PDRN Mesotherapy — Salmon DNA Skin Rejuvenation

Polynucleotide (PDRN) salmon DNA mesotherapy — a biological regenerative treatment injected into the dermis to activate tissue repair, stimulate fibroblasts, improve skin hydration, and reduce fine lines through cell regeneration.

PDRN (polydeoxyribonucleotide) is a highly purified extract of salmon DNA fragments that has a molecular structure compatible with human purinergic receptors — specifically the A2A adenosine receptor on fibroblasts and keratinocytes. When injected into the dermis, PDRN activates the A2A pathway, which triggers a cascade of regenerative responses: fibroblast proliferation and collagen synthesis, keratinocyte growth factor release, angiogenesis (new capillary formation for improved tissue oxygenation), and anti-inflammatory signalling that reduces chronic low-grade dermal inflammation. The result is what patients and practitioners describe as a 'skin reset' — improvement in skin hydration, elasticity, fine line depth, and overall skin health that goes beyond the surface-level hydration of standard HA mesotherapy. PDRN is particularly effective for patients with photoaged skin, post-acne scarring, sensitive or reactive skin that does not tolerate more aggressive treatments, and patients in the post-procedural recovery phase after ablative or fractional treatments. At Upgrade Clinic, PDRN mesotherapy is priced from 6,500 CZK (260 EUR) per session, with course pricing available. The clinic uses leading PDRN products from Korean manufacturers — the originators of PDRN aesthetic medicine — who hold extensive clinical data supporting the regenerative mechanism. The treatment is administered via superficial microinjections across the target area using a mesotherapy technique, covering the full face in a 30 to 40 minute appointment. PDRN mesotherapy is safe across all skin types with minimal contraindications. The main post-treatment findings are small wheals at injection points that resolve within 12 to 24 hours, and potential mild redness that fades by the following day. A course of four sessions spaced two weeks apart is recommended for initial correction, with monthly maintenance thereafter.