10 Best Mesotherapy Clinics in Prague (2026)
We ranked the top 10 of 32 mesotherapy clinics in Prague by patient reviews, pricing, and international patient services. Prices from Kč 1,500 to Kč 6,000.
Clinics
32
Avg Rating
4.9/5
From
Kč 1,500
Top Rated
Artmedica Clinic
Best Value
FaceExpert
Mesotherapy Clinics
Artmedica Clinic
Žatecká 55/14, Staré Město (Josefov), Praha 1, 110 00, Czech Republic
Artmedica Clinic is a private aesthetic medicine practice in the heart of Prague's Staré Město (Old Town), founded and led by MUDr. Kateřina Adamcová — an ENT surgeon from Charles University's 3rd Medical Faculty who holds international certification in aesthetic and anti-aging medicine and is one of only three APTOS thread-lift trainers in the entire Czech Republic. The clinic operates the Alma Harmony multi-platform laser system (ClearLift, ClearSkin, Dye-VL and Bio-Boost modules) and the Candela GentleLASE alexandrite laser with dual dynamic cooling, covering permanent hair removal, skin rejuvenation, pigmentation and vascular lesion treatment. Injectable services include Allergan botulinum toxin for wrinkles and hyperhidrosis, premium hyaluronic-acid fillers, Profhilo bioremodeling, polynucleotide biostimulation (PDRN), Xela Rederm Swiss redermalization — which Artmedica introduced to Czech Republic as the first clinic — and PRP plasma therapy. Body contouring is handled with LESC cold-ultrasonic liposuction under local anaesthesia only, and injectable lipolysis. The multidisciplinary team includes MUDr. Alena Stumpfová (board-certified dermatovenerologist), head nurse Marcela Štěpánková (50+ years' specialist experience in laser hair removal and Dermapen), and nurse Petra Pavlíková with ICU and cosmetology background. The clinic holds accreditation from the Czech Medical Chamber, IMCAS Academy, AMWC and the Allergan Medical Institute. On Reservio the clinic carries a perfect 5.0 / 5.0 score across 75 verified reviews.
Available Mesotherapy:
PDRN (polydeoxyribonucleotide) biostimulation uses concentrated DNA fragments extracted from wild salmon and injected via fine needle into the face, neck, décolletage or hands. The DNA extract is biocompatible with human tissue and works by binding to adenosine receptors on skin cells, stimulating fibroblast proliferation and collagen synthesis. Results include visible lifting, tightening, improved skin elasticity, pore minimisation and reduction in dark circles — with improvement from the first session and progressive gains over a course of two to four treatments.
Xela Rederm is a Swiss-developed injectable skin booster combining hyaluronic acid with amber acid (sodium succinate) — a Krebs cycle metabolite that stimulates fibroblasts to produce collagen and elastin independent of any external laser or RF energy. The injected formula simultaneously provides deep hydration (from the HA component) and active cellular regeneration (from the succinate component), producing visibly smoother, firmer and more radiant skin within three days. Artmedica Clinic Prague was the first clinic in the Czech Republic to offer Xela Rederm, positioning it as an early adopter of this Swiss aesthetic innovation.
Skin revitalisation mesotherapy delivering customised cocktails of hyaluronic acid, vitamins, minerals, antioxidants and nucleic acids by microinjection directly into the mesodermal skin layer. At Artmedica Clinic Prague a single-point cannula or a 9-needle injector delivers the formula in a structured pattern across face, neck, eye area, décolletage or hands. The intradermal delivery bypasses the skin barrier entirely, achieving concentrations of active ingredients that topical products cannot reach. Results include improved elasticity, hydration, skin appearance and collagen stimulation with minimal downtime.
Profhilo bioremodeling delivers a unique combination of high and low molecular weight hyaluronic acid via just ten injection points using the BAP (Bio Aesthetic Points) technique. Unlike standard dermal fillers it does not add volume or structure — it stimulates the skin's own production of collagen, elastin and HA for firmer, more elastic and visibly hydrated skin. The two-session protocol (one month apart) produces gradual improvement in skin quality that continues to develop for weeks after the final session. Artmedica Clinic Prague offers both standard Profhilo and the Profhilo Structura variant for deeper tissue remodelling.
