye area, face, or neck and décolletage — where it acts on A2A adenosine receptors to trigger cell proliferation and tissue remodelling pathways. The treatment is an injectable biostimulator rather than a filler — it does not add visible volume but instead improves the quality of the skin's own structural matrix. DiVine Clinic offers courses of three sessions for each zone, with the eye area priced at 6,500 Kč and the face or neck at 8,500 Kč per session. Results are gradual and progressive, with visible improvement in skin elasticity, tone, and firmness over 4–8 weeks per session.

Plasma therapy (PRP) at DiVine Clinic uses the patient's own platelet-rich plasma to stimulate skin regeneration, collagen production, and tissue repair. MUDr. Petra Moravcová draws 8–10 ml of venous blood, centrifuges it to isolate the platelet-rich plasma fraction concentrated with growth factors, and re-injects the PRP into the target skin zone via fine needles or cannulas after numbing cream application. The growth factors released from activated platelets — PDGF, TGF-β, and VEGF — recruit fibroblasts to produce new collagen and elastin and improve local vascularisation. Because PRP is derived from the patient's own blood, the risk of allergy or immune reaction is essentially zero. The treatment is used at DiVine Clinic for facial skin rejuvenation, improved skin radiance, acne improvement, and hair loss treatment. Collagen remodelling begins below the surface within days, with visible skin quality improvement appearing over 6–8 weeks.

Biorevitalization at S-thetics Beauty delivers unsaturated (non-cross-linked) hyaluronic acid directly into the dermis via fine-needle micro-injections to intensely hydrate and rejuvenate the skin from within. Unlike structural fillers, biorevitalization HA is low-viscosity and spreads through the tissue to act as a water reservoir — binding up to 1,000 times its own weight in water and stimulating fibroblast activity for improved collagen and elastin production. The result is improved skin quality: better hydration, finer pores, increased elasticity, and a natural glow that no topical moisturiser can replicate at the same depth. MDDr. Darina Šanšašvili performs the procedure using a series of small superficial injections across the face, neck, or décolletage. A series of three sessions two to four weeks apart is recommended for cumulative benefit; single sessions are also available for those who want a skin-quality boost before an event.

An injectable rejuvenation treatment in which collagen is applied into the skin to restore quality, firmness and a fresher appearance. At Estemedic collagen biorevitalisation is part of MUDr. Ilona Karasová's pro-ageing programme, aimed at improving overall skin condition rather than filling a single wrinkle. It supports the skin's own structural framework — the protein network that gives skin its firmness and that naturally declines with age — and is suited to skin that is losing firmness, looking dull or showing early signs of ageing. Delivered through a series of fine injections, results build gradually and are usually best as a short course of sessions. Pricing starts from 6,500 Kč, finalised at consultation.

Rejuran is a skin rejuvenation treatment using PDRN (polydeoxyribonucleotide) — salmon-derived DNA fragments that are biologically compatible with human tissue. Applied via mesotherapy micro-injections, PDRN activates skin cell repair pathways to rebuild the skin's structural integrity from within. Neo Beauty Clinic documented ten clinical effects: lifting, pore minimisation, pigmentation reduction, texture refinement, tone evening, fine line reduction, skin barrier regeneration, dead cell removal, sebum regulation and confirmed clinical safety. Separate formulations are available for the eye area (Rejuran i) and the full face (Rejuran Healer), with discounted multi-session packages.

PhilArt NEXT is an Austrian medical-grade bio-stimulatory gel combining polynucleotides and hyaluronic acid in a 1:1 ratio, administered by RVmedCentrum physicians using the VIS injection device for precise uniform distribution. It bio-stimulates the mesodermis of the face, neck, décolletage, and hands — as well as stretch marks and acne scars — improving elasticity, hydration, and skin quality. Unlike single-ingredient alternatives, the combined PN-HA formulation provides both structural support and cellular stimulation in a single treatment.

