Mesotherapy — Skin Rejuvenation and Rehydration

Mesotherapy was developed by French physician Michel Pistor in the 1950s as a technique for delivering therapeutic agents locally into the mesoderm — the middle layer of embryonic tissue from which skin's connective structures, blood vessels and adipose tissue derive. In aesthetic practice today it refers to a series of very superficial microinjections (0.5–4 mm depth) placed across the treatment zone using a fine-gauge needle or multi-needle device,…

The logic is pharmacokinetic: the stratum corneum limits topical penetration of most large molecules. Even well-formulated serums deliver a small fraction of their active concentration into the dermis. Microinjection bypasses this barrier entirely, depositing the full dose of active ingredients exactly where collagen-producing fibroblasts reside and where the skin's hydration infrastructure — the glycosaminoglycan matrix — has been degraded by age and…

At MUDr. Brychtová's practice the mesotherapy cocktails are selected according to the presenting concern. For deep rehydration and a luminosity boost, the formulation centres on non-cross-linked hyaluronic acid, which integrates into the dermal matrix and creates a hydration reservoir that plumps and brightens skin within days of the first session. For anti-ageing and firming, peptide-enriched cocktails with growth factors and vitamins (particularly…