Intravenous vitamin infusion therapy delivering high-dose vitamin C, B-complex vitamins, magnesium, calcium, glutathione and citicoline directly into the bloodstream for immediate absorption — bypassing the digestive system entirely. Three curated protocols target different goals: Vitality, Immunity and Energy for chronic fatigue and frequent infections; Prevention First with glutathione for antioxidant and detox support; and Stress Killer with glutathione and citicoline for cognitive performance and nerve cell protection. Available at Artmedica Clinic Prague with medical oversight.
Eternal Clinic
Chlumčanského 497/5, 180 00 Praha 8 - Libeň (Bulovka Business & Medical Centre)
Eternal Clinic is a premium aesthetic medicine center in Prague led by two experienced surgeons from Motol University Hospital - MUDr. Patrik Palenčár and MUDr. Alena Mušálková. They combine years of surgical expertise with modern aesthetic procedures for natural, long-lasting results. Services include comprehensive hair loss treatment, hair transplantation, skin rejuvenation, botulinum toxin, dermal fillers, and blepharoplasty. Installment payment plans available.
Available Mesotherapy:
Follow Clinic
Sinkulova 38/2, 147 00 Praha 4-Podolí, Czech Republic
Follow Clinic is an aesthetic medicine and cosmetic clinic located at Sinkulova 38/2 in the upscale Prague 4-Podolí neighbourhood, steps from the Vltava riverbank. The clinic was founded on a philosophy of individualized care and natural results — a direct response to the founders' own negative experiences at impersonal aesthetic clinics. Every treatment plan is tailored to the individual client rather than applying a one-size approach. The medical team includes dermatologist MUDr. Nikola Lochmanová, Dr. Nicole Kufelová (aesthetic medicine, lip filler specialist), Dr. Hana Brázdová (anti-aging medicine and certified Karisma biostimulant trainer for the Italian brand), Dr. Anna Zborovská (botulinum toxin), and founder Ivona Jarolímová (plasma pen specialist). Injectable treatments use premium products including Stylage (French HA with antioxidants), Juvéderm, Profhilo (97% HA bioremodeling), Radiesse, and Aptos threads. Cosmetic facial treatments are delivered with Dermapen for microneedling combined with Hyalual chemical peels, biorevitalization, exosomes, and the premium Nanoderm and DUBAJ Blue Elixir protocols. Luxury MEDISPA facials are offered using Orveda — a globally recognized pure vegan skincare brand. The clinic is open Monday–Friday 09:00–18:00 by appointment, with online booking via the Alteg platform. Reviews on Firmy.cz rate the clinic 100 out of 100, with clients highlighting the warm, attentive care and high-quality results from treatments such as dermapen.
Available Mesotherapy:
Mesotherapy for the under-eye area at Follow Clinic delivers low-molecular-weight hyaluronic acid directly into the delicate skin below the eye via micro-injections, improving hydration, skin thickness, and the appearance of dark circles caused by thin or dehydrated skin (rather than structural hollowing). At 4,900 Kč per session, it is a gentle, non-volumizing alternative to tear trough filler — ideal for clients with fine-textured periorbital skin. A series of 2–4 sessions spaced 2–4 weeks apart is recommended for cumulative benefit, with maintenance every 4–6 months thereafter.
Injectable lipolysis at Follow Clinic uses a phosphatidylcholine/deoxycholate compound injected directly into subcutaneous fat deposits to permanently destroy and dissolve localized fat cells. Targeted areas include the submental chin (from 3,500 Kč per session), abdomen and flanks (from 5,500 Kč), and inner thighs (from 7,200 Kč). Multi-session packages offer significant savings: up to 3 sessions for the abdomen at 15,000 Kč. Two to three sessions are typically needed for optimal contouring results. Swelling and redness in the treated area are expected for 1–2 weeks. Performed by a doctor.
Profhilo is a 97% hyaluronic acid bioremodeling injectable at Follow Clinic that stimulates elastin and collagen production throughout the skin, improving overall skin quality rather than targeting specific lines or adding volume. Two sessions administered 4 weeks apart are recommended at a combined cost of 15,000 Kč. Each 2 ml syringe contains 64 mg of HA and spreads up to 2 cm from each of the 5 BAP injection points, making it one of the most efficient skin boosters available. Results last 6–12 months and can be applied to the face, neck, chest, arms, hands, or knees.