Polynucleotide (PDRN/PN) biostimulation at Medest uses injectable DNA fragments derived from wild Korean salmon milt — highly purified and extensively biocompatibility-tested — to activate the skin's natural repair mechanisms from within. The polynucleotides bind to adenosine receptors in skin cells, triggering a cascade of regenerative processes: increased hydration, improved structural integrity, collagen and elastin stimulation, and measurable anti-inflammatory and antioxidant activity. Unlike hyaluronic acid fillers that add volume mechanically, polynucleotides work biologically — they do not fill or volumise but instead restore the functional quality of skin that has thinned or lost resilience with age. MUDr. Vojtková applies the treatment to the eye area, face, neck, and décolleté with results developing gradually over several weeks.

Injection mesotherapy delivers individually selected cocktails of hyaluronic acid, vitamins, amino acids and antioxidants into the middle skin layer through micro-injections — deeply hydrating, revitalising and improving skin quality where creams cannot reach.

Facial mesotherapy delivers a cocktail of vitamins, peptides and hyaluronic acid into the deeper layers of facial skin through a series of fine microinjections. The nutrients hydrate, nourish and stimulate collagen, improving skin texture, tone and elasticity. At GH Solutions it is performed by a physician as both a rejuvenating treatment and an anti-ageing preventive, with no downtime and a visible freshening of the complexion.

Hair mesotherapy treats thinning hair and shedding by injecting a nourishing cocktail of vitamins, peptides and growth factors directly into the scalp. The microinjections improve blood flow to the follicles, feed them and help reactivate the hair-growth cycle. At GH Solutions it is performed by a physician for both men and women experiencing early hair loss, as a non-surgical way to strengthen existing hair and support new growth.

PRP plasma therapy at FaceExpert uses the patient's own blood — drawn, centrifuged to isolate the platelet-rich plasma fraction, and re-injected into the target tissue — to deliver a concentrated payload of growth factors that stimulate collagen production, improve skin quality, and support tissue regeneration. The treatment is completely autologous: because it uses the patient's own plasma, the risk of allergy or immune reaction is essentially zero. FaceExpert performs PRP with either 1 vial (6,900 Kč) or 2 vials (10,900 Kč) of processed plasma depending on the treatment zone and concentration needed. The therapy is used for facial skin rejuvenation, acne scarring, hair loss on the scalp, and general skin quality enhancement. Growth factors from activated platelets — PDGF, TGF-β, VEGF, EGF — trigger fibroblast proliferation, collagen synthesis, and angiogenesis. Visible improvement in skin luminosity and texture appears over 4–8 weeks per session, with 2–3 sessions recommended for sustained results.

Mesotherapy at Klinika Esthé delivers micro-injections of hyaluronic acid, vitamins and revitalising complexes into the superficial skin layers of the face or eye area to improve hydration, elasticity and overall skin quality. Performed by the clinic's aesthetic medicine physicians, the treatment targets dull, dehydrated or early-ageing skin without altering facial volume or expression, and requires minimal downtime. Sessions cover the face (1 ml or 2 ml product volume) or the delicate eye area, and are commonly delivered as a short series for cumulative biorevitalisation results.

REJURAN is a bio-stimulatory injectable made from polynucleotides (PN) derived from salmon gonad DNA. At RVmedCentrum it is used for facial skin regeneration, under-eye rejuvenation, scar improvement, and hand treatment. The polynucleotide chains stimulate fibroblast activity, increasing collagen and elastin production while reducing inflammation and restoring the skin's barrier function. Three formulations are available: Healer for face and body, I for the delicate eye area, and S for acne scars and other scarring.

Profhilo at Estetika by Medfima is an injectable skin remodelling treatment using one of the highest concentrations of hyaluronic acid available in any injectable product. Unlike conventional HA fillers, Profhilo is not cross-linked — it spreads throughout the tissue in a bio-remodelling action, stimulating the production of four types of collagen and elastin while delivering intense hydration. Two sessions four weeks apart are the standard protocol. Profhilo Structura, the deeper-tissue variant at 9 900 Kč, addresses the superficial musculoaponeurotic system (SMAS) layer for more pronounced tissue firming in clients with more advanced laxity. Results last up to 12 months and are notable for being completely natural — no added volume, no changed expressions.

