Type
Mesotherapy
Duration
45 min
What's included
4 deliverables in this treatment
- Pre-treatment skin assessment and zone mapping by MUDr. Vojtková
- Anaesthetic cream application for comfortable injection
- Polynucleotide solution injection into all agreed zones
- Post-procedure soothing care and written aftercare instructions
Polynucleotide (PDRN/PN) biostimulation at Medest uses injectable DNA fragments derived from wild Korean salmon milt — highly purified and extensively biocompatibility-tested — to activate the skin's natural repair mechanisms from within. The polynucleotides bind to adenosine receptors in skin cells, triggering a cascade of regenerative processes: increased hydration, improved structural integrity, collagen and elastin stimulation, and measurable anti-inflammatory and antioxidant activity. Unlike hyaluronic acid fillers that add volume mechanically, polynucleotides work biologically — they do not fill or volumise but instead restore the functional quality of skin that has thinned or lost resilience with age. MUDr. Vojtková applies the treatment to the eye area, face, neck, and décolleté with results developing gradually over several weeks.
About this treatment
Polynucleotides are long-chain DNA molecules — specifically PDRN (polydeoxyribonucleotide) fragments — extracted from the milt (semen) of wild Pacific salmon (Oncorhynchus keta). The choice of salmon milt is not arbitrary: the DNA sequence similarity between salmon and human cells is sufficiently close that the body does not mount an immune response, while the production and purification process ensures complete removal of proteins that could cause…
Good to know
- Active ingredient
- PDRN polynucleotides from wild Korean salmon
- Mechanism
- A2A receptor activation → collagen + HA synthesis
- Session time
- 30–45 minutes
- Recommended course
- 2–3 sessions, 2–4 weeks apart
Who is this for?
Skin quality improvement (hydration, firmness, luminosity), thin periorbital skin, fine rhytides, neck and décolleté texture, early photoageing
Preparation required
No smoking for at least 48 hours before and after treatment. Remove all makeup before arriving. Avoid blood-thinning medication 48 hours prior. No sauna or intense exercise for one week post-treatment.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
7 clinic reviews
From independent platforms
Clinical team
MUDr. Jelena Vojtková (formerly MUDr. Jelena Labuťová) graduated from the 1st Medical Faculty of Charles University Prague in 1996 and completed her specialist certification in General Practice in 1999. She holds a Diploma of Lifelong Education and is a member of the Czech Medical Chamber, the Society of General Medicine (ČLS JEP), and the Association of General Practitioners of the Czech Republic. Since founding…
Languages: cs, en, ru
What clients say
"{"author":"Dan223","text":"Very kind doctor and an absolute professional. Despite initial fear, I soon knew I was in the right place.","source":"estheticon.cz"}"
"{"author":"TezVonCZ","text":"Very satisfied with the doctor — kind and professional.","source":"estheticon.cz"}"
Treatment highlights
- Pre-treatment skin assessment and zone mapping by MUDr. Vojtková
- Anaesthetic cream application for comfortable injection
+2 more items in What's included
Eye area: 6 500 Kč per session; package of 3 sessions 18 000 Kč (saving 1 500 Kč). Face: 8 500 Kč per session; package of 3 sessions 24 000 Kč (saving 1 500 Kč). Neck and décolleté: 8 500 Kč per session; package of 3 sessions 24 000 Kč. Includes anaesthetic cream, injection, and aftercare guidance.