RAJSKA Clinic
Lighthouse Building B, Jankovcova 1566/2B, Praha 7 – Holešovice, 170 00, Czech Republic
RAJSKA Clinic is a private aesthetic dermatology practice located in Lighthouse Building B in Praha 7 – Holešovice, founded and led by MUDr. Lucie Rajská, Ph.D., who holds a medical degree from Masaryk University (2010) and a doctorate from Charles University's 2nd Faculty of Medicine (2017), with prior clinical experience at Na Bulovce Hospital and specialised certifications in anti-aging medicine. The clinic operates without any health insurance contracts — every treatment is private — which allows it to maintain appointment depth and individualised care over throughput. Seven physicians cover the full spectrum from general and paediatric dermatology to advanced injectable aesthetics and surgical mole removal, making RAJSKA unusual among aesthetic practices in being able to handle clinical skin conditions alongside cosmetic procedures in a single visit. Equipment highlights include the VIVACE microneedle radiofrequency system for deep collagen and elastin remodelling, the ALMA PIXEL CO2 fractional laser for both superficial rejuvenation and deep resurfacing, and the ADENA LCD G+ IPL platform for vascular and pigmentation concerns. Injectable offerings span botulinum toxin (Bocouture, Baby Botox, full-face protocol), hyaluronic acid fillers, Radiesse calcium hydroxyapatite lifting, Profhilo and Structura bioremodelling, Jalupro biorevitalisation, and Aptos thread lifting with multiple thread types. The clinic openly claims a 5/5 Google rating with 14-plus named testimonials displayed on the homepage, praising the team's precision, warmth, and commitment to natural outcomes. Appointments typically require at least two weeks' advance booking, and the clinic's philosophy — "aesthetics without exaggeration, naturalness without compromise" — is reinforced through its choice not to accept walk-ins or insurance-driven time pressures.
Available Mesotherapy:
Jalupro Super Hydro biorevitalization at RAJSKA Clinic combines hyaluronic acid with a proprietary complex of amino acids, vitamins, and antioxidants injected into the superficial dermis to intensively regenerate and rehydrate skin. Unlike pure HA skin boosters, Jalupro's amino acid matrix (glycine, proline, hydroxyproline, lysine) provides direct building blocks for collagen synthesis, making it more than a simple moisturising treatment. Indicated for the face, neck, décolletage, and hands, the treatment visibly brightens and firms skin from the first session, with cumulative improvement across a three-to-four-session course. Particularly effective for sun-damaged, dehydrated, or post-acne skin.
Bioremodeling injections at RAJSKA Clinic — using Profhilo, Structura, or RRS HA LOLA — deliver the highest available concentration of stabilised hyaluronic acid directly into the skin, providing intense hydration combined with a biostimulatory signal to tighten and remodel collagen and elastin. Unlike standard fillers, bioremodeling products spread through the tissue from a small number of bio-aesthetic injection points, treating a large area with minimal needle insertions. The result is a marked improvement in skin quality, firmness, and radiance across the face, neck, décolletage, arms, or above-knee area after just two sessions.
Mesotherapy at RAJSKA Clinic uses biocompatible injectable blends — Neauvia Organic Hydrodeluxe for facial skin, and scalp-specific formulations and hair polynucleotides for hair loss — to deliver active ingredients directly into the target tissue layer. Neauvia Organic uses high-purity HA from non-animal bacterial fermentation, enriched with hydroxyapatite and glycine for enhanced biocompatibility. Scalp mesotherapy and hair polynucleotides address androgenic alopecia, telogen effluvium, and stress-related hair loss with a nutrient-rich injection protocol that extends the anagen (growth) phase of the hair cycle. A course of at least three sessions is standard.
Be Elite Clinic
Jindřišská 20, 110 00 Praha 1, Czech Republic
Be Elite Clinic is a private aesthetic medicine and plastic surgery center in the heart of Prague led by MUDr. Monika Kavková, an internationally certified expert with APTOS certification. They combine classic Western medicine with unique Eastern methods for non-invasive lifting.
