Hair Mesotherapy with Stem C'rum Serum — Single Session

Stem C'rum scalp mesotherapy uses a premium serum containing stem cell-derived growth factors and bioactive peptides to revitalise hair follicles and support new growth. The Stem C'rum serum (Stem Cell HL series) is a step above the Dermaheal HL formulation — it specifically incorporates stem cell conditioned medium, which contains the paracrine signalling molecules (cytokines, exosomes and growth factors) released by stem cells during culture. These signals activate follicular stem cells in the bulge region of the hair follicle — the reservoir of hair-regenerating capacity. At DermaClinique Písek, this premium treatment is administered by MUDr. Jůzlová, Ph.D. for patients wanting the highest-grade scalp biostimulation available.

Stem C'rum (also referred to as Stem Cell HL serum) represents the premium tier of scalp mesotherapy available at DermaClinique Písek. While Dermaheal HL provides a comprehensive micronutrient and growth factor complex, Stem C'rum specifically incorporates stem cell conditioned medium (SCM) — the bioactive secretome of cultured stem cells. **What is stem cell conditioned medium?** When stem cells are cultured in a laboratory, they secrete a rich mixture of paracrine signalling molecules into the surrounding medium: growth factors (EGF, KGF, HGF, IGF-1), cytokines, exosome-packaged microRNAs, and matrix metalloproteinase inhibitors. This conditioned medium can be harvested, standardised, and incorporated into a mesotherapy serum — delivering stem cell-type signalling without using actual living cells. The biological effect is to 'instruct' resident follicular stem cells in the scalp to re-enter active growth cycles. **Follicular stem cell biology:** Hair follicles contain a reservoir of stem cells in the 'bulge' region. In androgenetic alopecia and age-related thinning, these stem cells are progressively less effectively activated at the start of each anagen cycle — follicles miniaturise (produce thinner, shorter hair) before eventually ceasing production. Stem cell conditioned medium signals may partially restore follicular stem cell activation, extending anagen duration and reversing miniaturisation in early-to-moderate hair loss. **Differences from Dermaheal HL:** Both products are injected using the same scalp mesotherapy technique. The key distinction is that Stem C'rum's active component — stem cell conditioned medium — provides a richer paracrine signalling environment than conventional growth factors. This makes it theoretically more potent for follicular stem cell activation, which is why it is priced higher and positioned as the premium option. Patients with moderate-to-significant hair loss, or those who want the highest-grade biostimulation, typically opt for Stem C'rum. **What to expect during the session:** The session follows the same protocol as Dermaheal HL mesotherapy. The scalp is cleansed; MUDr. Jůzlová administers the Stem C'rum serum via systematic micro-injections across the thinning areas. The session takes 35–45 minutes. Post-treatment sensations (mild tenderness, pinpoint bleeding) are the same as with Dermaheal HL. **Protocol:** The 5-session package (6 000 Kč, saving 1 500 Kč vs single sessions) is recommended for a clinically meaningful course. Sessions typically monthly. Results are assessed at the 3-month and 6-month mark — hair diameter and density improvement are the key markers. **Comparison — when to choose Stem C'rum over Dermaheal HL:** - **Dermaheal HL (1 200 Kč/session):** Comprehensive micronutrient and conventional growth factor complex; cost-effective first-line choice for early thinning or maintenance - **Stem C'rum (1 500 Kč/session):** Premium stem cell conditioned medium; preferred for moderate-to-significant loss, patients who have tried Dermaheal HL with partial response, or those wanting the highest-grade available formulation **Contraindications and aftercare:** As per Dermaheal HL — active scalp infection, psoriasis, seborrhoeic dermatitis in the area, allergy to serum components, pregnancy. Avoid hair washing for 12 hours, pools/saunas for 24 hours.