Type
Mesotherapy
Duration
30 min
What's included
3 deliverables in this treatment
- 1 ml PDRN-VITARAN injection administered around the periorbital area
- Pre-treatment skin assessment and contraindication review
- Post-injection aftercare instructions
PDRN-VITARAN is a Korean polynucleotide (PDRN — polydeoxyribonucleotide) biostimulator derived from salmon DNA fragments. When micro-injected into the periorbital area, the polynucleotide molecules bind to specific receptors (A2A adenosine receptors) in skin fibroblasts, triggering cellular regeneration, collagen synthesis and improved micro-circulation. The eye area treatment targets crow's feet, under-eye fine lines, dark circles caused by poor micro-circulation, and skin thinning in the periorbital zone — one of the earliest and most delicate areas to show age-related change. At DermaClinique Písek, 1 ml is used per session, administered by MUDr. Jůzlová, Ph.D.
About this treatment
PDRN (polydeoxyribonucleotide) technology was originally developed in wound healing and burns medicine before aesthetic applications were established. PDRN-VITARAN (HP VITARAN) is a Korean biostimulator product using highly purified salmon-derived polynucleotides — short double-stranded DNA fragments that, when injected into the dermis, activate the A2A adenosine receptor pathway.
Mechanism
Activation of the A2A receptor stimulates fibroblasts to upregulate collagen and extracellular matrix production, promotes angiogenesis (new blood vessel formation, which improves tissue nutrition and reduces dark circles caused by vascular stasis), and triggers wound-repair cascades that accelerate tissue regeneration. Unlike hyaluronic acid, which acts primarily as a hydration reservoir, PDRN drives active biological repair at the cellular level.
Good to know
- Product
- HP VITARAN (salmon PDRN)
- Dose
- 1 ml per session
- Treatment area
- Periorbital / eye contour
- Sessions
- 2–3 × 2–4 weeks apart
Who is this for?
Crow's feet, under-eye fine lines, dark circles (vascular), periorbital skin thinning, early eye-area ageing
Preparation required
Avoid aspirin and ibuprofen 1 week before. Arrive without eye make-up. EMLA numbing cream available for +100 Kč — request at booking.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
Clinical team
DermaClinique Písek is founded and led by MUDr. Kateřina Jůzlová, Ph.D. She graduated from the 1st Medical Faculty of Charles University, completed her dermatovenerology residency and worked at the dermatovenerology clinic at Na Bulovce Hospital (2009–2017) and then at the dermatovenerology ambulance at IKEM (2015–2017), contributing to teaching, research and clinical studies. She was awarded her Ph.D. from the 2nd…
Languages: Czech
Treatment highlights
- 1 ml PDRN-VITARAN injection administered around the periorbital area
- Pre-treatment skin assessment and contraindication review
+1 more item in What's included
2 500 Kč per session (1 ml PDRN-VITARAN product). Recommended course is 2–3 sessions spaced 2–4 weeks apart, totalling 5 000–7 500 Kč. Maintenance sessions every 3–6 months.