Mesotherapy in Czechia

Bioremodeling injections at RAJSKA Clinic — using Profhilo, Structura, or RRS HA LOLA — deliver the highest available concentration of stabilised hyaluronic acid directly into the skin, providing intense hydration combined with a biostimulatory signal to tighten and remodel collagen and elastin. Unlike standard fillers, bioremodeling products spread through the tissue from a small number of bio-aesthetic injection points, treating a large area with minimal needle insertions. The result is a marked improvement in skin quality, firmness, and radiance across the face, neck, décolletage, arms, or above-knee area after just two sessions.

Profhilo is a high-concentration, stabilised hyaluronic acid bioremodelling injectable that diffuses through the dermis to improve skin laxity, hydration, and elasticity. Delivered via the BAP technique at five anatomical points per side of the face, it stimulates collagen and elastin production without adding visible volume.

Skin boosters and bio-revitalisation improve skin quality from within — hydration, firmness, elasticity and glow — using injectable hyaluronic-acid and regenerative products rather than volume fillers. BB Health Clinic offers Profhilo (a slow-release stabilised hyaluronic acid that hydrates and bio-remodels), Jalupro and classic vitamin mesotherapy, PRP platelet-rich plasma made from your own blood, and Rejuran polynucleotide treatments for the face, scars and delicate eye area. Performed by a physician, these suit adults with tired, dehydrated or early-ageing skin wanting a natural improvement in skin condition.

Skin boosters and bioremodelling at TobePrime Clinic are injectable skin-quality treatments rather than volume fillers: micro-deposits of non-cross-linked or lightly structured hyaluronic acid hydrate the skin from within, while bioremodelling formulations additionally trigger the skin's own collagen and elastin production. The result is firmer, deeply hydrated, more elastic skin with a visible glow — without changing facial shape. Both options are priced at 7,500 Kč per session.

Profhilo bioremodeling injection (2 ml) — a hybrid HA injectable that simultaneously hydrates deeply and stimulates collagen and elastin production across all four skin layers, restoring skin quality and firmness without adding volume or changing facial shape.

Profhilo bioremodeling injection (2 ml) — high-concentration, thermally stabilised HA that hydrates deeply and biostimulates collagen and elastin across all skin layers without adding volume.

Polynucleotide (PDRN) injections at FaceExpert use salmon-derived DNA fragments to activate natural skin cell regeneration — stimulating collagen and elastin production, improving tissue hydration, and evening skin tone without adding volume. PDRN acts on A2A adenosine receptors on skin fibroblasts and keratinocytes, triggering cell proliferation and tissue remodelling pathways backed by peer-reviewed clinical evidence. At FaceExpert, the treatment is applied to two primary areas: the eye contour (targeting the delicate under-eye skin for dark circle improvement and periorbital crepiness reduction) and atrophic scar treatment (particularly boxcar and rolling acne scars). Single sessions are available at 7,900 Kč, with 2- and 3-session packages offering meaningful savings. Results are progressive, appearing over 4–8 weeks per session as new collagen matures. Polynucleotide biostimulation is increasingly preferred over traditional mesotherapy by patients who want deeper skin regeneration without volumisation or the foreign-body response of synthetic fillers.

Biorevitalization at Altos Klinika delivers non-cross-linked hyaluronic acid into the skin through a grid of micro-injections, deeply hydrating the dermis and stimulating its own regeneration. Treatments start at 7,900 Kč depending on area and product volume, with a more intensive dermarevitalization protocol available from 14,900 Kč.

Profhilo at Esthé Laser Clinic is an injectable skin remodelling treatment using one of the highest concentrations of pure, stabilised hyaluronic acid available — 64 mg in 2 ml, formulated without BDDE cross-linking agents. Unlike conventional dermal fillers that add volume in targeted zones, Profhilo spreads bio-revitalising hyaluronic acid across a wide skin area via a patented NAHYCO Hybrid Technology matrix. It stimulates four types of collagen and elastin simultaneously, producing a deep moisturisation and firmness effect that transforms skin quality from within rather than augmenting or reshaping it. The protocol uses five precisely mapped injection points per side of the face (the BAP technique), minimising discomfort while maximising diffusion. Two sessions four weeks apart constitute the primary course; results are visible from the second week and continue improving for up to three months. Ideal for anyone noticing a loss of skin elasticity, laxity on the jawline or neck, or general dullness.

