Type
Mesotherapy
Duration
25 min
What's included
3 deliverables in this treatment
- Physician assessment and injection mapping
- Rejuran PDRN microinjection session across agreed zones
- Post-injection cooling, aftercare serum and 48-hour care protocol
Salmon DNA Skin Rejuvenation at Petra Clinic uses Rejuran polynucleotide (PDRN) microinjections to activate the skin's repair machinery from within. PDRN — purified from salmon milt DNA — binds to adenosine receptors on fibroblasts, switching on collagen and elastin synthesis while simultaneously exerting anti-inflammatory effects that calm sensitised skin. Unlike hyaluronic acid fillers that add volume passively, PDRN triggers the skin's own regenerative pathways. The treatment is delivered as a series of precise microinjections into the mid-dermis of the face; results are visible after the first session and improve progressively. Minimal downtime — two days without makeup — and no allergy risk from salmon DNA (highly purified to remove proteins) make this a popular preventive and corrective treatment.
About this treatment
Rejuran at Petra Clinic contains polydeoxyribonucleotide (PDRN) — low-molecular-weight polynucleotide chains derived from salmon (Oncorhynchus mykiss) sperm DNA. Salmon DNA shares approximately 96% structural homology with human DNA and, after extensive enzymatic hydrolysis and purification to remove all proteins, poses no immunogenic risk. In the tissue PDRN acts primarily by binding to P1 (adenosine A2A) receptors on fibroblasts and endothelial cells,…
Good to know
- Active ingredient
- PDRN polynucleotides (salmon DNA)
- Mechanism
- Adenosine receptor activation → collagen + elastin synthesis
- Allergy risk
- Essentially zero — protein-free
- Downtime
- ~48 hours, minor papules for 4 hours
- Course
- 3 sessions, 4 weeks apart
Who is this for?
Skin quality improvement, fine lines, elasticity loss, sensitive or rosacea-prone skin
Preparation required
Arrive with clean skin. Optional topical anaesthetic applied at the clinic. Avoid active skincare for 48 hours after.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
84 clinic reviews
From independent platforms
Clinical team
Petra Clinic was founded and is managed by Mgr. Petra Řehořková, MBA, LL.M. The chief physician for corrective dermatology is MUDr. Theodora-Eleni Asimiadou, who oversees skin-health procedures and medical oversight of laser treatments. MUDr. Klaudia Hálová Karoliová holds specialisations in diabetology, endocrinology and obesity medicine, supporting clients with weight-related treatment plans and metabolic context.…
Languages: Czech, English
What clients say
"{"author":"Verified client (Firmy.cz)","text":"I've been visiting this clinic for a second year now and am very satisfied with the friendly staff and their approach. I also used the dermatology department to remove a skin growth.","source":"Firmy.cz","rating":5}"
"{"author":"Verified client (petraclinic.cz)","text":"Excellent results and a very professional team. I was nervous before my first laser treatment but the staff explained everything clearly and the whole process was comfortable.","source":"petraclinic.cz","rating":5}"
Treatment highlights
- Physician assessment and injection mapping
- Rejuran PDRN microinjection session across agreed zones
+1 more item in What's included
11,000 Kč per session. Results visible after first treatment; full effect develops over several weeks. Single session; course of 3 sessions typically recommended.