Kidney Function Panel

IFCOR's Kidney Function Panel tests ten markers covering glomerular filtration, electrolyte balance, tubular function, and urine sediment to give a complete picture of kidney health in a single fasting collection. The CKD-EPI equation — calculated from creatinine, age, and sex — provides an estimated glomerular filtration rate (eGFR) that is the internationally standard metric for chronic kidney disease staging. Uric acid flags gout risk and urate nephropathy. Urinalysis with sediment detects protein loss, blood, and infection indicators that blood tests alone cannot reveal. At 300 Kč, this targeted panel is accessible for regular monitoring in hypertensive, diabetic, or at-risk patients.

Chronic kidney disease (CKD) affects approximately 10–15% of adults worldwide and is frequently asymptomatic until GFR falls below 30 mL/min/1.73m² — by which point 70% of nephron mass has been lost. Early detection through regular monitoring is the cornerstone of CKD management and a key intervention point for slowing progression. IFCOR's Kidney Function Panel captures all clinically relevant early-detection markers in a single affordable panel. Urea is a waste product of protein metabolism excreted by the kidneys; elevated urea with normal creatinine indicates pre-renal causes (dehydration, high protein intake), while both rising together suggests reduced glomerular filtration. Creatinine is produced at a relatively constant rate from skeletal muscle creatine metabolism and filtered freely by the glomerulus without reabsorption — making it the standard filtration marker, though it is affected by muscle mass. The CKD-EPI equation uses serum creatinine, age, and sex to calculate eGFR, providing a normalised filtration rate that corrects for the muscle-mass confound and enables staging according to KDIGO guidelines (G1–G5). Sodium and potassium are the primary regulators of fluid balance and membrane potential; their ratio and absolute values reflect both renal tubular function and systemic homeostasis. Chloride balances the anion gap with bicarbonate in acid-base assessment. Calcium and phosphate are tightly regulated by the kidney in partnership with parathyroid hormone and vitamin D; their derangement in CKD (hyperphosphataemia, hypocalcaemia) drives renal osteodystrophy and cardiovascular calcification. Uric acid is the end product of purine metabolism; hyperuricaemia is both a marker and a potential cause of CKD progression. Urinalysis plus sediment adds dimensions that blood tests cannot capture: proteinuria (the most sensitive early marker of glomerular damage), haematuria (blood in urine, which may indicate glomerulonephritis, urological malignancy, or infection), nitrites and leukocyte esterase (urinary tract infection markers), and cast morphology (distinguishes nephritic from nephrotic presentations).