Type
Mesotherapy
Duration
45 min
What's included
4 deliverables in this treatment
- Skin diagnostics and consultation with aesthetic physician
- Anesthetic cream application (if required)
- PDRN/polynucleotide injections via fine needle or cannula
- Post-procedure aftercare instructions
Polynucleotide (PDRN) therapy at Estetika by Medfima uses purified salmon-derived DNA fragments injected into the dermis to promote deep cellular repair and skin regeneration. Unlike hyaluronic acid fillers that add volume, PDRN works by stimulating the skin's own repair machinery — activating fibroblasts, increasing collagen and elastin production, and promoting tissue oxygenation. The aesthetic team performs the treatment using fine needles or a cannula depending on the area, with anesthetic cream applied if needed. Separate protocols exist for the eye area and the full face, both at 4 500 Kč per session. Results are noticeable after the first session, with the full regenerative effect accumulating over a series.
About this treatment
Polynucleotide therapy — marketed under abbreviations such as PDRN (polydeoxyribonucleotide) or PN — has gained significant traction in European aesthetic medicine as a biostimulator rather than a filler. The active ingredient is a highly purified fraction of salmon sperm DNA, which after decades of research has been shown to bind purinergic receptors (specifically A2A receptors) on fibroblast cells. This binding triggers a cascade of regenerative…
At Estetika by Medfima in Pardubice, MUDr. Holohlavská and colleagues perform polynucleotide injections as a standalone regenerative protocol or in combination with biorevitalisation or HA fillers for a more comprehensive result. The clinic's two dedicated protocols — one for the delicate periorbital area (around the eye), one for the face excluding eyes — allow precise dosing calibrated to the tissue depth and sensitivity of each zone. An anesthetic…
The recommended starting course is 2–4 sessions spaced 2–4 weeks apart, determined by the physician during the initial consultation based on the client's skin condition and treatment goals. Clients with significant sun damage, post-acne scarring, or pronounced fine lines typically benefit from a full four-session course, while those seeking preventive or maintenance care may see excellent results from two. Annual top-up treatments of 1–2 sessions are…
Good to know
- Active ingredient
- PDRN (salmon DNA fragments)
- Protocols
- Eye area / Face (separate pricing)
- Sessions
- 2–4 sessions, 2–4 weeks apart
- Mechanism
- Fibroblast stimulation + collagen/elastin synthesis
- First results
- Noticeable after session 1
Who is this for?
Skin laxity without significant volume loss, periorbital crepiness, dull or tired complexion, post-acne scarring, preventive skin regeneration from age 30+
Preparation required
Avoid blood-thinning medications and alcohol 24 hours before. If you have a fish or seafood allergy, inform the clinic before booking — PDRN is salmon-derived. Come with clean skin free of makeup.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
Clinical team
Estetika by Medfima is staffed entirely by licensed physicians. MUDr. Monika Motyčková Ph.D. is a general practitioner with specialist qualifications in obesity medicine and internal medicine, performing wrinkle reduction and English-language consultations. MUDr. Sabina Holohlavská specialises in aesthetic medicine and performs mesotherapy, HA fillers, lip augmentation, non-surgical lifting, and polynucleotide…
Clinic-reported credentials
Languages: Czech, English, German, Italian, French, Hungarian
What clients say
"{"text":"The doctor is experienced and explains everything so I understand it. The staff is kind and helpful.","author":"Karel Jánský","source":"Medfima website"}"
"{"text":"Both the doctor and nurse were pleasant and treated me as an equal. What surprised me was their extraordinary attention to my needs.","author":"Natálie Fidlerová","source":"Medfima website"}"
Treatment highlights
- Skin diagnostics and consultation with aesthetic physician
- Anesthetic cream application (if required)
+2 more items in What's included
4 500 Kč per session (eye area or face excl. eyes). Recommended course of 2–4 sessions at 2–4 week intervals. Annual maintenance of 1–2 sessions.