Genetic Testing — Genomic Health Panel

Comprehensive genomic health testing at Thomson Wellth Clinic covering cancer predisposition, pharmacogenomics, and nutrigenomics to enable personalised preventive health and lifestyle planning.

Thomson Medical Centre, through its Thomson Wellth Clinic at Novena, offers a suite of genomic and genetic testing programmes designed to give patients actionable insights into their inherited health risks, medication responses, and nutritional needs. Genetic testing at Thomson Wellth is positioned within a lifestyle medicine framework: results are not delivered in isolation but as part of a structured wellness consultation where a physician interprets findings in the context of the patient's health history, current biomarkers, and personal goals. The cancer predisposition panel assesses inherited variants in high-penetrance genes including BRCA1, BRCA2, PALB2, ATM, CHEK2, MLH1, MSH2, MSH6, PMS2, and APC, providing lifetime risk estimates for breast, ovarian, colorectal, and pancreatic cancers. Pharmacogenomics testing analyses variants in cytochrome P450 enzymes (CYP2D6, CYP2C19, CYP2C9, CYP3A4/5) and drug transporter genes affecting the metabolism of common medications including antidepressants, antihypertensives, statins, anticoagulants, and analgesics — enabling personalised prescribing and reducing adverse drug reactions. Nutrigenomics profiling examines gene variants affecting vitamin D metabolism (VDR), folate processing (MTHFR), omega-3 utilisation, caffeine metabolism (CYP1A2), lactose and gluten sensitivity, and carbohydrate/fat response, providing dietary personalisation beyond standard nutritional advice. A comprehensive cardiovascular genetics module covers variants in LDLR, PCSK9, and APOE for familial hypercholesterolaemia and Alzheimer's risk. All tests are performed from a saliva or blood sample and processed through accredited genomics laboratories. A pre-test genetic counselling session is included, and results consultation with a physician ensures that findings are contextualised within a clear preventive action plan.