Mesotherapy

Mesotherapy at Poliklinika Sever's Eye Care & Aesthetics Centre involves the intradermal microinjection of active ingredients — vitamins, hyaluronic acid, amino acids, antioxidants, or peptides — directly into the target skin layer using fine needles or a mesotherapy gun. Performed by MUDr. Kim Štěpánková FEBO DiS., the technique bypasses the skin's epidermal barrier to deliver concentrated active substances precisely where collagen remodelling and hydration are needed. At 1,000–2,000 Kč per ampule depending on the product selected, mesotherapy at this clinic is positioned as a scientifically grounded skin rejuvenation and hair-restoration adjunct, commonly combined with botulinum toxin or filler treatments for a comprehensive facial refreshment.

Scalp mesotherapy with Dermaheal HL serum delivers a complex of 56 bioactive ingredients — including biotin, peptides, growth factors, vitamins and amino acids — directly into the scalp via fine micro-injections. This bypasses the stratum corneum barrier that limits topical hair products, placing the active ingredients in immediate contact with hair follicles and the dermal papilla. The treatment supports hair follicle nutrition, improves scalp micro-circulation and may help reduce hair loss while stimulating dormant follicles toward active growth. At DermaClinique Písek, scalp mesotherapy is administered by MUDr. Jůzlová, Ph.D., using Dermaheal HL — a Korean-formulated serum produced for medical mesotherapy use.

Stem C'rum scalp mesotherapy uses a premium serum containing stem cell-derived growth factors and bioactive peptides to revitalise hair follicles and support new growth. The Stem C'rum serum (Stem Cell HL series) is a step above the Dermaheal HL formulation — it specifically incorporates stem cell conditioned medium, which contains the paracrine signalling molecules (cytokines, exosomes and growth factors) released by stem cells during culture. These signals activate follicular stem cells in the bulge region of the hair follicle — the reservoir of hair-regenerating capacity. At DermaClinique Písek, this premium treatment is administered by MUDr. Jůzlová, Ph.D. for patients wanting the highest-grade scalp biostimulation available.

Microinjection of vitamins, minerals, amino acids and hyaluronic acid directly into the mesodermal layer of the skin or scalp, delivering active nutrients where topical products cannot reach. At DermaMedEst mesotherapy is offered for facial and neck rejuvenation, décolletage revitalisation and scalp alopecia management. The scalp protocol offers pack pricing for sustained hair-loss treatment. Hyaluronic acid mesotherapy targets deep skin hydration and is priced separately due to the higher-grade active substance used.

Mesotraduction (electroporation) at Miracle Esthetic Clinic delivers concentrated active ingredients deep into target tissue without needles, using phototherapy-driven biochemical penetration through the Meso T8 device. Up to 90% of active compounds — in paraben-free, petroleum-free, fragrance-free specialised gels — reach the target tissue depth versus less than 5% from topical application. Body applications include anti-cellulite, slimming, toning, breast firming, and intensive stretch mark treatment. The treatment is completely painless, requires no recovery time, and produces visible improvement after the first session.

PDRN-VITARAN is a Korean polynucleotide (PDRN — polydeoxyribonucleotide) biostimulator derived from salmon DNA fragments. When micro-injected into the periorbital area, the polynucleotide molecules bind to specific receptors (A2A adenosine receptors) in skin fibroblasts, triggering cellular regeneration, collagen synthesis and improved micro-circulation. The eye area treatment targets crow's feet, under-eye fine lines, dark circles caused by poor micro-circulation, and skin thinning in the periorbital zone — one of the earliest and most delicate areas to show age-related change. At DermaClinique Písek, 1 ml is used per session, administered by MUDr. Jůzlová, Ph.D.

Mesotraduction Face delivers concentrated skin-active ingredients — hyaluronic acid, brightening agents, collagen peptides, lifting complexes, or regenerative factors — directly into the dermis using the Meso T8 electroporation device. With up to 90% ingredient penetration versus less than 5% from topical application, mesotraduction face treatments provide an injection-level efficacy profile without any needles, discomfort, or skin trauma. Multiple protocols are available at Miracle Esthetic Clinic targeting specific skin concerns: deep hydration, lifting, brightening, acne-prone skin, regeneration, and neck rejuvenation.

Intradermal microinjection of skin-revitalising cocktails containing vitamins, amino acids, peptides and hyaluronic acid to deeply hydrate and stimulate collagen and elastin production in the face, neck, décolletage and backs of hands. Mesotherapy reaches the mesodermal layer of the skin directly, bypassing the epidermal barrier that limits what topical products can achieve. Each session delivers concentrated active ingredients exactly where ageing has depleted them, triggering a renewal cascade that produces measurable improvements in skin texture, firmness and luminosity over a course of treatments.

