DUTCH Test — Hormone Assessment

The DUTCH Test (Dried Urine Test for Comprehensive Hormones) at Regenevéda provides a detailed map of sex and adrenal hormone levels, hormone metabolites, and cortisol patterns via a dried urine collection performed at home. Priced at $500 and sold directly through the clinic's online store, the DUTCH panel goes beyond serum hormone snapshots by capturing how hormones are produced, converted, and cleared — revealing whether elevated or suppressed levels stem from production issues, receptor sensitivity differences, or detoxification pathway imbalances. Results are reviewed in context with Dr. Thom Lobe's bioidentical hormone replacement therapy programme.

The DUTCH Test (Dried Urine Test for Comprehensive Hormones) offered at Regenevéda and priced at $500 is a specialty urinary hormone panel developed by Precision Analytical Inc. and widely used in integrative and functional medicine for its ability to capture not just circulating hormone levels but the full metabolic pathway through which hormones are synthesised, interconverted, and excreted. This distinguishes the DUTCH panel from standard serum hormone tests, which provide a single-time-point concentration of a hormone in blood but cannot reveal whether that concentration is low due to inadequate production, excessive clearance, conversion into an alternative metabolite, or poor receptor-level signalling. The DUTCH panel captures free cortisol and cortisol metabolites — critically including the diurnal pattern of cortisol across four to five collection points throughout the day and into the evening — enabling evaluation of the hypothalamic-pituitary-adrenal (HPA) axis rhythm. Disrupted cortisol rhythm (blunted morning peak, flattened curve, or inverted pattern) is associated with chronic stress, burnout, sleep disorder, and immune dysregulation in functional medicine frameworks. The sex hormone section of the DUTCH panel covers oestrone (E1), oestradiol (E2), and oestriol (E3) with their respective phase-I and phase-II liver detoxification metabolites — notably the 2-hydroxy, 4-hydroxy, and 16-alpha-hydroxy oestrogen metabolites, whose ratio has been researched in relation to breast cancer risk. Progesterone metabolites (pregnanediol, allopregnanolone), androgens (DHEA, testosterone, androsterone, etiocholanolone), and methylation efficiency markers (including the 2-OHE1:2-MeOE1 ratio) are also reported. At Regenevéda, the DUTCH Test informs the design of bioidentical hormone replacement therapy prescriptions compounded to address the patient's specific hormonal pattern. The test kit is collected at home over a 24-hour period and mailed to the laboratory; results are reviewed with the clinical team. The clinic is located at 8 S Michigan Ave, Suite 812, Chicago IL 60603.