Mesotherapy in Prague

Hyaluronic acid skinbooster injections at CLED deliver a hydrating HA preparation with built-in lidocaine directly into the mid-dermis, creating a deep moisture reservoir that plumps and revitalises from within — an effect that topical serums cannot replicate. A single session takes up to 20 minutes and the deep hydration lasts 9–12 months. Treatment areas include face, hands, neck and décolletage. The gradual onset over three weeks means no immediate swelling visible to others, making it suitable for patients with no downtime.

Microinjection of vitamins, minerals and hyaluronic acid for facial rejuvenation.

Décolletage rejuvenation at S-thetics Beauty uses hyaluronic acid injections to improve the skin texture and reduce wrinkles of the chest and neckline area. The décolletage is chronically sun-exposed, often thinner-skinned than the face, and subject to vertical fold creases from sleep posture — all of which accelerate the appearance of ageing wrinkles, crepey texture, and pigmentation. MDDr. Šanšašvili uses a micro-injection technique across the chest area to deliver HA at the dermal level, providing deep hydration, improved elasticity, and a reduction in surface wrinkling. The treatment is available in 1 ml (5,500 Kč) or 2 ml (10,500 Kč) options depending on the area to be treated. A series of two to three sessions is recommended for optimal cumulative skin quality improvement.

PRP Plasmatherapy at Beauty Clinic Synergy uses the Swiss RegenLab system to process a patient's own blood into a concentrated platelet-rich plasma and reintroduce it by injection into the face, scalp, neck, hands or body. The RegenLab protocol activates approximately 90 per cent of growth factors — roughly three times more than classic centrifuge methods — and yields approximately 5 ml of therapeutic plasma per draw. Physician-administered injections deliver the growth factors directly to fibroblasts and dermal tissue, stimulating collagen production, improving skin texture and reducing fine lines and scars over a course of 3–5 sessions.

Injectable lipolysis at Follow Clinic uses a phosphatidylcholine/deoxycholate compound injected directly into subcutaneous fat deposits to permanently destroy and dissolve localized fat cells. Targeted areas include the submental chin (from 3,500 Kč per session), abdomen and flanks (from 5,500 Kč), and inner thighs (from 7,200 Kč). Multi-session packages offer significant savings: up to 3 sessions for the abdomen at 15,000 Kč. Two to three sessions are typically needed for optimal contouring results. Swelling and redness in the treated area are expected for 1–2 weeks. Performed by a doctor.

PRP (platelet-rich plasma) therapy at ISCARE's dermatology department uses the patient's own blood, centrifuged to concentrate growth factors, which are then micro-injected into the face or scalp to stimulate collagen production and tissue regeneration. At 5,500 Kč per session and administered by dermatologists, ISCARE's PRP service uses a clinical-grade centrifuge to produce a consistent, high-quality plasma fraction, and targets skin texture, fine lines, and hair thinning.

Xela Rederm is a Swiss-developed injectable skin booster combining hyaluronic acid with amber acid (sodium succinate) — a Krebs cycle metabolite that stimulates fibroblasts to produce collagen and elastin independent of any external laser or RF energy. The injected formula simultaneously provides deep hydration (from the HA component) and active cellular regeneration (from the succinate component), producing visibly smoother, firmer and more radiant skin within three days. Artmedica Clinic Prague was the first clinic in the Czech Republic to offer Xela Rederm, positioning it as an early adopter of this Swiss aesthetic innovation.

Skin revitalisation mesotherapy delivering customised cocktails of hyaluronic acid, vitamins, minerals, antioxidants and nucleic acids by microinjection directly into the mesodermal skin layer. At Artmedica Clinic Prague a single-point cannula or a 9-needle injector delivers the formula in a structured pattern across face, neck, eye area, décolletage or hands. The intradermal delivery bypasses the skin barrier entirely, achieving concentrations of active ingredients that topical products cannot reach. Results include improved elasticity, hydration, skin appearance and collagen stimulation with minimal downtime.

Profhilo bioremodeling delivers a unique combination of high and low molecular weight hyaluronic acid via just ten injection points using the BAP (Bio Aesthetic Points) technique. Unlike standard dermal fillers it does not add volume or structure — it stimulates the skin's own production of collagen, elastin and HA for firmer, more elastic and visibly hydrated skin. The two-session protocol (one month apart) produces gradual improvement in skin quality that continues to develop for weeks after the final session. Artmedica Clinic Prague offers both standard Profhilo and the Profhilo Structura variant for deeper tissue remodelling.