Rejuran is a skin-rejuvenation treatment using polynucleotides — natural DNA chains derived from salmon — injected into the skin to support the renewal of skin cells, improve elasticity and firmness and stimulate collagen and elastin. At Dermaestet it is offered for the face under numbing cream and is one of the current trends in aesthetic medicine, aimed at brightening, regenerating and smoothing fine lines and uneven texture. Results build progressively, so it is usually given as a course for the most visible improvement.

Spanish Glow is the clinic's premium single-session mesotherapy protocol combining two high-concentration RRS products — RRS Long Lasting and RRS Hyalift — for intensive skin hydration, luminosity and visible plumping in a single appointment. Unlike the standard mesotherapy course, Spanish Glow is optimised for impact from the first session, making it popular before significant events or as a high-intensity maintenance treatment. Priced from 8 400 Kč, it delivers noticeably improved glow, suppleness and hydration that lasts 4–6 weeks.

Profhilo is a 97% hyaluronic acid bioremodeling injectable at Follow Clinic that stimulates elastin and collagen production throughout the skin, improving overall skin quality rather than targeting specific lines or adding volume. Two sessions administered 4 weeks apart are recommended at a combined cost of 15,000 Kč. Each 2 ml syringe contains 64 mg of HA and spreads up to 2 cm from each of the 5 BAP injection points, making it one of the most efficient skin boosters available. Results last 6–12 months and can be applied to the face, neck, chest, arms, hands, or knees.

Profhilo is the original skin 'bioremodelling' injectable — one of the highest concentrations of pure, non-crosslinked hyaluronic acid on the market (64 mg in 2 ml). Injected at five standardised points per side of the face, it spreads through the tissue like honey rather than sitting as volume, intensely hydrating the skin and stimulating four types of collagen and elastin. The result over the standard two-session protocol is firmer, denser, glowing skin and a subtle tightening of early laxity — without changing face shape. AMEM also offers Profhilo Structura, a cannula-applied version that restores the superficial fat layer for cheek and lower-face support ('lipolifting'). Package pricing covers the full two-treatment protocol.

Profhilo is a pure stabilised hyaluronic-acid injectable that works as a bio-remodeler rather than a volumising filler: instead of adding volume at specific points, it spreads within the tissue after injection, attracting and binding water across a broad zone while stimulating the skin's own collagen and elastin production. The result is improved skin hydration, tone, texture and elasticity — a general quality uplift rather than targeted volume correction. At Derma Medical Clinic, Profhilo is used for dehydrated, tired, lax or textured skin of the face, neck and décolletage.

Profhilo Structura is a newer bio-remodelling formulation designed specifically to act on the deep fat compartments of the face. Using a high concentration of ultra-pure hyaluronic acid, it strengthens these subcutaneous fat pads to restore the support that is lost with age, addressing hollow cheeks, loss of mid-face volume and a generally tired or drawn expression. At Dermaestet it is offered as a natural-looking way to regain facial firmness and contour without conventional volumising filler, with results that develop progressively.

Autologous plasma therapy at BODY klinika that combines the patient's own platelet-rich plasma — drawn from a blood sample taken on the day — with hyaluronic acid for enhanced skin hydration and regeneration. Growth factors and proteins in the concentrated plasma stimulate collagen production, firm the skin, and improve tone and brightness over the four to six weeks following each session. The procedure takes approximately 20–30 minutes and uses no synthetic or foreign materials, making it suitable for sensitive skin. Fixed price: 9,500 Kč per session.

Polynucleotide (PN) skin regeneration at AMEM Zlín — headlined by Rejuran, the Korean salmon-DNA injectable that repairs skin at the cellular level rather than filling it. Purified DNA fragments stimulate fibroblast activity, dermal repair and elasticity, improving texture, fine lines, enlarged pores and post-acne skin quality over a course of treatments. The physician applies Rejuran across the full face (9,880 Kč, three-course package 23,985 Kč) or with an atraumatic needle for delicate zones. More affordable injector-applied skin boosters combining salmon DNA polynucleotides with hyaluronic acid — applied by the clinic's trained nurses — extend the menu to face, neck and décolleté from 6,900 Kč.

