PDRN-VITARAN Full Face Biostimulation

Full-face PDRN-VITARAN biostimulation uses 2 ml of Korean polynucleotide solution micro-injected across the entire face to trigger collagen synthesis, improve micro-circulation and support tissue regeneration. The treatment delivers a higher dose than the eye-area-only protocol, providing whole-face skin quality improvement: reduced fine lines, improved elasticity, brighter complexion and more even skin tone. PDRN (polydeoxyribonucleotide) works at a cellular level by activating fibroblast regeneration pathways — distinct from hyaluronic acid hydration alone. At DermaClinique Písek, MUDr. Jůzlová, Ph.D. administers the treatment using precise micro-injection technique built on her hospital-level injectable medicine training.

The full-face PDRN-VITARAN treatment extends the polynucleotide biostimulation protocol to cover the complete facial surface — cheeks, forehead, perioral area, chin and jaw — using 2 ml of HP VITARAN salmon-derived PDRN solution. This comprehensive dosing ensures fibroblast activation across the full dermal network rather than targeting isolated zones. **Mechanism — same science, whole face:** PDRN molecules activate the A2A adenosine receptor on skin fibroblasts, stimulating: - Collagen and elastin synthesis (structural matrix rebuilding) - Angiogenesis (improved capillary circulation → better nutrition and glow) - Wound-repair cascade (accelerated cellular renewal) - Anti-inflammatory modulation (relevant for acne-prone and reactive skin) The result is a progressive improvement in overall skin quality rather than correction of a specific lesion — the equivalent of a biological 'reset' of the dermis rather than a topical brightening product. **Differences from the eye-area protocol:** The full-face treatment uses twice the product volume (2 ml vs 1 ml), covers a significantly larger injection map and takes proportionally longer to administer. The biological mechanisms and protocol are identical; the scope and cost differ. **What to expect during the session:** EMLA topical anaesthetic may be applied 30 minutes beforehand (available for an additional 100 Kč). MUDr. Jůzlová administers the PDRN-VITARAN across the face in a systematic pattern covering the key treatment zones. The session including preparation takes approximately 45–55 minutes. Post-treatment, the skin looks slightly red and bumpy for 1–2 hours; this resolves completely. Some patients experience minor bruising. **Results timeline:** Skin texture improvement begins to appear within 2–3 weeks of the first session as fibroblast activity increases. Visible firmness, glow and fine-line softening build progressively over the course of 2–3 sessions. The full effect is assessed at 6–8 weeks after the final session in the primary course. **Protocol:** 2–3 sessions at 2–4 week intervals. Maintenance injections every 3–6 months preserve the regenerated tissue quality. Can be combined with other clinic treatments (Prophilo for bio-remodelling, Hollywood Laser for surface texture, DermaOxy for deep hydration) with appropriate intervals. **Summer suitability:** PDRN does not increase photosensitivity, making it a practical treatment option during warmer months when laser and chemical peel treatments require sun avoidance. **Contraindications:** Fish/salmon allergy, active facial infection, pregnancy, breastfeeding, autoimmune conditions (discuss with doctor). Blood thinners increase bruising risk — inform the doctor at booking. **Aftercare:** Avoid make-up for 12 hours. No direct sun for 24 hours. Use SPF 50 for 1 week post-treatment.