Injectable mesotherapy at Lili Clinic delivers high-concentration hyaluronic acid, vitamins, amino acids, and coenzymes directly into the dermis using a cannula technique — approximately 10 entry points around the face — reducing trauma compared to multi-needle approaches. The 45-minute procedure intensely hydrates and revitalises skin at the cellular level, stimulating collagen and elastin production. Patients return to social activities by day 2 with only mild redness or swelling.

Intravenous vitamin infusion therapy delivering high-dose vitamin C, B-complex vitamins, magnesium, calcium, glutathione and citicoline directly into the bloodstream for immediate absorption — bypassing the digestive system entirely. Three curated protocols target different goals: Vitality, Immunity and Energy for chronic fatigue and frequent infections; Prevention First with glutathione for antioxidant and detox support; and Stress Killer with glutathione and citicoline for cognitive performance and nerve cell protection. Available at Artmedica Clinic Prague with medical oversight.

Biorevitalization at Follow Clinic delivers hyaluronic acid and supporting nutrients directly into the skin via micro-injections for intensive hydration and radiance at the cellular level. Treating the face alone is 4,200 Kč; combining face, neck, and décolletage in a single session is 8,900 Kč — covering the full extent of visible aging skin efficiently and cost-effectively. A series of 3 sessions spaced 2–4 weeks apart is recommended for lasting improvement, with maintenance sessions every 4–6 months. Suitable for all skin types. Minor redness at injection sites resolves within 24–48 hours.

Full-face PDRN-VITARAN biostimulation uses 2 ml of Korean polynucleotide solution micro-injected across the entire face to trigger collagen synthesis, improve micro-circulation and support tissue regeneration. The treatment delivers a higher dose than the eye-area-only protocol, providing whole-face skin quality improvement: reduced fine lines, improved elasticity, brighter complexion and more even skin tone. PDRN (polydeoxyribonucleotide) works at a cellular level by activating fibroblast regeneration pathways — distinct from hyaluronic acid hydration alone. At DermaClinique Písek, MUDr. Jůzlová, Ph.D. administers the treatment using precise micro-injection technique built on her hospital-level injectable medicine training.

A scalp mesotherapy treatment using INNO-TDS Hair Loss Control — a pharmaceutical-grade cocktail of hair growth factors, vitamins, and follicle-stimulating compounds — delivered via multiple microinjections directly into the scalp dermis. Unlike topical products that struggle to penetrate the scalp barrier, mesotherapy places active ingredients exactly where hair follicles are anchored. At Medianna Clinic, the procedure is performed by experienced medical staff, with the INNO-TDS range representing a clinically validated Spanish pharmaceutical protocol widely used across European dermatology practices for androgenic alopecia and diffuse hair thinning.

A nourishing scalp mesotherapy treatment using INNO-TDS Hair Vital — a pharmaceutical cocktail formulated for hair lacking density, shine, and vitality rather than active androgenic hair loss. While Hair Loss Control targets the hormonal and microcirculatory drivers of pattern baldness, Hair Vital is a comprehensive follicle-nutrition protocol for hair that is thinning due to stress, nutritional gaps, post-illness shedding, or environmental factors. At Medianna Clinic, both INNO-TDS formulations are available, allowing the physician to select or combine the appropriate protocol based on each patient's hair loss type.

Xela Rederm is a Swiss-developed injectable skin booster combining hyaluronic acid with amber acid (sodium succinate) — a Krebs cycle metabolite that stimulates fibroblasts to produce collagen and elastin independent of any external laser or RF energy. The injected formula simultaneously provides deep hydration (from the HA component) and active cellular regeneration (from the succinate component), producing visibly smoother, firmer and more radiant skin within three days. Artmedica Clinic Prague was the first clinic in the Czech Republic to offer Xela Rederm, positioning it as an early adopter of this Swiss aesthetic innovation.

Skin revitalisation mesotherapy delivering customised cocktails of hyaluronic acid, vitamins, minerals, antioxidants and nucleic acids by microinjection directly into the mesodermal skin layer. At Artmedica Clinic Prague a single-point cannula or a 9-needle injector delivers the formula in a structured pattern across face, neck, eye area, décolletage or hands. The intradermal delivery bypasses the skin barrier entirely, achieving concentrations of active ingredients that topical products cannot reach. Results include improved elasticity, hydration, skin appearance and collagen stimulation with minimal downtime.

