Type
Blood Testing
Biomarkers
11
Duration
10 min
A two-marker panel measuring serum vitamin B12 (cobalamin) and folate (vitamin B9). Both vitamins are essential for DNA synthesis, red blood cell formation, and neurological function. Deficiency in either can cause megaloblastic anaemia, cognitive impairment, and peripheral neuropathy. This combination is particularly relevant for vegetarians, vegans, older adults, and patients on metformin or proton pump inhibitors.
Vitamin B12 and folate work in tandem within the methylation cycle — a metabolic pathway that underpins DNA repair, neurotransmitter synthesis, and homocysteine clearance. When either vitamin is insufficient, the cycle stalls, leading to elevated homocysteine (an independent cardiovascular risk factor), impaired red blood cell maturation, and progressive neurological damage that may be irreversible if caught late. B12 deficiency develops insidiously because the liver stores enough to mask inadequate intake for two to five years. By the time symptoms appear — numbness, balance problems, cognitive fog, mood changes — significant nerve damage may already exist. Groups at elevated risk include vegans and strict vegetarians (B12 is found almost exclusively in animal products), adults over 60 (reduced intrinsic factor and gastric acid production), patients on proton pump inhibitors (impaired B12 absorption), and those taking metformin (which interferes with B12 uptake in the ileum). Folate deficiency presents more rapidly, typically within months of inadequate intake, and is especially critical during early pregnancy when it dramatically increases the risk of neural tube defects. At SYNLAB München Zentrum, both markers are measured from a single venous blood draw. No fasting is required. Results are typically available within one to two working days.
Key Details
- Biomarkers
- 2
- Results
- 1-2 working days
- Fasting
- Not required
Who Is This For?
Vegetarians and vegans, older adults, metformin or PPI users, fatigue investigation, pre-pregnancy planning
What's Included
Panel Categories
Biomarkers Tested
11A trace mineral essential for iron metabolism, connective tissue formation, and antioxidant defense. The copper/zinc ratio is an emerging marker of inflammation and oxidative stress. Both deficiency and excess can cause problems.
Essential for DNA synthesis, cell division, and red blood cell formation. Folate deficiency causes megaloblastic anemia and, during pregnancy, increases the risk of neural tube defects. Works closely with vitamin B12.
Involved in over 300 enzymatic reactions including energy production, muscle function, and nerve signaling. Magnesium deficiency is common and associated with muscle cramps, anxiety, insomnia, and increased cardiovascular risk.
A trace mineral crucial for thyroid hormone metabolism, antioxidant defense (via selenoproteins), and immune function. Selenium deficiency can impair thyroid function and increase susceptibility to viral infections.
A fat-soluble vitamin essential for vision, immune function, skin health, and cell growth. Both deficiency and excess can cause health problems. Levels are tightly regulated by the liver.
Essential for nerve function, DNA synthesis, and red blood cell formation. B12 deficiency can cause anemia, neuropathy, fatigue, and cognitive impairment. Common in vegans, vegetarians, older adults, and those taking metformin or acid-reducing medications.
A powerful water-soluble antioxidant essential for collagen synthesis, immune function, and iron absorption. Vitamin C deficiency causes scurvy. It also supports wound healing and protects against oxidative stress.
The best indicator of overall vitamin D status. Vitamin D is essential for calcium absorption, bone health, immune function, and mood regulation. Deficiency is extremely common, especially in northern latitudes, and linked to increased disease risk.
A fat-soluble antioxidant that protects cell membranes from oxidative damage. Vitamin E works synergistically with vitamin C and selenium. Deficiency is rare but can cause nerve and muscle damage.
Essential for blood clotting and bone metabolism. Vitamin K activates proteins needed for blood coagulation and calcium regulation in bones. Deficiency increases bleeding risk and may contribute to osteoporosis.
An essential trace mineral involved in immune function, wound healing, DNA synthesis, and testosterone production. Zinc deficiency impairs immune response, delays wound healing, and can cause hair loss and taste changes.