Vyšetření jater — Liver Panel

Focused liver function assessment at SYNLAB Brno measuring ALT, AST, and GGT — the three key hepatic enzymes used in routine clinical practice. At 101 CZK (~4 EUR), one of the most affordable liver screens in Central Europe — ideal for routine monitoring or medication safety checks.

This three-enzyme panel provides the core liver function assessment used globally in clinical practice. ALT (alanine aminotransferase) is the most hepatocyte-specific of the three markers — it is predominantly found in liver cells and released into the bloodstream upon cellular injury. Mild ALT elevation (1-3 times the upper limit of normal) is among the most frequently encountered abnormalities in routine blood work, most commonly attributable to non-alcoholic fatty liver disease (NAFLD), estimated to affect roughly 25% of the European adult population. AST (aspartate aminotransferase) is distributed across liver, cardiac muscle, skeletal muscle, kidneys, and brain. While less liver-specific than ALT, the AST-to-ALT ratio carries significant diagnostic value: a ratio exceeding 2 strongly points to alcohol-related liver disease, whereas a ratio below 1 is typical of NAFLD. In advanced fibrosis and cirrhosis, the ratio tends to rise above 1 irrespective of the underlying cause. GGT (gamma-glutamyl transferase) is the most sensitive indicator of biliary disease and responds prominently to alcohol intake — even moderate consumption elevates GGT in many individuals. Isolated GGT elevation with normal ALT and AST is one of the most common incidental laboratory findings, frequently reflecting alcohol use or medication effects (statins, antiepileptics, paracetamol) rather than serious hepatic pathology. Together, these three enzymes detect the vast majority of liver disease encountered in ambulatory medicine. For patients taking medications with known hepatotoxic potential — statins, methotrexate, azole antifungals, antiretrovirals, or long-term NSAIDs — regular monitoring with this panel follows standard clinical guidelines. The Czech Republic has seen rising NAFLD prevalence in line with European trends toward higher obesity rates and sedentary lifestyles. The Moravian diet, while celebrated for its wine and culinary traditions, also contributes to metabolic risk factors that make liver screening relevant. At 101 CZK (~4 EUR), this is among the cheapest liver panels available in Central Europe. For visitors from Austria, where equivalent testing costs 20-40 EUR, the savings are substantial. Blood draw and serum separation are included. Results within two business days.