Longevity.haus
Skinology salon interior — cosmetic studio in Vinohrady, Prague 2
Deep skin cleansing treatment in session at Skinology Prague 2
Diode laser hair removal session at Skinology Prague 2
Mesotherapy treatment at Skinology Prague 2

Microneedling with Mesotherapy Cocktail

Type

Microneedling

Duration

1 hour

What's included

5 deliverables in this treatment

  • Skin consultation and mesotherapy cocktail selection matched to concern
  • Topical anaesthetic application for 20–30 minutes before the procedure
  • Dermapen microneedling pass across the full treatment zone
  • Double cocktail application — before and after needling — for maximum active uptake
  • Calming mask and regenerative finishing cream at close of session

Skinology's microneedling with mesotherapy cocktail combines Dermapen microneedling — a controlled skin puncturing device that creates micro-channels in the dermis — with the application of a customised active ingredient cocktail matched to the client's primary skin concern. The mesotherapy cocktail is applied before and after the Dermapen pass, with the micro-channels dramatically improving the depth and uptake of active ingredients versus topical application alone. Four cocktail formulations are available: a tranexamic acid and vitamin C blend for pigmentation, a hyaluronic acid and B-vitamin mix for anti-ageing and hydration, a collagenase enzyme preparation for acne scars, and a hyaluronic acid, polynucleotide, and exosome combination for rosacea and couperose. The 75-minute session includes topical anaesthesia for comfort. A course of 3–5 sessions at 7–14 day intervals produces the most significant and lasting results.

About this treatment

Microneedling — also known as percutaneous collagen induction — uses a motorised pen device (Dermapen at Skinology) fitted with a disposable sterile tip containing multiple fine needles to create controlled micro-perforations in the skin. These micro-injuries trigger the skin's wound-healing cascade: platelet aggregation, growth factor release, fibroblast recruitment, and ultimately the synthesis of new collagen and elastin — the structural proteins…

How the combination works

The Dermapen creates thousands of micro-channels per pass — at depths of 0.25 mm to 2.5 mm depending on the treatment area and target depth. When a mesotherapy cocktail is applied to the skin immediately before and after needling, these channels provide a direct conduit into the dermis, bypassing the stratum corneum barrier that blocks topical absorption of most active molecules. Absorption of cocktail actives may be enhanced by 40–80% versus surface…

Good to know

Device
Dermapen (sterile disposable tips)
Cocktail options
Pigmentation, anti-ageing, acne scars, rosacea/couperose
Course
3–5 sessions, 7–14 day intervals
Session duration
75 minutes
Anaesthesia
Topical — included

Who is this for?

Rosacea, couperose, PIH, melasma, acne scars, fine lines, dehydrated or dull skin, uneven tone

Preparation required

Avoid retinoids and exfoliating acids for 48 hours before. No sun exposure for 7 days before the session. Arrive with clean skin, no makeup or SPF. Notify the cosmetologist of any history of herpes labialis — antiviral prophylaxis may be recommended.

About the clinic

Reviews, team and credentials

Independent review links and clinic-reported team information.

Clinical team

Skinology is staffed by two cosmetologists: Anastasia Kuznetsova (founder) brings 7+ years of professional experience in medicine and biology with deep expertise in chemical peeling protocols (AHA, BHA, Jessner, TCA, retinol), skin cleansing, and mesotherapy. Angelina (3+ years experience) specialises in RF-lifting, non-injection mesotherapy, microdermabrasion, and laser hair removal operation. Together they cover…

Languages: Czech, English, Russian

View the full Skinology profile
Compare Microneedling in Czechia →