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Quest Diagnostics Quest Diagnostics

Comprehensive Metabolic Panel (CMP)

Type

Blood Testing

Biomarkers

21

Duration

30 min

Results

24 hours

Comprehensive blood test assessing liver and kidney function, hypertension, proteins, blood sugar, and calcium.

The comprehensive metabolic panel (CMP) helps assess overall health, detect early signs of disease, and monitor chronic conditions. It measures 14 components: blood sugar (glucose), calcium, total protein, liver enzymes, bilirubin, blood urea nitrogen, creatinine, albumin, carbon dioxide, and key electrolytes. Abnormal CMP test results may indicate various health conditions, such as developing or active liver or kidney disease, hypertension, or diabetes. With Quest, you can buy a CMP test online and get testing at a nearby location – no doctor’s visit required.

Key Details

Biomarkers
2–4 metabolic markers
Fasting Required
Yes, 10–12 hours for fasting glucose
Sample Type
Blood draw
Turnaround
Same day to 24 hours
Common Use
Diabetes screening, insulin resistance detection

Who Is This For?

Adults over 35 as part of routine screening (diabetes affects 1 in 10 adults globally). Anyone with a family history of type 2 diabetes. People who are overweight or physically inactive. Those experiencing increased thirst, frequent urination, unexplained weight loss, or fatigue. Women with a history of gestational diabetes or polycystic ovary syndrome (PCOS).

What's Included

Fasting blood glucose
HbA1c (glycated hemoglobin)
Fasting insulin (if included in panel)
HOMA-IR insulin resistance index (if insulin included)

Preparation Required

Fasting for 10–12 hours before your appointment is recommended for accurate results (water is fine). Avoid alcohol for 24 hours and intense exercise for 12 hours before the blood draw. Morning appointments are ideal for consistent hormone and glucose readings. The blood draw typically takes 5–10 minutes.

Biomarkers Tested

21
Alkaline Phosphatase (ALP) U/L

An enzyme found in the liver, bones, kidneys, and digestive system. Elevated ALP can indicate bile duct obstruction, liver disease, or bone disorders. It's normally higher in children and during pregnancy due to bone growth.

ALT (Alanine Aminotransferase) U/L

A liver enzyme that helps convert proteins into energy. ALT is found primarily in the liver, making it a highly specific marker for liver damage. Elevated levels may indicate hepatitis, fatty liver disease, or medication-related liver injury.

AST (Aspartate Aminotransferase) U/L

An enzyme found in the liver, heart, and muscles. While less liver-specific than ALT, elevated AST can indicate liver damage, heart attack, or muscle injury. The AST/ALT ratio helps distinguish between different liver conditions.

Bilirubin mg/dL

Bilirubin is a substance produced during the normal breakdown of red blood cells. High levels can lead to jaundice and indicate liver or bile duct problems.

Urea mg/dL

A waste product from protein breakdown, processed by the liver and excreted by the kidneys. Elevated urea levels can indicate kidney dysfunction, dehydration, high-protein diet, or gastrointestinal bleeding.

Creatinine mg/dL

A waste product from normal muscle metabolism, filtered by the kidneys. Blood creatinine levels reflect kidney filtration capacity. Elevated levels may indicate impaired kidney function, dehydration, or excessive muscle breakdown.

Albumin g/dL

The most abundant protein in blood, produced by the liver. Albumin maintains blood volume and pressure, and transports hormones, vitamins, and drugs. Low levels indicate liver disease, kidney disease, malnutrition, or chronic inflammation.

Total Protein g/dL

Measures the combined amount of albumin and globulin proteins in your blood. These proteins are essential for fighting infections, blood clotting, and transporting substances throughout the body.

Glucose mg/dL

Blood sugar — the body's primary energy source. Fasting glucose screens for diabetes and prediabetes. Chronically elevated glucose damages blood vessels and organs. Levels fluctuate with meals, stress, and physical activity.

Calcium mg/dL

The most abundant mineral in the body, essential for bone health, muscle contraction, nerve function, and blood clotting. Blood calcium is tightly regulated by parathyroid hormone and vitamin D. Abnormal levels can indicate parathyroid disorders.

Carbon Dioxide (CO2) mEq/L

Measures the total CO2 content in blood, primarily as bicarbonate. It reflects the acid-base balance maintained by the lungs and kidneys. Abnormal levels can indicate respiratory or metabolic acidosis or alkalosis.

Chloride mEq/L

An electrolyte that works with sodium to maintain fluid balance, blood pressure, and acid-base balance. Chloride abnormalities often accompany sodium abnormalities and can indicate dehydration, kidney disease, or metabolic disorders.

Potassium mEq/L

A critical electrolyte for heart rhythm, muscle contractions, and nerve function. Both high and low potassium can cause dangerous cardiac arrhythmias. Levels are influenced by kidney function, medications, and diet.

Sodium mEq/L

The primary electrolyte regulating fluid balance and blood pressure. Sodium is essential for nerve impulses and muscle contractions. Abnormal levels can cause confusion, seizures, and cardiac arrhythmias.

Globulin g/dL

A group of proteins in blood including antibodies (immunoglobulins), transport proteins, and enzymes. Elevated globulin can indicate chronic infection, inflammation, or blood cancers. Calculated by subtracting albumin from total protein.

Albumin g/dL

The most abundant protein in blood, produced by the liver. Albumin maintains blood volume and pressure, and transports hormones, vitamins, and drugs. Low levels indicate liver disease, kidney disease, malnutrition, or chronic inflammation.

Creatinine mg/dL

A waste product from normal muscle metabolism, filtered by the kidneys. Blood creatinine levels reflect kidney filtration capacity. Elevated levels may indicate impaired kidney function, dehydration, or excessive muscle breakdown.

Albumin/Globulin Ratio (A/G Ratio) ratio

The ratio of albumin to globulin proteins in blood. A low A/G ratio may indicate overproduction of globulins (as in multiple myeloma or autoimmune disease) or underproduction of albumin (liver disease).

Estimated Glomerular Filtration Rate (eGFR) mL/min/1.73m²

An estimated measure of how well your kidneys filter waste from the blood. It's calculated from creatinine levels, age, sex, and race. eGFR is the primary marker used to stage chronic kidney disease.

HbA1c (Glycated Haemoglobin) %

Reflects your average blood sugar over the past 2–3 months by measuring the percentage of hemoglobin with attached glucose. HbA1c is the gold standard for diagnosing and monitoring diabetes, unaffected by daily fluctuations.

Insulin µIU/mL

The hormone produced by the pancreas to regulate blood sugar. Elevated fasting insulin — even with normal glucose — is an early marker of insulin resistance, which precedes type 2 diabetes by years. Key biomarker in longevity medicine.

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Price
$49.00

+ $6.00 Physician Service Fee

Category
Diagnostic
Sample Type
Blood draw
Duration
30 min
Results
24 hours