Type
Mesotherapy
Duration
45 min
What's included
4 deliverables in this treatment
- Skin assessment and selection of the appropriate biostimulant agent(s)
- Micro-injection treatment session using polynucleotides, unlinked HA, PLA, PCL, or CaHA as indicated
- Post-treatment aftercare instructions
- Course planning and treatment interval recommendation
Skin biostimulation at Berska Clinic involves minimally invasive micro-injections of biological agents — including polynucleotides, unlinked hyaluronic acid with amino acids, polylactic acid (PLA), polycaprolactone (PCL), and calcium hydroxyapatite — to stimulate the skin's own collagen and elastin production from within. Unlike traditional fillers which replace volume, biostimulants primarily trigger fibroblast activity, improving skin quality, elasticity, and hydration from the inside out. The agents are fully absorbed within approximately two years, leaving behind newly produced structural proteins rather than foreign material.
About this treatment
Skin biostimulation represents a fundamental shift in the philosophy of aesthetic injection therapy: rather than replacing what is lost (volume, contour) with a filler material, the goal is to reactivate the skin's own regenerative biology. MUDr. Šárka Běrská uses a range of injectable biostimulants, selecting the appropriate agent or combination based on the individual patient's skin condition, age, and treatment goals.
Polynucleotides (PDRN/PN) are fragments of purified DNA extracted from fish sperm or plant sources. They work through receptor-mediated tissue repair: polynucleotides activate A2A adenosine receptors in fibroblasts, directly stimulating the production of collagen, elastin, and extracellular matrix components. They also have anti-inflammatory and antioxidant effects at the cellular level, making them useful for dull, sun-damaged, and post-acne skin.…
Unlinked (free) hyaluronic acid with amino acids acts as a deep hydration depot in the dermis. Unlike cross-linked HA fillers (which are designed for structural support), unlinked HA spreads within the interstitial space, attracting and retaining water molecules and replenishing the hydration gradient that diminishes with age. It is typically combined with amino acids and vitamins (a mesotherapy cocktail) for enhanced skin nourishment. Products such as…
Good to know
- Agents
- Polynucleotides, unlinked HA, PLA, PCL, CaHA
- Mechanism
- Fibroblast activation and collagen stimulation
- Bioresorbable
- Fully absorbed within ~2 years
- Downtime
- Minimal — redness 24–48h
- Result timeline
- Progressive improvement over 4–8 weeks
Who is this for?
Dry, dehydrated, ageing or dull skin, preventive anti-aging, post-acne skin quality, patients preferring regenerative over volume-replacement approach
Preparation required
Avoid blood-thinning supplements for 2 days before treatment. Arrive with clean skin. Inform the doctor of any allergies or prior injectable treatments.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
40 clinic reviews
From independent platforms
Clinical team
The clinic is run entirely by MUDr. Šárka Běrská, a certified general practitioner (atestovaná praktická lékařka) with an additional specialisation in aesthetic and anti-aging medicine and cosmetology. She has practiced aesthetic medicine since 2008 — 18 years of experience — and holds Czech Medical Chamber (ČLK) licence 5135549166. She is an active member of the Society of Aesthetic and Laser Medicine (SELM ČLS…
Clinic-reported credentials
Languages: Czech
What clients say
"Paní doktorka je velká profesionálka, všechno mi srozumitelně vysvětlila. (The doctor is a true professional — she explained everything clearly to me.) — Estheticon.cz verified patient"
"100% recommend. I have been visiting MUDr. Běrská for years. She always finds the right approach and the results speak for themselves. — Estheticon.cz verified patient"
Treatment highlights
- Skin assessment and selection of the appropriate biostimulant agent(s)
- Micro-injection treatment session using polynucleotides, unlinked HA, PLA, PCL, or CaHA as indicated
+2 more items in What's included
From 4,000 Kč per session (biostimulation/plasma therapy category, Estheticon-sourced). Mesotherapy range 3,000–6,000 Kč per session. Price varies with the specific biostimulant used (polynucleotides, PLA, PCL, unlinked HA) and the number of areas treated. A course of two to four sessions is typically recommended; exact pricing and course structure are confirmed at the free consultation.