NAD+ Regular 500mg

A three-hour intravenous infusion of 500 milligrams of NAD+ (nicotinamide adenine dinucleotide). This high-dose standalone protocol delivers double the standard 250mg dose, providing a more intensive cellular support session for clients who have established tolerance through previous NAD+ infusions and want maximum benefit from a single-bag protocol.

The NAD+ Regular 500mg at Toronto Functional Medicine Centre delivers the higher 500mg dose of NAD+ as a standalone single-bag infusion over approximately three hours. This protocol is designed for clients who have already completed at least one 250mg session and want to intensify their NAD+ therapy without adding the cofactor and glutathione bags included in the Combo protocol. The 500mg dose doubles the amount of NAD+ delivered compared to the Regular 250mg, providing a more substantial increase in circulating NAD+ levels per session. Research suggests that higher doses may produce more pronounced effects on mitochondrial function, sirtuin activation, and cognitive clarity, though individual responses vary. Some clients report more noticeable improvements in energy, mental focus, and sleep quality with the 500mg dose compared to 250mg. The three-hour infusion time is necessary because the drip rate must remain controlled even at the higher dose. Administering 500mg too quickly would amplify the temporary side effects — flushing, chest sensation, nausea — that the controlled rate is designed to minimise. The clinical team at TFMC monitors throughout and maintains a rate that balances therapeutic delivery with client comfort. The standalone 500mg Regular differs from the 500mg Combo in cost and composition. The Regular delivers NAD+ alone at a lower price point, while the Combo adds the cofactor priming bag and glutathione finishing bag for a more comprehensive but more expensive session. The choice between them often comes down to whether the client already supplements cofactors orally and whether they prioritise cost or comprehensiveness. Dr. Caversan typically recommends the 500mg Regular for established NAD+ clients who are transitioning from the 250mg dose and want to increase intensity without the full Combo protocol. It can serve as either a loading dose during an initial treatment phase or as a periodic intensive session within a longer-term maintenance schedule.