Type
Blood Testing
Biomarkers
11
Duration
10 min
Measurement of 25-hydroxyvitamin D (calcidiol), the primary circulating storage form of vitamin D. This marker reflects total vitamin D status from both dietary intake and skin synthesis, making it the gold standard for assessing deficiency. Vitamin D plays critical roles in calcium metabolism, bone health, immune function, and mood regulation.
Vitamin D deficiency is endemic in central Europe, with studies showing that 50 to 60 percent of the German population falls below the optimal threshold of 30 ng/mL, particularly during the winter months when UVB radiation is insufficient for cutaneous synthesis at Munich's latitude. The 25-hydroxyvitamin D test captures total body stores by measuring the liver's conversion product of both dietary and sun-derived vitamin D. Beyond its well-established role in calcium absorption and bone mineralisation, vitamin D functions as a secosteroid hormone with receptors in virtually every tissue. Adequate levels support innate and adaptive immune responses, modulate inflammatory pathways, contribute to insulin sensitivity, and influence serotonin production. Deficiency has been associated with increased susceptibility to respiratory infections, autoimmune conditions, cardiovascular risk, and depressive symptoms. SYNLAB München Zentrum measures 25-OH vitamin D using liquid chromatography–tandem mass spectrometry or competitive immunoassay, depending on clinical context. No fasting is required. Results are typically available within one to three working days. For patients found to be deficient, supplementation dosing should be guided by a physician based on the severity of the deficit and individual factors such as body weight and absorption capacity.
Key Details
- Biomarkers
- 1
- Results
- 1-3 working days
- Fasting
- Not required
Who Is This For?
Winter screening, fatigue investigation, bone health assessment, immune optimisation, supplementation monitoring
What's Included
Panel Categories
Biomarkers Tested
11A trace mineral essential for iron metabolism, connective tissue formation, and antioxidant defense. The copper/zinc ratio is an emerging marker of inflammation and oxidative stress. Both deficiency and excess can cause problems.
Essential for DNA synthesis, cell division, and red blood cell formation. Folate deficiency causes megaloblastic anemia and, during pregnancy, increases the risk of neural tube defects. Works closely with vitamin B12.
Involved in over 300 enzymatic reactions including energy production, muscle function, and nerve signaling. Magnesium deficiency is common and associated with muscle cramps, anxiety, insomnia, and increased cardiovascular risk.
A trace mineral crucial for thyroid hormone metabolism, antioxidant defense (via selenoproteins), and immune function. Selenium deficiency can impair thyroid function and increase susceptibility to viral infections.
A fat-soluble vitamin essential for vision, immune function, skin health, and cell growth. Both deficiency and excess can cause health problems. Levels are tightly regulated by the liver.
Essential for nerve function, DNA synthesis, and red blood cell formation. B12 deficiency can cause anemia, neuropathy, fatigue, and cognitive impairment. Common in vegans, vegetarians, older adults, and those taking metformin or acid-reducing medications.
A powerful water-soluble antioxidant essential for collagen synthesis, immune function, and iron absorption. Vitamin C deficiency causes scurvy. It also supports wound healing and protects against oxidative stress.
The best indicator of overall vitamin D status. Vitamin D is essential for calcium absorption, bone health, immune function, and mood regulation. Deficiency is extremely common, especially in northern latitudes, and linked to increased disease risk.
A fat-soluble antioxidant that protects cell membranes from oxidative damage. Vitamin E works synergistically with vitamin C and selenium. Deficiency is rare but can cause nerve and muscle damage.
Essential for blood clotting and bone metabolism. Vitamin K activates proteins needed for blood coagulation and calcium regulation in bones. Deficiency increases bleeding risk and may contribute to osteoporosis.
An essential trace mineral involved in immune function, wound healing, DNA synthesis, and testosterone production. Zinc deficiency impairs immune response, delays wound healing, and can cause hair loss and taste changes.