Radiesse — Collagen Stimulation (1.5 ml)

Radiesse calcium hydroxyapatite biostimulator and filler (1.5 ml) for mid-face volumisation, jawline definition, hand rejuvenation, or collagen stimulation with immediate plus progressive long-term results.

Radiesse is unique among injectable aesthetic products in that it serves two distinct functions simultaneously: as an immediate filler (the calcium hydroxyapatite microspheres in a carboxymethylcellulose carrier provide instant volumisation) and as a long-term biostimulator (the microspheres trigger a foreign-body-induced fibroblast response that generates new collagen in the treated area, which persists after the filler itself has been absorbed). This dual mechanism means Radiesse produces both an immediate visible result and a progressive structural benefit that extends its clinical effect beyond the typical HA filler timeline. At Upgrade Clinic, 1.5 ml of Radiesse is priced at 10,000 CZK (approximately 400 EUR), with 3 ml at 18,000 CZK and 4.5 ml at 26,000 CZK. This pricing reflects the premium positioning of Radiesse compared to standard HA fillers — the biostimulatory mechanism justifies the higher cost per millilitre, as the treatment provides more durable structural improvement over 12 to 18+ months. Common uses at Upgrade Clinic include mid-face volumisation to restore the submalar hollow that develops with age-related fat pad descent, jawline definition to restore the mandibular angle and improve the jaw-to-neck ratio, and hand rejuvenation to restore dorsal hand volume that thins with age, making tendons and veins more prominent. Radiesse can also be diluted (hyperdiluted Radiesse) and injected across a broad surface area for general skin quality biostimulation — a technique increasingly popular for neck and décolleté rejuvenation. Because calcium hydroxyapatite is an inorganic compound rather than a biological polymer, Radiesse cannot be dissolved with hyaluronidase (unlike HA fillers). The clinic discusses this non-reversibility with patients before treatment, ensuring it is used in appropriate anatomical zones where reversal is not typically required.