Available Mesotherapy:
FaceExpert
FaceExpert, Maiselova 19, 110 00 Praha 1 – Josefov, Czech Republic
FaceExpert (Klinika estetické medicíny Praha) is a boutique aesthetic medicine practice located at Maiselova 19 in Josefov, the historic Jewish Quarter of central Prague 1. The clinic was founded by MUDr. Zuzana Macko, an aesthetic dermatologist and internationally recognised trainer who is certified by TEOXANE, Merz Aesthetics, and the MINT thread lifting system. She sits on the boards of SELM, IMCAS Academy, CAM Aesthetics, AMWC Academy, AMS, and the Czech Academy of Dermatovenereology — an unusually broad set of accreditations for a single-founder clinic. The team includes MUDr. Kateřina Besperát for aesthetic medicine and laser treatments, and MUDr. Alexandra Reptišová who specialises in non-invasive rhinoplasty and holds an additional qualification from Turkey. The clinical space is finished in a French-inspired boutique interior with artwork and a luxury atmosphere that sets it apart from the majority of Prague's medical aesthetic providers. The service catalogue covers the full non-surgical facial rejuvenation spectrum: botulinum toxin across 14 distinct areas, hyaluronic acid fillers, PDO/PLLA thread lifting, Ultraformer III HIFU, Morpheus 8 RF microneedling, Lumecca IPL, HydraFacial with LightStim LED, medical microneedling, chemical peels, biostimulation with Radiesse and Sculptra, PRP plasma therapy, polynucleotide injections, and diode laser hair removal. The clinic maintains a 4.9/5 rating from 51 verified reviews on Estheticon.cz with a 98% recommendation rate, and also runs the Dr. Macko Academy for physician education and an in-house SkinCeuticals product e-shop.
Available Mesotherapy:
FaceExpert's Skincare Consultation uses the Observ diagnostic system — a professional multi-spectral illumination device that reveals skin characteristics invisible under standard lighting — to give patients and the physician a complete, evidence-based picture of their skin health before selecting any treatment. The Observ uses six different light modes (including UV fluorescence and cross-polarisation) to assess surface texture, pore size, pigmentation depth, sebum distribution, and the condition of deeper skin layers. The session at FaceExpert includes a physician-led consultation, the Observ diagnostic imaging assessment, personalised treatment recommendations matched to the patient's actual skin biology rather than visible surface appearance alone, and skincare product recommendations from the clinic's SkinCeuticals range. At 1,500 Kč, this consultation is an accessible entry point for new patients and is recommended before committing to more intensive treatments such as chemical peels, laser, or RF microneedling. The consultation price is credited against the first treatment booked at the same visit.
Polynucleotide (PDRN) injections at FaceExpert use salmon-derived DNA fragments to activate natural skin cell regeneration — stimulating collagen and elastin production, improving tissue hydration, and evening skin tone without adding volume. PDRN acts on A2A adenosine receptors on skin fibroblasts and keratinocytes, triggering cell proliferation and tissue remodelling pathways backed by peer-reviewed clinical evidence. At FaceExpert, the treatment is applied to two primary areas: the eye contour (targeting the delicate under-eye skin for dark circle improvement and periorbital crepiness reduction) and atrophic scar treatment (particularly boxcar and rolling acne scars). Single sessions are available at 7,900 Kč, with 2- and 3-session packages offering meaningful savings. Results are progressive, appearing over 4–8 weeks per session as new collagen matures. Polynucleotide biostimulation is increasingly preferred over traditional mesotherapy by patients who want deeper skin regeneration without volumisation or the foreign-body response of synthetic fillers.
PRP plasma therapy at FaceExpert uses the patient's own blood — drawn, centrifuged to isolate the platelet-rich plasma fraction, and re-injected into the target tissue — to deliver a concentrated payload of growth factors that stimulate collagen production, improve skin quality, and support tissue regeneration. The treatment is completely autologous: because it uses the patient's own plasma, the risk of allergy or immune reaction is essentially zero. FaceExpert performs PRP with either 1 vial (6,900 Kč) or 2 vials (10,900 Kč) of processed plasma depending on the treatment zone and concentration needed. The therapy is used for facial skin rejuvenation, acne scarring, hair loss on the scalp, and general skin quality enhancement. Growth factors from activated platelets — PDGF, TGF-β, VEGF, EGF — trigger fibroblast proliferation, collagen synthesis, and angiogenesis. Visible improvement in skin luminosity and texture appears over 4–8 weeks per session, with 2–3 sessions recommended for sustained results.
