NAD+ Combo 500mg

A comprehensive three-hour NAD+ infusion protocol comprising three sequential IV bags: the first delivers a foundation of vitamins, minerals, and amino acids; the second provides 500 milligrams of NAD+; and the third finishes with glutathione for antioxidant support. This multi-bag approach ensures cellular machinery is primed with cofactors before NAD+ delivery and protected from oxidative stress afterward.

The NAD+ Combo 500mg is Toronto Functional Medicine Centre's flagship infusion protocol, reflecting Dr. Amauri Caversan's functional medicine approach of supporting cellular health through complementary pathways rather than relying on a single intervention. The session spans approximately three hours and comprises three distinct IV bags administered sequentially. The first bag delivers a carefully formulated blend of vitamins, minerals, and amino acids — the cofactors and substrates that cellular enzymes require to function optimally. This includes B-complex vitamins that serve as cofactors in the mitochondrial electron transport chain, magnesium for enzymatic support, and amino acids that participate in neurotransmitter synthesis and protein turnover. By delivering these foundational nutrients first, the protocol ensures that the cellular machinery is primed and ready to utilise the NAD+ that follows. The second bag contains 500 milligrams of NAD+ (nicotinamide adenine dinucleotide), infused at a controlled rate that balances therapeutic delivery with client comfort. NAD+ is a coenzyme essential for over 500 enzymatic reactions in the body, including the sirtuins (involved in DNA repair and gene regulation), PARP enzymes (involved in DNA damage response), and CD38 (involved in immune signalling and calcium regulation). The 500mg dose represents the higher end of clinical NAD+ protocols and is suited for clients seeking maximum cellular support. The third bag delivers glutathione, the body's primary intracellular antioxidant. The rationale for sequencing glutathione after NAD+ is twofold: NAD+ metabolism generates some reactive oxygen species as a byproduct of increased mitochondrial activity, and glutathione neutralises these oxidants, protecting the cellular benefits achieved by the preceding infusions. Glutathione also supports Phase II liver detoxification, helping the body process and excrete metabolic waste products generated by the increased cellular activity. This three-bag protocol is distinctive in the Toronto market. Most IV therapy clinics offer NAD+ as a standalone infusion. TFMC's approach addresses the functional medicine observation that NAD+ supplementation is most effective when the surrounding metabolic environment is optimised — cofactors are present, antioxidant defences are strong, and the enzymatic pathways that utilise NAD+ are functioning well. The three-hour session is conducted in the clinic's IV lounge, with clinical monitoring throughout. Clients are encouraged to bring entertainment for the duration — a book, laptop, or headphones. The controlled drip rate minimises the flushing, chest tightness, and nausea that can occur with rapid NAD+ delivery.