Mesotherapy in Prague

Polynucleotide (PDRN) injections at FaceExpert use salmon-derived DNA fragments to activate natural skin cell regeneration — stimulating collagen and elastin production, improving tissue hydration, and evening skin tone without adding volume. PDRN acts on A2A adenosine receptors on skin fibroblasts and keratinocytes, triggering cell proliferation and tissue remodelling pathways backed by peer-reviewed clinical evidence. At FaceExpert, the treatment is applied to two primary areas: the eye contour (targeting the delicate under-eye skin for dark circle improvement and periorbital crepiness reduction) and atrophic scar treatment (particularly boxcar and rolling acne scars). Single sessions are available at 7,900 Kč, with 2- and 3-session packages offering meaningful savings. Results are progressive, appearing over 4–8 weeks per session as new collagen matures. Polynucleotide biostimulation is increasingly preferred over traditional mesotherapy by patients who want deeper skin regeneration without volumisation or the foreign-body response of synthetic fillers.

Profhilo bioremodeling injection (2 ml) — high-concentration, thermally stabilised HA that hydrates deeply and biostimulates collagen and elastin across all skin layers without adding volume.

Profhilo bioremodeling injection (2 ml) — a hybrid HA injectable that simultaneously hydrates deeply and stimulates collagen and elastin production across all four skin layers, restoring skin quality and firmness without adding volume or changing facial shape.

Biorevitalization at Altos Klinika delivers non-cross-linked hyaluronic acid into the skin through a grid of micro-injections, deeply hydrating the dermis and stimulating its own regeneration. Treatments start at 7,900 Kč depending on area and product volume, with a more intensive dermarevitalization protocol available from 14,900 Kč.

Profhilo at Esthé Laser Clinic is an injectable skin remodelling treatment using one of the highest concentrations of pure, stabilised hyaluronic acid available — 64 mg in 2 ml, formulated without BDDE cross-linking agents. Unlike conventional dermal fillers that add volume in targeted zones, Profhilo spreads bio-revitalising hyaluronic acid across a wide skin area via a patented NAHYCO Hybrid Technology matrix. It stimulates four types of collagen and elastin simultaneously, producing a deep moisturisation and firmness effect that transforms skin quality from within rather than augmenting or reshaping it. The protocol uses five precisely mapped injection points per side of the face (the BAP technique), minimising discomfort while maximising diffusion. Two sessions four weeks apart constitute the primary course; results are visible from the second week and continue improving for up to three months. Ideal for anyone noticing a loss of skin elasticity, laxity on the jawline or neck, or general dullness.

Profhilo is a 97% hyaluronic acid bioremodeling injectable at Follow Clinic that stimulates elastin and collagen production throughout the skin, improving overall skin quality rather than targeting specific lines or adding volume. Two sessions administered 4 weeks apart are recommended at a combined cost of 15,000 Kč. Each 2 ml syringe contains 64 mg of HA and spreads up to 2 cm from each of the 5 BAP injection points, making it one of the most efficient skin boosters available. Results last 6–12 months and can be applied to the face, neck, chest, arms, hands, or knees.

PRP Plasmalifting at Petra Clinic uses the patient's own platelet-rich plasma to rejuvenate the skin through natural growth-factor stimulation. A small blood sample is drawn, centrifuged in the clinic's REGEN preparation system to concentrate platelets to three to five times physiological levels, then applied via multiple microinjections into the dermis of the face, neck or scalp. Platelets release a cocktail of growth factors — PDGF, TGF-β, VEGF, EGF — that activate resident fibroblasts, stimulate collagen and elastin synthesis, and improve tissue hydration. Because the treatment uses the patient's own biological material, the risk of allergic reaction is essentially zero. Two days without makeup is the typical post-treatment precaution; effects last up to twelve months.

Mesotherapy at Petra Clinic delivers a customised cocktail of active substances — vitamins, minerals, amino acids, hyaluronic acid, antioxidants and optionally the patient's own plasma — directly into the mid-dermis through multiple fine microinjections. By bypassing the skin barrier, mesotherapy concentrates bioactive molecules at the site where fibroblasts, keratinocytes and microvascular endothelium are actively metabolising, producing improvements in hydration, skin quality, brightness and fine-line reduction that topical application cannot replicate. The specific cocktail is tailored by the physician to the individual's skin condition, age and goals. A course of two to three sessions per year maintains and advances the benefit.

Salmon DNA Skin Rejuvenation at Petra Clinic uses Rejuran polynucleotide (PDRN) microinjections to activate the skin's repair machinery from within. PDRN — purified from salmon milt DNA — binds to adenosine receptors on fibroblasts, switching on collagen and elastin synthesis while simultaneously exerting anti-inflammatory effects that calm sensitised skin. Unlike hyaluronic acid fillers that add volume passively, PDRN triggers the skin's own regenerative pathways. The treatment is delivered as a series of precise microinjections into the mid-dermis of the face; results are visible after the first session and improve progressively. Minimal downtime — two days without makeup — and no allergy risk from salmon DNA (highly purified to remove proteins) make this a popular preventive and corrective treatment.

Desirial intimate area rejuvenation at S-thetics Beauty uses hyaluronic acid formulations specifically designed for the vulvovaginal region — Desirial® for hydration and rejuvenation, and Desirial® Plus for volume restoration and shape correction. Both products are part of the Vivacy/IBSA product family, the same manufacturer as the Stylage filler range used for facial treatments. MDDr. Darina Šanšašvili administers the injections in the clinic setting. The treatment addresses dryness, loss of elasticity, reduced volume, and aesthetic changes in the intimate area — conditions that commonly arise from hormonal changes after menopause, post-partum recovery, or the natural ageing process. Results include improved hydration, increased tissue suppleness and elasticity, enhanced intimate comfort, and aesthetic improvement of the vulvovaginal area. The effect of a single 2 ml session typically lasts six to twelve months.

Biostimulation at FaceExpert uses two of the most clinically established collagen-stimulating injectables — Radiesse (calcium hydroxyapatite) and Sculptra (poly-L-lactic acid) — to trigger the skin's own collagen and elastin production without adding unwanted bulk volume. Unlike HA fillers that restore lost volume directly, biostimulatory injectables stimulate the tissue to regenerate itself: Radiesse (13,900 Kč) uses calcium hydroxyapatite microspheres suspended in a gel that is progressively replaced by new collagen over 12–24 months; Sculptra (14,900 Kč) uses PLLA microparticles where clinical studies demonstrate a 66.5% increase in collagen production in the first month alone. The result is progressive improvement in skin firmness, texture, and lift rather than immediate volumisation. MUDr. Macko's international training credentials make her a high-proficiency injector of both products. Both treatments are fully natural in origin and carry no allergy risk.