Tissue Stimulator — Polynucleotides (PDRN/PN)

Polynucleotide (PDRN/PN) tissue stimulator injection at QLINIQUE Warsaw. 1,099 PLN per session, with a 3-session package at the same effective price. Improves skin hydration, reduces fine lines, and stimulates collagen through DNA repair mechanisms.

Polynucleotides (PN) — also sold under brand names such as Ameela, Plenhyage, Plinest, and PDRN preparations from salmon DNA — are injectable biostimulators derived from purified DNA fragments. At QLINIQUE, the 3-session package is priced at 1,099 PLN (equivalent to the single-session price), effectively delivering the complete therapeutic course for the cost of one session — an exceptionally competitive offering. Polynucleotides work through two primary mechanisms. First, the fragments are hydrophilic and bind water strongly, providing deep dermal hydration independent of volume augmentation. Second, the DNA-derived fragments stimulate tissue repair machinery — including fibroblast proliferation, growth factor expression (VEGF, FGF, IGF), and collagen synthesis — through interaction with adenosine receptors in the dermis. Clinical studies demonstrate measurable improvement in skin elasticity, hydration indices, and surface texture after a 3-session protocol spaced 2 to 4 weeks apart. Differences from HA skin boosters: polynucleotides produce their effect through cellular stimulation rather than direct volumising hydration. The improvement is more gradual than Profhilo or classic HA boosters but tends to be longer lasting (6 to 12 months from a completed course) and produces qualitative skin improvements (texture, elasticity, luminosity) rather than just hydration. The broader tissue stimulator menu at QLINIQUE covers the full generation of modern biostimulators: polycaprolactone (PCL, 1,399–1,599 PLN) for gentle long-term collagen stimulation; calcium hydroxyapatite / Radiesse (1,399–1,799 PLN) for combined immediate volumising and collagen stimulation; and poly-L-lactic acid / Sculptra (2,099–3,799 PLN) for the deepest, longest-lasting pure collagen stimulus.