Food Intolerance Tests (Lactose, Gluten, Fructose, Histamine)

A suite of food intolerance blood tests covering lactose intolerance (genetic and/or serology), gluten sensitivity (serology), fructose intolerance (genetic), celiac disease antibodies (anti-TTG IgA), histamine intolerance (DAO enzyme level), and celiac genetic predisposition. Available individually or as bundles through cz.unilabs.online, collected at any Prague Unilabs point. Each test includes specialist physician interpretation from uLékaře.cz in the base price. The 3-in-1 bundle (fructose + lactose + celiac genetic) is available at 3,613 Kč. Rated 4.86/5 from 63 reviews.

The Unilabs food intolerance test suite addresses the most common dietary intolerances that affect digestive comfort, energy levels, and nutritional status in Central European adults. Unlike food allergy (which involves IgE-mediated immune reactions and can cause anaphylaxis), food intolerances are metabolic or enzymatic in nature — the body lacks the capacity to digest or process certain food components, leading to gut symptoms, bloating, diarrhoea, and systemic effects that develop hours after eating and are easy to misattribute. Lactose intolerance is caused by reduced expression of the lactase enzyme (which cleaves lactose into glucose and galactose for absorption) in adulthood — a genetically determined trait present in approximately 40–50% of European adults and over 70% of global adults. Two testing approaches are offered: genetic testing of the MCM6 gene variant (C13910T) that determines persistent lactase expression, and serological testing. Genetic testing is definitive — it confirms the innate capacity for lactose digestion regardless of current diet or gut microbiome state. Fructose intolerance (hereditary fructose intolerance, HFI) caused by aldolase B deficiency is a rare condition, but fructose malabsorption (a separate, common condition of impaired fructose absorption in the small intestine) is far more prevalent. The genetic test available through Unilabs screens for the hereditary metabolic disorder; patients with functional fructose malabsorption may require a hydrogen breath test for definitive diagnosis. Histamine intolerance is evaluated through DAO (diamine oxidase) enzyme activity. DAO is the primary enzyme responsible for degrading histamine in the gut after ingestion of histamine-rich foods (fermented foods, alcohol, aged cheeses, processed meats, tomatoes). Reduced DAO activity leads to histamine accumulation and symptoms that mimic allergy: flushing, headache, itching, urticaria, nasal congestion, and digestive complaints. Low serum DAO activity strongly suggests histamine intolerance. Gluten serology (anti-TTG IgA and/or anti-deamidated gliadin peptide IgG) screens for the autoimmune response to gluten that characterises celiac disease. A positive result warrants gastroenterological referral for duodenal biopsy confirmation before starting a lifelong gluten-free diet. All food intolerance tests include specialist interpretation in the price — a practical addition given the complexity of applying these results to dietary decisions. The 3-in-1 bundle combining fructose, lactose, and celiac genetic testing provides comprehensive coverage of the most common dietary intolerances in a cost-effective package.