Profhilo — Skin Bioremodeling (2 ml)

Profhilo bioremodeling injection (2 ml) — a hybrid HA injectable that simultaneously hydrates deeply and stimulates collagen and elastin production across all four skin layers, restoring skin quality and firmness without adding volume or changing facial shape.

Profhilo is categorically distinct from conventional dermal fillers and mesotherapy. Its uniquely high HA concentration (64 mg per 2 ml syringe) and thermal stabilisation process without BDDE cross-linking allows it to flow freely through tissues and biostimulate fibroblasts across a wide zone from just five injection points per side of the face (the BAP — Bio Aesthetic Points — protocol). Unlike fillers that add volume to a discrete location, or mesotherapy that delivers micronutrient cocktails to the dermis, Profhilo works by releasing both high-molecular-weight HA (for deep tissue hydration and scaffold support) and low-molecular-weight HA (for fibroblast activation and anti-inflammatory signalling) simultaneously. At Premier Clinic, a 2 ml Profhilo session is priced at 7,900 CZK (approximately 316 EUR). The standard protocol involves two sessions spaced four weeks apart, totalling 15,800 CZK (approximately 632 EUR) for the complete primary course — compared to 600 to 900 EUR for the same two-session protocol in Germany or the UK. A maintenance session every six months sustains the results. The five-point BAP injection technique places Profhilo at anatomically optimal points that avoid vascular structures while ensuring maximum radial distribution of the HA through the subcutaneous tissue. Because no cross-linking agents are used, the product integrates naturally with existing tissue and leaves no lumps, swelling, or risk of Tyndall effect. The only expected side effects are small wheals at the injection points that flatten within 24 hours. Patients typically notice initial hydration improvement within one week and progressive skin quality improvement — increased firmness, elasticity, and skin texture — over the four to eight weeks following each session as new collagen and elastin are laid down. Profhilo is equally effective for the face, neck, décolleté, hands, and arms.