Belkyra — Non-Surgical Double Chin Reduction

Submental fat — the localised fat deposit that creates the appearance of a double chin — is often resistant to diet and exercise because it is largely driven by genetics and anatomy rather than overall adiposity. Belkyra is the first injectable specifically approved by both the FDA and EMA for the non-surgical reduction of moderate to severe submental fat in adults.

The active ingredient, deoxycholic acid, is a secondary bile acid that the body uses naturally in the digestive system to break down and absorb dietary fat. When synthesised as a pharmaceutical and injected into adipose tissue, it acts as a cytolytic agent: it disrupts the phospholipid bilayer of the fat cell membrane, causing the cells to lyse (rupture). The lipids are released into the interstitial space and cleared via the lymphatic and vascular…

At AV Aesthetics, each Belkyra session follows a careful protocol. Detailed photographic documentation is taken before injection. The submental area is cleaned with antiseptic, a local anaesthetic is administered, and a cooling pad is applied before and after the injection grid. MUDr. Vochtová injects Belkyra in a pre-marked grid pattern across the submental fat zone, targeting the fat layer precisely while avoiding the overlying dermis and underlying…