Ozone IV + Ultraviolet Blood Irradiation (UVB)

WholeHealth Chicago's combined Ozone IV plus Ultraviolet Blood Irradiation (UVB) session pairs ozone autotransfusion with exposure of the patient's blood to ultraviolet light before re-infusion. UV blood irradiation — also called photobiomodulation or biophotonic therapy — has been used in integrative medicine as a complement to ozone therapy. The combined session is priced at $240 and is offered as the premium ozone protocol at the Lincoln Park clinic. Sessions run approximately 45 to 60 minutes.

The Ozone IV plus Ultraviolet Blood Irradiation (UVB) protocol at WholeHealth Chicago combines two blood-based therapeutic modalities in a single 45 to 60 minute session. In the combined protocol, the patient's blood is drawn, ozonated with medical-grade ozone-oxygen mixture at a calibrated concentration, and then passed through a UV irradiation cuvette — a transparent chamber through which the blood flows and is exposed to ultraviolet light — before being returned to the patient intravenously. Ultraviolet blood irradiation (UBI), also known as photobiomodulation or biophotonic therapy, has a decades-long history in both conventional and integrative medicine. Early research in the mid-twentieth century investigated UBI for bacterial infections before the antibiotic era. Contemporary integrative medicine practitioners propose that ultraviolet irradiation of blood may modulate immune cell activity, reduce certain pathogen loads, and complement the immune-modulating effects of ozone therapy. The ultraviolet wavelengths most commonly used in blood irradiation are in the UVB range (280–320 nm) or the UVC range (below 280 nm), depending on the equipment. At WholeHealth Chicago, the combined ozone + UVB protocol is positioned as the clinic's most comprehensive blood-based infusion therapy, priced at $240 per session versus $140 for ozone alone. The addition of UVB to the ozone protocol is intended to combine the oxidative signalling effects of ozone with the light-mediated immune effects of UV irradiation in a single treatment. The clinic has offered this combination protocol since at least 2020, documented in its published blog content. A course of at least 10 sessions is typically recommended to complete an ozone-UVB treatment cycle. Membership plan holders receive discounted session pricing.