Facial Mesotherapy

Facial mesotherapy at DiVine Clinic delivers a concentrated blend of hydrating and rejuvenating substances — including hyaluronic acid, vitamins, minerals, and amino acids — directly into the skin via fine micro-injections administered by MUDr. Petra Moravcová. Unlike topical skincare that must penetrate the skin barrier from outside, mesotherapy bypasses the stratum corneum entirely, placing active ingredients precisely in the dermis where they can immediately influence fibroblast activity, skin hydration, and overall skin quality. The injection forms small papules that are barely visible and absorb within 1–2 days, leaving behind improved radiance, elasticity, and suppleness. The eye area treatment is specifically formulated for the delicate periorbital skin, addressing dark circles, fine lines, and under-eye crepiness. Polynucleotides (PDRN) are available as an option within the mesotherapy menu for patients who want a biostimulatory upgrade.

Mesotherapy is a technique originally developed by Dr Michel Pistor in France in 1952 for pain management, subsequently adapted for aesthetic medicine. The principle is consistent across applications: active substances are delivered via micro-injections into the mesoderm (the middle layer — in skin terms, the dermis and hypodermis), bypassing the transdermal barrier that limits the penetration of topically applied products. In aesthetic medicine, facial mesotherapy uses this precision delivery approach to introduce cocktails of active ingredients directly to the dermis, where they exert their effects on fibroblasts, keratinocytes, and the extracellular matrix. **Active ingredients in DiVine Clinic's mesotherapy cocktails:** *Hyaluronic acid (key component):* - Non-cross-linked HA at varying molecular weights is the foundation of most aesthetic mesotherapy protocols. Low-molecular-weight HA penetrates cell membranes and acts intracellularly; high-molecular-weight HA stays in the extracellular matrix where it attracts water via osmosis. The combination maintains both cellular and matrix hydration. *Vitamins and co-factors:* - Vitamin C (ascorbic acid): stimulates collagen type I synthesis; brightens pigmentation; antioxidant protection - Vitamin B complex: B5 (pantothenic acid) for skin barrier repair; B6 and B12 for keratinocyte function - Vitamin E: lipid-soluble antioxidant that stabilises cell membranes *Amino acids:* Building blocks for collagen and elastin synthesis — proline, glycine, lysine, and arginine are commonly included *Minerals:* Zinc (anti-inflammatory and wound-healing), copper (collagen cross-linking), silicon (structural protein support) *Polynucleotides (PDRN) — optional upgrade:* DiVine Clinic includes polynucleotides in the mesotherapy menu as a biostimulatory option. When PDRN is added to the mesotherapy cocktail or administered as a standalone mesotherapy session, the A2A receptor agonism adds a fibroblast proliferation signal beyond what vitamins and HA alone provide. **Injection technique:** MUDr. Moravcová uses a technique of micro-papule injections across the treatment zone — each injection deposits a tiny aliquot of the mesotherapy cocktail just below the epidermis. The resulting micro-papules are visible immediately but flatten as the product disperses through the tissue within 24–48 hours. There is minimal discomfort without anaesthetic; topical cream can be applied on request. **Eye area mesotherapy (4,900 Kč):** The periorbital zone receives a specialised formulation suited to the thinner, more delicate skin around the eyes — typically higher HA content and lower acid concentrations than face mesotherapy. Addresses dark circles (where the improvement is greatest in vascular or hydration-related dark circles rather than pigmentary ones), under-eye crepiness, and fine wrinkles. Requires a very light touch and fine-gauge needles to avoid bruising this highly vascular area. **Face mesotherapy (from 3,000 Kč):* Full-face treatment improves general skin radiance, hydration, and elasticity. The cocktail is customised — a deeper hydration cocktail for dehydrated skin, a brightening formulation for dull/pigmented skin, or a firming blend for skin laxity. **Course recommendation:** Most patients notice the best outcomes from a series of 3–4 sessions spaced 3–4 weeks apart, followed by maintenance every 3–6 months. **Post-treatment:** Micro-papules visible for up to 48 hours; mild redness. Avoid sun exposure, saunas, and harsh skincare for 5 days. Makeup can be applied the following day.