Profhilo Skin Remodelling

Profhilo at Esthé Laser Clinic is an injectable skin remodelling treatment using one of the highest concentrations of pure, stabilised hyaluronic acid available — 64 mg in 2 ml, formulated without BDDE cross-linking agents. Unlike conventional dermal fillers that add volume in targeted zones, Profhilo spreads bio-revitalising hyaluronic acid across a wide skin area via a patented NAHYCO Hybrid Technology matrix. It stimulates four types of collagen and elastin simultaneously, producing a deep moisturisation and firmness effect that transforms skin quality from within rather than augmenting or reshaping it. The protocol uses five precisely mapped injection points per side of the face (the BAP technique), minimising discomfort while maximising diffusion. Two sessions four weeks apart constitute the primary course; results are visible from the second week and continue improving for up to three months. Ideal for anyone noticing a loss of skin elasticity, laxity on the jawline or neck, or general dullness.

Profhilo belongs to the category of bioremodellers — a distinct class of injectable product from both traditional hyaluronic acid fillers and mesotherapy cocktails. Its defining characteristic is its concentration: 64 mg of hyaluronic acid in a 2 ml syringe, approximately double the HA concentration found in standard tissue fillers, yet without the BDDE (1,4-butanediol diglycidyl ether) cross-linking that makes conventional fillers volumetric and localised. Instead, Profhilo uses NAHYCO Hybrid Technology, a thermal stabilisation process that creates a hybrid cooperative complex of high-molecular-weight and low-molecular-weight HA chains that diffuse rapidly and broadly through the tissue. At Esthé Laser Clinic in Prague's Na Příkopě, Profhilo is administered by qualified medical practitioners using the BAP (Bio Aesthetic Points) technique: five injection points per side of the face, positioned at anatomically defined coordinates that allow the product to spread into multiple tissue planes without pooling. The points cover the cheek body, pre-jowl zone, chin, and midface. Each injection delivers the product precisely into the superficial fat compartments where it can spread centrifugally over the following hours and days. Once in the tissue, the HA matrix acts as a scaffold that simultaneously stimulates fibroblasts to produce type I and type III collagen and elastin. The high-MW component of the hybrid provides the structural scaffold; the low-MW component drives the immediate bio-stimulating activity. The net effect, which becomes measurable at 4–6 weeks post-treatment, is a visible firming of the skin across the whole treated area — not a volumetric change, but an improvement in turgor, elasticity, and overall skin quality. The skin surface appears more hydrated, textured, and reflective because the dermis below it has regained structural density. The standard Profhilo course at Esthé is two sessions four weeks apart. The first session initiates the remodelling cascade; the second reinforces and amplifies it. Clinical studies report that both collagen and elastin production peak at around 4 weeks after the second session, meaning the most significant visible improvements arrive between weeks 6 and 12 of the course. A maintenance session every 6–12 months thereafter preserves the structural improvements. The treatment is well-tolerated. Side effects are typically limited to small injection-site papules (the product's spread creates a visible bleb that absorbs over 30–60 minutes), occasional mild bruising, and temporary skin sensitivity. Because Profhilo contains no cross-linking agents, the risk of granuloma formation or product migration is minimal compared with conventional dermal fillers. Preparation: avoid blood-thinning medications and supplements (aspirin, ibuprofen, omega-3 fatty acids, vitamin E) for 10 days before the appointment to minimise bruising risk. No dental procedures within 2 weeks (infection risk). Arrive with clean, makeup-free skin. Ideal candidates: patients aged 30+ experiencing gradual loss of skin tone and elasticity without wanting volumetric changes; patients with laxity along the jawline, neck, or décolletage; patients seeking a natural-looking improvement in skin quality rather than obvious augmentation. Contraindications: known allergy to hyaluronic acid products, active skin infection or inflammation in the treatment area, pregnancy or breastfeeding, autoimmune connective tissue diseases, current anticoagulant therapy.