Polynucleotide Biostimulation PDRN

PDRN polynucleotide biostimulation at MEDICOM Clinic Brno, using highly purified DNA fragments derived from salmon sperm to activate fibroblast proliferation, accelerate collagen synthesis, and improve tissue hydration. A regenerative injectable therapy for skin quality rather than volume or wrinkle correction.

Polynucleotide biostimulation with PDRN (polydeoxyribonucleotide) at MEDICOM Clinic Brno represents a class of regenerative injectables distinct from conventional hyaluronic acid fillers or neurotoxins. Where fillers add mechanical volume and neurotoxins inhibit muscle contraction, PDRN works at the cellular level — stimulating the body's own repair and regeneration pathways rather than introducing a synthetic structural material. PDRN consists of highly purified DNA fragments (50–2,000 base pairs) extracted from the sperm of Pacific salmon (Oncorhynchus mykiss). The biological mechanism centres on the A2A adenosine receptor (A2AR) pathway: PDRN binds to A2AR on fibroblasts, keratinocytes, and endothelial cells, triggering downstream signalling that promotes cell proliferation, collagen and elastin synthesis, hyaluronic acid production, and angiogenesis (formation of new blood vessels). This makes it particularly valuable for tissue with compromised repair capacity — aged, sun-damaged, or post-procedural skin. Clinically, PDRN improves skin hydration, elasticity, and luminosity without adding structural volume. It is typically administered via multiple superficial intradermal microinjections across the face, neck, décolleté, or hands. The injection technique is similar to skin booster protocols — a grid or linear fanning pattern distributing the product evenly across the treatment zone. Sessions are planned as a course: three to four treatments spaced two to four weeks apart are recommended for initial biostimulation, followed by maintenance sessions every three to six months. PDRN is frequently combined with other aesthetic treatments. It is used post-laser or post-microneedling to support tissue healing, paired with botulinum toxin to address quality alongside dynamic lines, or used as a standalone protocol for patients who want skin improvement without the downtime of energy-based procedures. The safety profile is excellent — as a highly purified, non-animal-source nucleotide extract, allergic reactions are extremely rare.