Salmon DNA Polynucleotide Therapy

Polynucleotide therapy — popularly known as 'salmon DNA' — is one of the newest regenerative injectables in aesthetic medicine, and TobePrime Clinic offers it for the full face, the delicate eye area, and scar regeneration. Purified polynucleotide fragments derived from salmon DNA may support tissue repair, hydration, and elasticity by creating a regenerative environment in the dermis, rather than filling or freezing it. Courses of two sessions are the standard protocol for face and eye treatments.

Polynucleotides (PN/PDRN) are chains of purified DNA fragments, typically sourced from salmon, with high biocompatibility in human tissue. Injected into the dermis, they are associated with improved fibroblast activity, tissue oxygenation, hydration, and elasticity — a regenerative rather than volumising mechanism. This has made 'salmon DNA' one of the fastest-growing categories in European aesthetic medicine, particularly for zones where conventional fillers are risky or look unnatural, such as the under-eye area. TobePrime Clinic offers three published protocols. **Full-face regeneration** (14,000 Kč for 2 treatments) delivers intensive regeneration across the whole face — improving skin density, fine lines, and overall quality. **Eye-area treatment** (10,000 Kč for 2 treatments) targets the thinnest, most delicate skin on the face, where polynucleotides can brighten, firm, and smooth crepiness with a low risk profile. **Scar therapy** (5,000 Kč per session) uses the tissue-regenerative properties of polynucleotides to support healing and remodelling of scars. Sessions take 20–25 minutes and involve a series of micro-injections after topical numbing. Mild swelling or papules settle within 24–48 hours. Face and eye protocols are delivered as two sessions spaced several weeks apart, with skin quality improving progressively over the following 1–3 months. Results are commonly maintained with a top-up session every 6–9 months.