Estetické centrum Praha
Sportovní klub Oáza, Perlitová 1870/31, 1. poschodí vpravo, 140 00 Praha 4 — Krč / Zelená Liška
Estetické centrum Praha, operating under the brand e-botox.cz, is a private self-pay aesthetic medicine clinic on the first floor of the Hotel Oáza complex in Krč, Praha 4. The practice is owned and exclusively operated by MUDr. Renata Handlová, who trained at Charles University's Faculty of General Medicine and subsequently spent years as an ophthalmologist at the I. Eye Clinic and Královské Vinohrady Teaching Hospital before dedicating herself to aesthetic medicine from 1998, with full primary specialisation from 2010. Her ophthalmic background provides unusually precise anatomical knowledge of the periocular musculature — a direct advantage in botulotoxin placement around the eyes, forehead and glabella where millimetre precision determines outcome. She holds certificates from Allergan, Q-med, Neomed and Neostrata, and is a regular attendee of the AMWC Monaco, IMCAS Paris and EMAA international congresses, keeping the clinic's protocols current with European best practice. The treatment portfolio covers injectable aesthetics (botulinum toxin for wrinkles and hyperhidrosis, the full Restylane and Juvederm 3D-modelling filler ranges), skin resurfacing (MiXto SX fractional CO2 laser, AHA chemical peeling), body-contouring injectables (mesotherapy, injection lipolysis with phosphatidylcholine), and permanent laser hair removal with the Candela GentleLASE system featuring DCD skin-cooling. The clinic accepts appointments by phone only and operates on a self-pay basis with no health insurance contracts. Google reviews rate it 4.8 out of 5 across 70 reviews.
Swiss Esthetic
Kateřinská 1476/34, Praha 2 – Nové Město, 120 00, Czech Republic
Swiss Esthetic is a dedicated aesthetic medicine clinic in Prague providing a focused menu of non-surgical facial treatments delivered under medical supervision. The clinic takes its name from the Swiss approach to precision and understated results — every treatment plan prioritises natural-looking outcomes rather than an obviously treated appearance. The core competencies are botulotoxin wrinkle correction, PDO mono-thread lifting, and complementary skin-enhancement procedures including mesotherapy, chemical peels, microneedling, and laser skin rejuvenation. Patients come to Swiss Esthetic for fine-line smoothing, brow or jawline repositioning, skin hydration replenishment, and scar or pigmentation correction. All injectable procedures are performed by a qualified aesthetic doctor using CE-marked materials, and dosages are individualised at each appointment based on anatomical assessment. The clinic operates across Prague and also has a Brno presence, making it accessible to clients throughout the Czech Republic. Consultations are available in Czech and English. Online booking is available via the clinic website, and first-time patients receive a complimentary skin assessment before any treatment is agreed. The clinic has earned positive reviews from clients who highlight the natural-looking results, attentive aftercare communication, and fair transparent pricing.
EUDERMA - Dermatologie Prof. Hercogové
Chlumčanského 497/5, 180 00 Praha 8 - Libeň (Bulovka Medical & Business Centre, 3rd floor)
EUDERMA is the largest private center for biological treatment in Czech Republic, led by Prof. MUDr. Jana Třešňák Hercogová, president of the European Academy of Dermatology. The clinic treats 64,000+ patients annually with 20+ specialists. Services include clinical dermatology, biological therapy for psoriasis and eczema, lymphology, oncology, and aesthetic dermatology with CO2 laser and injectables.
Available Mesotherapy:
LaserPlastic
Platnéřská 89/11, 110 00 Praha 1 - Staré Město, Czech Republic
LaserPlastic is a private clinic with over 22 years of tradition in aesthetic dermatology and plastic surgery. Led by experienced surgeons Miroslav Krejča PhD and Pavel Hlava, CSc., and dermatology chief MUDr. Marta Moidlová, they offer comprehensive aesthetic services including laser treatments, botox, fillers, and plastic surgery procedures.
Available Mesotherapy:
How We Ranked These Clinics
Rankings are based on patient reviews, pricing transparency, and service quality for mesotherapy in Prague:
- ✓ Patient Reviews – Aggregated from Google and verified review platforms
- ✓ Pricing Transparency – Clear, upfront pricing published online
- ✓ International Services – English-speaking staff, patient coordinators
- ✓ Range of Services – Variety of mesotherapy options available
Data Sources
- Longevity.haus Database: Clinic listings with direct partnerships (Updated: 2026-06-04)
- Google Reviews: Aggregated ratings from Google Maps – Ratings may vary over time
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