Mesotherapy in Czechia

Micro-injection treatment with vitamins and hyaluronic acid.

Vitamin and hyaluronic acid microinjections for skin hydration and rejuvenation.

Skin rejuvenation through microinjections of vitamins and hyaluronic acid.

Superficial injection of non-crosslinked hyaluronic acid — alone or combined with vitamins, amino acids and trace ions — into the middle skin layer of the face, neck, décolletage or hands to restore deep moisture, improve skin elasticity and produce a hydrated, luminous complexion. Known as Mesolift when applied to the face and neck, this treatment delivers active ingredients directly to the dermis where topical products cannot penetrate, rebuilding the skin's hydration reservoir from within over a course of sessions. At Estetické centrum Praha MUDr. Renata Handlová uses ultra-thin 30–32 gauge needles and a specialist injector for consistent, uniform product distribution.

Polynucleotide therapy at RAJSKA Clinic uses DNA fragments derived from salmon (PDRN/PN) — Vitaran, Amella, or Plenhyage XL — to activate the skin's natural repair mechanisms at a cellular level. These polynucleotide molecules bind to adenosine receptors on skin cells, triggering growth factor release and accelerating tissue repair far beyond what HA or vitamin mixes can achieve. Particularly effective for the eye area (dark circles, fine lines), active acne, rosacea, post-acne scarring, and general skin laxity. The protocol is a three-session course and integrates seamlessly with VIVACE microneedle RF for enhanced results.

Biorevitalisation at Formositas covers one of Prague's widest menus of certified injectable revitalisers — from polynucleotide products (PLINEST) and amino-acid complexes (JALUPRO, SUNEKOS) to collagen stimulators (LINERASE) and succinate-HA combinations (HYALUAL Xela Rederm). Micro-injections deliver hyaluronic acid, amino acids, peptides and vitamins into the dermis to deeply hydrate the skin and regenerate collagen and elastin fibres, with the product chosen to match your skin's specific needs.

Skinbooster treatment at Perfect Visage delivers micro-deposits of hyaluronic acid or PDRN polynucleotides ('salmon DNA') into the dermis using the Vital Injector device, deeply hydrating the skin, improving elasticity and fine lines, and supporting regeneration. At 4,000 Kč per ampoule it is a popular skin-quality treatment for the face, neck and under-eye area.

Skin biostimulation at Berska Clinic involves minimally invasive micro-injections of biological agents — including polynucleotides, unlinked hyaluronic acid with amino acids, polylactic acid (PLA), polycaprolactone (PCL), and calcium hydroxyapatite — to stimulate the skin's own collagen and elastin production from within. Unlike traditional fillers which replace volume, biostimulants primarily trigger fibroblast activity, improving skin quality, elasticity, and hydration from the inside out. The agents are fully absorbed within approximately two years, leaving behind newly produced structural proteins rather than foreign material.

TrayLIFE plasma therapy is an autologous platelet-rich plasma (PRP) treatment using a branded single-use sterile kit system for blood collection, centrifuge processing, and platelet activation — distinct from generic PRP in its standardised preparation protocol. At Top Laser Olomouc, a small blood sample is drawn, processed in the clinic's centrifuge to concentrate growth-factor-rich plasma, and then injected via fine needle into the face, neck, or décolletage. Activated platelets release PDGF, TGF-β, VEGF, and other growth factors at the injection site, stimulating fibroblast activity, accelerating dermal collagen synthesis, and improving microcirculation. Because the treatment uses the patient's own blood, there is no risk of allergic reaction or foreign-body response. Results include visibly smoother skin texture, improved firmness, and enhanced radiance, with the recommended maintenance cycle of every six months.

Skin hydration and revitalisation delivered by the motorised multi-needle VITAL INJECTOR device, which deposits hyaluronic acid precisely and uniformly across the treatment zone with consistent injection depth and pressure. Unlike manual mesotherapy, the VITAL INJECTOR eliminates variation between injection points, reducing bruising and ensuring even product distribution. The treatment restores skin moisture reservoirs, improves skin quality and elasticity, and produces a luminous, refreshed complexion that manual hydration cannot replicate.