Mesotherapy at Art Ethic delivers a customised cocktail of hyaluronic acid, succinic acid, and vitamins into the skin of the face and décolletage via fine microinjections or microneedling, deeply hydrating and firming the skin at the dermal level. The treatment targets the underlying tissue rather than the skin surface, stimulating natural collagen production and improving elasticity from within. It is well suited to patients in their thirties and forties beginning to notice skin quality changes who want a medically supervised preventive approach, and to those wanting non-surgical skin rejuvenation between or alongside surgical procedures.

Rejuran is a polynucleotide (PN) bio-revitaliser derived from highly purified salmon DNA that acts as a biological skin repair signal rather than simply hydrating or filling the skin. When injected into the mid-dermis, polynucleotides stimulate the skin's own fibroblasts to produce collagen and elastin, promote cell regeneration, improve skin barrier integrity and exert anti-inflammatory effects. At Klinika Kasiopea, MUDr. Bittner delivers Rejuran through microinjections after topical anaesthetic application, targeting fine lines, loss of firmness and skin dehydration on the face, neck, décolletage and around the eyes. A course of three sessions two to four weeks apart is standard.

Mesotherapy at RAJSKA Clinic uses biocompatible injectable blends — Neauvia Organic Hydrodeluxe for facial skin, and scalp-specific formulations and hair polynucleotides for hair loss — to deliver active ingredients directly into the target tissue layer. Neauvia Organic uses high-purity HA from non-animal bacterial fermentation, enriched with hydroxyapatite and glycine for enhanced biocompatibility. Scalp mesotherapy and hair polynucleotides address androgenic alopecia, telogen effluvium, and stress-related hair loss with a nutrient-rich injection protocol that extends the anagen (growth) phase of the hair cycle. A course of at least three sessions is standard.

Profhilo bioremodeling injection — high-concentration HA that hydrates deeply and stimulates collagen and elastin across four skin layers from just five injection points, improving skin quality without adding volume.

Biorevitalization at S-thetics Beauty delivers unsaturated (non-cross-linked) hyaluronic acid directly into the dermis via fine-needle micro-injections to intensely hydrate and rejuvenate the skin from within. Unlike structural fillers, biorevitalization HA is low-viscosity and spreads through the tissue to act as a water reservoir — binding up to 1,000 times its own weight in water and stimulating fibroblast activity for improved collagen and elastin production. The result is improved skin quality: better hydration, finer pores, increased elasticity, and a natural glow that no topical moisturiser can replicate at the same depth. MDDr. Darina Šanšašvili performs the procedure using a series of small superficial injections across the face, neck, or décolletage. A series of three sessions two to four weeks apart is recommended for cumulative benefit; single sessions are also available for those who want a skin-quality boost before an event.

Polynucleotide biostimulation with PDRN (polydeoxyribonucleotide) at DiVine Clinic uses salmon-derived DNA fragments to activate dormant skin cells, stimulate collagen and elastin production, and restore elasticity, firmness, and hydration. Administered by MUDr. Petra Moravcová, PDRN is injected into the target skin zone — eye area, face, or neck and décolletage — where it acts on A2A adenosine receptors to trigger cell proliferation and tissue remodelling pathways. The treatment is an injectable biostimulator rather than a filler — it does not add visible volume but instead improves the quality of the skin's own structural matrix. DiVine Clinic offers courses of three sessions for each zone, with the eye area priced at 6,500 Kč and the face or neck at 8,500 Kč per session. Results are gradual and progressive, with visible improvement in skin elasticity, tone, and firmness over 4–8 weeks per session.

Plasma therapy (PRP) at DiVine Clinic uses the patient's own platelet-rich plasma to stimulate skin regeneration, collagen production, and tissue repair. MUDr. Petra Moravcová draws 8–10 ml of venous blood, centrifuges it to isolate the platelet-rich plasma fraction concentrated with growth factors, and re-injects the PRP into the target skin zone via fine needles or cannulas after numbing cream application. The growth factors released from activated platelets — PDGF, TGF-β, and VEGF — recruit fibroblasts to produce new collagen and elastin and improve local vascularisation. Because PRP is derived from the patient's own blood, the risk of allergy or immune reaction is essentially zero. The treatment is used at DiVine Clinic for facial skin rejuvenation, improved skin radiance, acne improvement, and hair loss treatment. Collagen remodelling begins below the surface within days, with visible skin quality improvement appearing over 6–8 weeks.

Polynucleotide (PDRN) salmon DNA mesotherapy — a biological regenerative treatment injected into the dermis to activate tissue repair, stimulate fibroblasts, improve skin hydration, and reduce fine lines through cell regeneration.

