EBOO / 10-Pass Ozone Therapy

Extracorporeal Blood Ozonation and Oxygenation (EBOO) — also known as 10-pass ozone — circulates blood through an external circuit where it is treated with ozone before being returned to the body. More ozone exposure per session than standard major autohemotherapy. Associated with enhanced antioxidant response and immune modulation. Sessions run approximately 60–90 minutes under physician supervision at Patients Medical, New York City.

EBOO (Extracorporeal Blood Ozonation and Oxygenation), sometimes referred to as 10-pass ozone therapy due to its historical delivery method, represents the most advanced and high-dose systemic ozone therapy available at Patients Medical. Unlike standard major autohemotherapy (MAH), which treats a fixed volume of blood in a single pass, EBOO uses a closed-circuit extracorporeal system with a specialized ozone-resistant dialyzer membrane. Blood is continuously withdrawn from the patient, passed through the treatment circuit where it contacts ozone-oxygen gas at precisely controlled concentrations across a large surface area membrane, and returned simultaneously — allowing continuous treatment of the bloodstream at a substantially higher total ozone dose per session than single-pass MAH can achieve. The continuous-flow closed system also maintains sterility throughout the process, a key advantage over some earlier multi-pass protocols. The higher ozone dose associated with EBOO is thought to produce a more pronounced activation of the Nrf2 pathway, a stronger lipid peroxidation secondary messenger signal, and potentially greater upregulation of antioxidant enzymes including superoxide dismutase, catalase, and glutathione peroxidase compared to standard MAH. EBOO is typically positioned at the higher-intensity end of ozone therapy protocols at integrative clinics and is often recommended for patients who have not responded to standard ozone MAH, those with complex chronic conditions, or as an intensive course for specific functional medicine indications. Sessions run approximately 60–90 minutes under continuous physician or supervised nursing oversight. Patients Medical's blog lists NYC market rates for EBOO at approximately $1,000 per session, making it one of the higher-cost individual infusion modalities at the practice. All EBOO therapy is by physician prescription and individual assessment.