Profhilo bioremodeling delivers a unique combination of high and low molecular weight hyaluronic acid via just ten injection points using the BAP (Bio Aesthetic Points) technique. Unlike standard dermal fillers it does not add volume or structure — it stimulates the skin's own production of collagen, elastin and HA for firmer, more elastic and visibly hydrated skin. The two-session protocol (one month apart) produces gradual improvement in skin quality that continues to develop for weeks after the final session. Artmedica Clinic Prague offers both standard Profhilo and the Profhilo Structura variant for deeper tissue remodelling.

Mesotherapy at BESTÉE Clinic delivers targeted active compounds — hyaluronic acid, collagen, polynucleotides, or a multi-ingredient booster complex — via fine-needle microinjections into the superficial dermis, bypassing the skin barrier to achieve direct tissue-level results. The clinic offers four distinct formulas: a 5ml Booster for dehydrated or fatigued skin, 1ml Hyaluronic Acid for structural restoration and fine-line smoothing, 2ml Collagen for immediate contour improvement lasting 12–18 months, and 1.5ml Nucleofill for cell-level biostimulation with antioxidant and hydration benefits. Treatment is suitable for face, neck, décolletage, and body areas.

Skin and scalp rejuvenation using the patient's own platelet-rich plasma (PRP), prepared from a small venous blood draw and reinjected into the face, neck, décolletage, hands or scalp. PRP contains concentrated growth factors — PDGF, TGF-beta, VEGF and IGF — that stimulate collagen synthesis, improve tissue quality and, on the scalp, support follicular activity. Because the plasma is autologous, rejection and allergic reactions are not a concern. DermaMedEst's protocol draws 20 ml of blood, centrifuges it to concentrate platelets, and injects the resulting plasma into the target area.

Profhilo at Skinity Clinic is the highest-concentration HA bioremodelling injectable currently available in Europe — a 64 mg/2 mL formulation of thermally stabilised hyaluronic acid that is not cross-linked in the traditional filler sense. Rather than creating volume or projection, Profhilo disperses through the tissue hydrating, tightening, and remodelling the skin architecture at the cellular level. MUDr. Martin Bortlík administers it using the BAP (bio-aesthetic points) protocol — five anatomically defined injection points per cheek — that distribute the product through the tissue's natural hydraulic pressure. The result is improved skin quality, elasticity, firmness, and a luminous skin tone that emerges progressively over 4–8 weeks as the four types of collagen and elastin stimulation take effect. The standard treatment is 2 sessions 4 weeks apart.

PDRN (polydeoxyribonucleotide) biostimulation uses concentrated DNA fragments extracted from wild salmon and injected via fine needle into the face, neck, décolletage or hands. The DNA extract is biocompatible with human tissue and works by binding to adenosine receptors on skin cells, stimulating fibroblast proliferation and collagen synthesis. Results include visible lifting, tightening, improved skin elasticity, pore minimisation and reduction in dark circles — with improvement from the first session and progressive gains over a course of two to four treatments.

Profhilo is a 97% hyaluronic acid bioremodeling injectable at Follow Clinic that stimulates elastin and collagen production throughout the skin, improving overall skin quality rather than targeting specific lines or adding volume. Two sessions administered 4 weeks apart are recommended at a combined cost of 15,000 Kč. Each 2 ml syringe contains 64 mg of HA and spreads up to 2 cm from each of the 5 BAP injection points, making it one of the most efficient skin boosters available. Results last 6–12 months and can be applied to the face, neck, chest, arms, hands, or knees.

PRP Plasmalifting at Petra Clinic uses the patient's own platelet-rich plasma to rejuvenate the skin through natural growth-factor stimulation. A small blood sample is drawn, centrifuged in the clinic's REGEN preparation system to concentrate platelets to three to five times physiological levels, then applied via multiple microinjections into the dermis of the face, neck or scalp. Platelets release a cocktail of growth factors — PDGF, TGF-β, VEGF, EGF — that activate resident fibroblasts, stimulate collagen and elastin synthesis, and improve tissue hydration. Because the treatment uses the patient's own biological material, the risk of allergic reaction is essentially zero. Two days without makeup is the typical post-treatment precaution; effects last up to twelve months.

Mesotherapy at Petra Clinic delivers a customised cocktail of active substances — vitamins, minerals, amino acids, hyaluronic acid, antioxidants and optionally the patient's own plasma — directly into the mid-dermis through multiple fine microinjections. By bypassing the skin barrier, mesotherapy concentrates bioactive molecules at the site where fibroblasts, keratinocytes and microvascular endothelium are actively metabolising, producing improvements in hydration, skin quality, brightness and fine-line reduction that topical application cannot replicate. The specific cocktail is tailored by the physician to the individual's skin condition, age and goals. A course of two to three sessions per year maintains and advances the benefit.