Profhilo is an injectable bio-remodelling treatment that uses ultra-pure hyaluronic acid in maximum concentration to deeply hydrate the skin and stimulate the cells that make collagen and elastin, firming and refreshing without adding volume. At Dermaestet it is placed at a small number of points from which it spreads through the tissue, and is suited to lax, tired skin on the face, neck, décolletage, arms and above the knees. Because the effect is regenerative, it is usually given as a short course with results building over the weeks afterward.

Profhilo at Skinity Clinic is the highest-concentration HA bioremodelling injectable currently available in Europe — a 64 mg/2 mL formulation of thermally stabilised hyaluronic acid that is not cross-linked in the traditional filler sense. Rather than creating volume or projection, Profhilo disperses through the tissue hydrating, tightening, and remodelling the skin architecture at the cellular level. MUDr. Martin Bortlík administers it using the BAP (bio-aesthetic points) protocol — five anatomically defined injection points per cheek — that distribute the product through the tissue's natural hydraulic pressure. The result is improved skin quality, elasticity, firmness, and a luminous skin tone that emerges progressively over 4–8 weeks as the four types of collagen and elastin stimulation take effect. The standard treatment is 2 sessions 4 weeks apart.

PDRN (polydeoxyribonucleotide) biostimulation uses concentrated DNA fragments extracted from wild salmon and injected via fine needle into the face, neck, décolletage or hands. The DNA extract is biocompatible with human tissue and works by binding to adenosine receptors on skin cells, stimulating fibroblast proliferation and collagen synthesis. Results include visible lifting, tightening, improved skin elasticity, pore minimisation and reduction in dark circles — with improvement from the first session and progressive gains over a course of two to four treatments.

PDRN polynucleotide biostimulation at MEDICOM Clinic Brno, using highly purified DNA fragments derived from salmon sperm to activate fibroblast proliferation, accelerate collagen synthesis, and improve tissue hydration. A regenerative injectable therapy for skin quality rather than volume or wrinkle correction.

An injectable bio-rejuvenation cocktail combining hyaluronic acid with amino acids and peptides to biostimulate and hydrate the skin. At Estemedic MUDr. Ilona Karasová delivers this blend through a series of fine injections to improve overall skin quality — hydration, firmness and tone — as part of the rejuvenation programme. The hyaluronic acid binds water, the amino acids serve as building blocks for the skin's own structural proteins, and the peptides signal and support renewal. Unlike a volumising filler it works across the whole treatment area to refresh the complexion, with results building gradually over the following weeks. Pricing starts from 7,000 Kč, finalised at consultation.

DNA rejuvenation uses polynucleotides derived from purified salmon DNA, injected into the skin to stimulate regeneration, deep hydration and the production of collagen and elastin for improved firmness. It is a gentle microinjection treatment for the face, neck, décolletage and the delicate eye contour, with optional numbing cream for comfort. At Estéea it is offered as a short course of two to four treatments, with results that build over the following weeks and last several months.

Plasma lifting uses a small sample of your own blood, spun in a centrifuge to concentrate its platelets and growth factors, which is then injected to stimulate skin repair and rejuvenation. Estéea's RegenPlazma combines this autologous platelet-rich plasma with hyaluronic acid ("plasmafilling") for added hydration. Because the material comes entirely from you, there are no foreign substances and the clinic describes it as essentially zero-risk. It is used for facial rejuvenation, under-eye circles, nasolabial folds and even hair-loss support, for adults aged 18 and over.

Autologous PRP (platelet-rich plasma) therapy at MEDICOM Clinic Brno, using growth factors concentrated from the patient's own blood to stimulate collagen production, improve skin texture, and support tissue regeneration. A fully biological treatment requiring no synthetic materials.

Jalupro Super Hydro biorevitalization at RAJSKA Clinic combines hyaluronic acid with a proprietary complex of amino acids, vitamins, and antioxidants injected into the superficial dermis to intensively regenerate and rehydrate skin. Unlike pure HA skin boosters, Jalupro's amino acid matrix (glycine, proline, hydroxyproline, lysine) provides direct building blocks for collagen synthesis, making it more than a simple moisturising treatment. Indicated for the face, neck, décolletage, and hands, the treatment visibly brightens and firms skin from the first session, with cumulative improvement across a three-to-four-session course. Particularly effective for sun-damaged, dehydrated, or post-acne skin.