Skin and scalp rejuvenation using the patient's own platelet-rich plasma (PRP), prepared from a small venous blood draw and reinjected into the face, neck, décolletage, hands or scalp. PRP contains concentrated growth factors — PDGF, TGF-beta, VEGF and IGF — that stimulate collagen synthesis, improve tissue quality and, on the scalp, support follicular activity. Because the plasma is autologous, rejection and allergic reactions are not a concern. DermaMedEst's protocol draws 20 ml of blood, centrifuges it to concentrate platelets, and injects the resulting plasma into the target area.

Mesotherapy at Klinika Esthé delivers micro-injections of hyaluronic acid, vitamins and revitalising complexes into the superficial skin layers of the face or eye area to improve hydration, elasticity and overall skin quality. Performed by the clinic's aesthetic medicine physicians, the treatment targets dull, dehydrated or early-ageing skin without altering facial volume or expression, and requires minimal downtime. Sessions cover the face (1 ml or 2 ml product volume) or the delicate eye area, and are commonly delivered as a short series for cumulative biorevitalisation results.

PRP plasma therapy at FaceExpert uses the patient's own blood — drawn, centrifuged to isolate the platelet-rich plasma fraction, and re-injected into the target tissue — to deliver a concentrated payload of growth factors that stimulate collagen production, improve skin quality, and support tissue regeneration. The treatment is completely autologous: because it uses the patient's own plasma, the risk of allergy or immune reaction is essentially zero. FaceExpert performs PRP with either 1 vial (6,900 Kč) or 2 vials (10,900 Kč) of processed plasma depending on the treatment zone and concentration needed. The therapy is used for facial skin rejuvenation, acne scarring, hair loss on the scalp, and general skin quality enhancement. Growth factors from activated platelets — PDGF, TGF-β, VEGF, EGF — trigger fibroblast proliferation, collagen synthesis, and angiogenesis. Visible improvement in skin luminosity and texture appears over 4–8 weeks per session, with 2–3 sessions recommended for sustained results.

PDRN (polydeoxyribonucleotide) biostimulation uses concentrated DNA fragments extracted from wild salmon and injected via fine needle into the face, neck, décolletage or hands. The DNA extract is biocompatible with human tissue and works by binding to adenosine receptors on skin cells, stimulating fibroblast proliferation and collagen synthesis. Results include visible lifting, tightening, improved skin elasticity, pore minimisation and reduction in dark circles — with improvement from the first session and progressive gains over a course of two to four treatments.

Profhilo at Skinity Clinic is the highest-concentration HA bioremodelling injectable currently available in Europe — a 64 mg/2 mL formulation of thermally stabilised hyaluronic acid that is not cross-linked in the traditional filler sense. Rather than creating volume or projection, Profhilo disperses through the tissue hydrating, tightening, and remodelling the skin architecture at the cellular level. MUDr. Martin Bortlík administers it using the BAP (bio-aesthetic points) protocol — five anatomically defined injection points per cheek — that distribute the product through the tissue's natural hydraulic pressure. The result is improved skin quality, elasticity, firmness, and a luminous skin tone that emerges progressively over 4–8 weeks as the four types of collagen and elastin stimulation take effect. The standard treatment is 2 sessions 4 weeks apart.

Jalupro Super Hydro biorevitalization at RAJSKA Clinic combines hyaluronic acid with a proprietary complex of amino acids, vitamins, and antioxidants injected into the superficial dermis to intensively regenerate and rehydrate skin. Unlike pure HA skin boosters, Jalupro's amino acid matrix (glycine, proline, hydroxyproline, lysine) provides direct building blocks for collagen synthesis, making it more than a simple moisturising treatment. Indicated for the face, neck, décolletage, and hands, the treatment visibly brightens and firms skin from the first session, with cumulative improvement across a three-to-four-session course. Particularly effective for sun-damaged, dehydrated, or post-acne skin.

Bioremodeling injections at RAJSKA Clinic — using Profhilo, Structura, or RRS HA LOLA — deliver the highest available concentration of stabilised hyaluronic acid directly into the skin, providing intense hydration combined with a biostimulatory signal to tighten and remodel collagen and elastin. Unlike standard fillers, bioremodeling products spread through the tissue from a small number of bio-aesthetic injection points, treating a large area with minimal needle insertions. The result is a marked improvement in skin quality, firmness, and radiance across the face, neck, décolletage, arms, or above-knee area after just two sessions.