Type
Mesotherapy
Duration
40 min
What's included
4 deliverables in this treatment
- Physician assessment and PDRN formulation selection
- Topical anaesthetic application
- PDRN injection via fine needle into agreed zones
- Post-treatment soothing and aftercare
PDRN (polydeoxyribonucleotide) biostimulation uses concentrated DNA fragments extracted from wild salmon and injected via fine needle into the face, neck, décolletage or hands. The DNA extract is biocompatible with human tissue and works by binding to adenosine receptors on skin cells, stimulating fibroblast proliferation and collagen synthesis. Results include visible lifting, tightening, improved skin elasticity, pore minimisation and reduction in dark circles — with improvement from the first session and progressive gains over a course of two to four treatments.
About this treatment
Polynucleotides (PDRNs) are long-chain DNA fragments derived from the sperm cells of wild Pacific salmon, selected because salmon DNA shares a very high degree of structural homology with human DNA — making it biocompatible and non-allergenic for injection into human tissue. The PDRN molecule acts through two primary mechanisms in the skin.
The first mechanism is purinergic receptor agonism: PDRN fragments are metabolised to adenosine, which binds to A2A receptors on fibroblasts, endothelial cells and macrophages. A2A receptor activation has a documented anti-inflammatory and pro-regenerative effect — reducing the inflammatory cytokine environment in damaged or aged skin and switching the cellular programme towards repair and remodelling. This is why PDRNs have also been studied in wound…
The second mechanism is a direct mitogenic effect: polynucleotide fragments are incorporated into the PDRN salvage pathway, providing precursor material for DNA synthesis that supports accelerated cell turnover and proliferation in the treated zone. The combination of anti-inflammatory A2A agonism and direct DNA precursor provision produces a biostimulatory environment that drives fibroblasts to produce more collagen and elastin than they would under…
Good to know
- Material
- Wild salmon PDRN — DNA extract biocompatible with human tissue
- Mechanism
- A2A adenosine receptor agonism + DNA precursor provision
- Course
- 2–4 sessions, 2–4 weeks apart
- Results from
- First session; full effect at 2–3 weeks
Who is this for?
Adults seeking cellular-level skin biostimulation for lifting, tightening, elasticity and pore minimisation — particularly suitable for sensitive or reactive skin types
Preparation required
Avoid blood-thinning medications 24 hours before. Arrive with clean skin. Inform the doctor of any fish or DNA-related allergies.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
75 clinic reviews
From independent platforms
Clinical team
Artmedica Clinic is founded and led by MUDr. Kateřina Adamcová, an ENT surgeon trained at Charles University's 3rd Medical Faculty in Prague, who subsequently obtained international certification in aesthetic and anti-aging medicine. She is one of only three officially certified APTOS thread-lift trainers in the Czech Republic and holds membership in the SELM (Society of Aesthetic and Laser Medicine), IMCAS Academy…
Languages: Czech, English
What clients say
"Hair mesotherapy at Artmedica completely changed my hair quality. After three sessions my hair was visibly stronger and stopped falling out so dramatically. I recommend to everyone. — Veronika, site testimonial"
"I had hyaluronic acid lip augmentation and I am very happy with the result — natural, tasteful and exactly what I wanted. The whole team was professional and made me feel completely at ease. — Jana, site testimonial"
Treatment highlights
- Physician assessment and PDRN formulation selection
- Topical anaesthetic application
+2 more items in What's included
1 ml: 7,000 Kč per session; 2 ml: 10,000 Kč per session. 3-session course (1 ml each): 14,000 Kč; 3-session course (2 ml each): 21,000 Kč. 2–4 sessions recommended, spaced 2–4 weeks apart.