Injectable mesotherapy delivers a skin-booster blend of unlinked hyaluronic acid, amino acids, antioxidants, minerals and vitamin B6 into the upper layers of the skin through a series of fine micro-injections. Rather than adding volume or filling lines, it deeply rehydrates and improves tone and glow, softening fine lines on the face, neck and décolletage. At Estéea the treatment includes a gentle massage to distribute the product, and works best as a short course for cumulative results.

Biorevitalization at Follow Clinic delivers hyaluronic acid and supporting nutrients directly into the skin via micro-injections for intensive hydration and radiance at the cellular level. Treating the face alone is 4,200 Kč; combining face, neck, and décolletage in a single session is 8,900 Kč — covering the full extent of visible aging skin efficiently and cost-effectively. A series of 3 sessions spaced 2–4 weeks apart is recommended for lasting improvement, with maintenance sessions every 4–6 months. Suitable for all skin types. Minor redness at injection sites resolves within 24–48 hours.

Full-face PDRN-VITARAN biostimulation uses 2 ml of Korean polynucleotide solution micro-injected across the entire face to trigger collagen synthesis, improve micro-circulation and support tissue regeneration. The treatment delivers a higher dose than the eye-area-only protocol, providing whole-face skin quality improvement: reduced fine lines, improved elasticity, brighter complexion and more even skin tone. PDRN (polydeoxyribonucleotide) works at a cellular level by activating fibroblast regeneration pathways — distinct from hyaluronic acid hydration alone. At DermaClinique Písek, MUDr. Jůzlová, Ph.D. administers the treatment using precise micro-injection technique built on her hospital-level injectable medicine training.

Vital Injector is a device that delivers hyaluronic acid evenly into a precise depth of the skin, giving more uniform and economical hydration than freehand injection. At Dermaestet it is used as a skinbooster to smooth and tighten the skin, restore moisture and improve the look of fine wrinkles, tired or sun-stressed skin, with an immediate effect that lasts. Because dosing is automated and even, it suits the face, neck, décolletage and hands and gives a consistent, natural result.

A scalp mesotherapy treatment using INNO-TDS Hair Loss Control — a pharmaceutical-grade cocktail of hair growth factors, vitamins, and follicle-stimulating compounds — delivered via multiple microinjections directly into the scalp dermis. Unlike topical products that struggle to penetrate the scalp barrier, mesotherapy places active ingredients exactly where hair follicles are anchored. At Medianna Clinic, the procedure is performed by experienced medical staff, with the INNO-TDS range representing a clinically validated Spanish pharmaceutical protocol widely used across European dermatology practices for androgenic alopecia and diffuse hair thinning.

A nourishing scalp mesotherapy treatment using INNO-TDS Hair Vital — a pharmaceutical cocktail formulated for hair lacking density, shine, and vitality rather than active androgenic hair loss. While Hair Loss Control targets the hormonal and microcirculatory drivers of pattern baldness, Hair Vital is a comprehensive follicle-nutrition protocol for hair that is thinning due to stress, nutritional gaps, post-illness shedding, or environmental factors. At Medianna Clinic, both INNO-TDS formulations are available, allowing the physician to select or combine the appropriate protocol based on each patient's hair loss type.

Mesotherapy at I am clinic delivers vitamins, peptides, polynucleotides, and hyaluronic acid directly into the skin for deep hydration and revitalisation. The clinic offers it in two forms: Dermapen-assisted mesotherapy (4,500 Kč), where a motorised microneedling device drives the cocktail into the skin while triggering collagen-stimulating micro-injuries, and classic injectable mesotherapy from 6,500 Kč, including a bespoke 'Be Glamour' beauty cocktail tailored to your skin's needs. A dedicated eye-area protocol (5,500 Kč) targets fine lines, dark circles, and crepey under-eye skin with peptides and polynucleotides.