PRP Plasmalifting at Petra Clinic uses the patient's own platelet-rich plasma to rejuvenate the skin through natural growth-factor stimulation. A small blood sample is drawn, centrifuged in the clinic's REGEN preparation system to concentrate platelets to three to five times physiological levels, then applied via multiple microinjections into the dermis of the face, neck or scalp. Platelets release a cocktail of growth factors — PDGF, TGF-β, VEGF, EGF — that activate resident fibroblasts, stimulate collagen and elastin synthesis, and improve tissue hydration. Because the treatment uses the patient's own biological material, the risk of allergic reaction is essentially zero. Two days without makeup is the typical post-treatment precaution; effects last up to twelve months.

Mesotherapy at Petra Clinic delivers a customised cocktail of active substances — vitamins, minerals, amino acids, hyaluronic acid, antioxidants and optionally the patient's own plasma — directly into the mid-dermis through multiple fine microinjections. By bypassing the skin barrier, mesotherapy concentrates bioactive molecules at the site where fibroblasts, keratinocytes and microvascular endothelium are actively metabolising, producing improvements in hydration, skin quality, brightness and fine-line reduction that topical application cannot replicate. The specific cocktail is tailored by the physician to the individual's skin condition, age and goals. A course of two to three sessions per year maintains and advances the benefit.

Polynucleotide (PDRN/PN) biostimulation injections at SKIN CARE Liberec deliver a highly purified preparation of long-chain DNA fragments — derived from salmon sperm or medical-grade plant sources — into the dermis to trigger deep cellular regeneration, improve skin hydration, and stimulate collagen and elastin synthesis through a receptor-mediated pathway. Unlike growth factor mesotherapy which delivers signalling proteins, polynucleotides work by activating the purinergic receptor (A2A) on fibroblasts, which upregulates the entire cellular repair programme — collagen synthesis, antioxidant defence, and ECM restoration — from within the cell. The treatment requires three sessions at monthly intervals for full effect. Pricing from 10,000 Kč for whole face; a three-session under-eye package is available at 15,000 Kč.

Salmon DNA Skin Rejuvenation at Petra Clinic uses Rejuran polynucleotide (PDRN) microinjections to activate the skin's repair machinery from within. PDRN — purified from salmon milt DNA — binds to adenosine receptors on fibroblasts, switching on collagen and elastin synthesis while simultaneously exerting anti-inflammatory effects that calm sensitised skin. Unlike hyaluronic acid fillers that add volume passively, PDRN triggers the skin's own regenerative pathways. The treatment is delivered as a series of precise microinjections into the mid-dermis of the face; results are visible after the first session and improve progressively. Minimal downtime — two days without makeup — and no allergy risk from salmon DNA (highly purified to remove proteins) make this a popular preventive and corrective treatment.

The Vital Injector System skinbooster is a controlled micro-injection treatment that delivers pure non-cross-linked hyaluronic acid deep into the dermis of the face, neck, décolleté, or hands. At Kožní Keclíková, the Vital Injector device — part of the Restylane product family — uses a multi-needle stamping mechanism to deposit precise quantities of HA at a consistent depth and spacing, achieving a more uniform result than manual mesotherapy injections. The HA binds water molecules within the dermal tissue, producing lasting deep hydration, stimulating collagen and elastin synthesis, brightening, and progressive skin firming. Visible improvements in skin texture and radiance typically develop after the first session and deepen with subsequent treatments.

Hair mesotherapy at RVmedCentrum delivers a targeted cocktail of polynucleotides, hyaluronic acid, biomimetic peptides, growth factors, and vitamins directly into the scalp via ultra-thin needles or an applicator pen. The combination of active ingredients nourishes hair follicles, halts excessive hair loss, and promotes active regrowth. It is the clinic's specialist non-surgical treatment for hair thinning, brittleness, and seborrheic dermatitis, offered as an initial course of 4 sessions.

Desirial intimate area rejuvenation at S-thetics Beauty uses hyaluronic acid formulations specifically designed for the vulvovaginal region — Desirial® for hydration and rejuvenation, and Desirial® Plus for volume restoration and shape correction. Both products are part of the Vivacy/IBSA product family, the same manufacturer as the Stylage filler range used for facial treatments. MDDr. Darina Šanšašvili administers the injections in the clinic setting. The treatment addresses dryness, loss of elasticity, reduced volume, and aesthetic changes in the intimate area — conditions that commonly arise from hormonal changes after menopause, post-partum recovery, or the natural ageing process. Results include improved hydration, increased tissue suppleness and elasticity, enhanced intimate comfort, and aesthetic improvement of the vulvovaginal area. The effect of a single 2 ml session typically lasts six to twelve months.