Redermalization — Xela Rederm (Swiss)

Redermalization is a term coined by Hyalual — the Swiss pharmaceutical company behind the Xela Rederm product line — to describe the process of restoring the full dermal matrix rather than simply adding temporary hydration. Standard HA skin boosters hydrate effectively but do not inherently stimulate new structural protein synthesis. Xela Rederm's distinguishing component is sodium succinate, the salt of succinic acid (amber acid), which is an endogenous…

When sodium succinate is delivered into the dermis at therapeutic concentrations, it acts as a mitochondrial activator and antioxidant in the local fibroblast population: it increases ATP production, reduces oxidative stress, and upregulates the fibroblasts' own synthesis of collagen, elastin and native hyaluronic acid. This means the product doesn't just physically fill the space — it biologically reactivates the skin's own regenerative capacity in the…

The hyaluronic acid component provides the structural hydration matrix within which the sodium succinate acts: as HA attracts and binds water molecules, the dermal environment becomes better hydrated and the tissue swells slightly, further stretching fibroblasts and mechanically stimulating collagen synthesis through integrin pathways. The combination creates a synergistic effect that neither component achieves as effectively in isolation.