Renomé Clinic offers a family of injectable skin-quality treatments: classic mesotherapy delivering micro-doses of hyaluronic acid, vitamins, and amino acids into the superficial dermis for deep hydration; biorevitalization using highly purified HA or polynucleotide formulations to reactivate fibroblast activity; periorbital biostimulation targeted to the delicate eye area; and hair mesotherapy nourishing the scalp in thinning hair. All are physician- or dermatology-team administered, take 30–45 minutes, and require minimal downtime. The aim is skin that is measurably better hydrated, denser, and more luminous — rather than volumised or 'filled'.

Polynucleotide (PDRN) therapy at Estetika by Medfima uses purified salmon-derived DNA fragments injected into the dermis to promote deep cellular repair and skin regeneration. Unlike hyaluronic acid fillers that add volume, PDRN works by stimulating the skin's own repair machinery — activating fibroblasts, increasing collagen and elastin production, and promoting tissue oxygenation. The aesthetic team performs the treatment using fine needles or a cannula depending on the area, with anesthetic cream applied if needed. Separate protocols exist for the eye area and the full face, both at 4 500 Kč per session. Results are noticeable after the first session, with the full regenerative effect accumulating over a series.

Mesotherapy (mezolift) at EsteticUsti delivers a customised cocktail of vitamins, amino acids, and active compounds directly into the dermis via a series of micro-injections, bypassing the poor transdermal absorption that limits topical skincare. The technique was developed in France in the 1950s and refined over decades into the modern 'mezolift' protocols used today. By placing active ingredients precisely in the dermis — the skin layer responsible for structural integrity — mesotherapy achieves deep hydration, improved elasticity, and a brightness that topical products cannot replicate. At EsteticUsti, treatments target the face, neck, décolletage, and back of hands, with a separate scalp protocol for hair growth support.

Mesotherapy at ISCARE's dermatology department involves microinjections of a tailored blend of vitamins, hyaluronic acid, and active compounds into the middle layer of the skin to hydrate, brighten, and improve skin texture. At 4,600 Kč per session, the treatment is administered by trained dermatology staff and is typically performed as a course of 4–6 sessions for optimal facial rejuvenation. It targets dull skin, fine lines, and dehydration with minimal downtime.

Polynucleotide (PDRN) therapy involves injecting highly purified DNA fragments — derived from salmon sperm — into the dermis to trigger the skin's own repair and collagen synthesis pathways. At Skinderm Ostrava, topical anaesthetic is applied before fine needles deposit the PDRN solution at multiple intradermal points across the face, neck, or décolletage. The treatment stimulates fibroblasts to produce new collagen and elastin, and activates the A2A adenosine receptor pathway, which accelerates tissue repair and reduces inflammation. Results build cumulatively across 3–4 sessions.

Biorevitalisation at Impera Clinic injects a special form of hyaluronic acid beneath the skin to trigger the regenerative reactions that restore skin condition. Hyaluronic acid is a natural component of human skin with a strong water-binding capacity, which makes the skin firm and elastic. Rather than filling a specific wrinkle, biorevitalisation deeply hydrates and revitalises the skin across an area, improving overall texture, firmness, and radiance. It is well suited to skin that looks tired, dehydrated, or has lost its youthful glow.

Exosome therapy uses concentrated regenerative signalling particles to support skin repair, hydration and renewal. Exosomes are tiny messenger vesicles that carry growth factors and other signals that instruct skin cells to regenerate; applied to the skin — typically after a micro-channelling or energy treatment that helps them penetrate — they aim to improve radiance, hydration, texture and overall skin quality. At BB Health Clinic the AllStem exosome system is used on the face, offered as single applications or a six-session course. It suits adults wanting an advanced regenerative boost for tired, dull or early-ageing skin.