Regenerative Aesthetics — Collagen Biostimulators & Biologics

A medically guided regenerative aesthetics programme using collagen biostimulators — including PLLA-SA (poly-L-lactic acid) and PCL-CMC — to rebuild lost facial and body volume, restore skin structure, and achieve long-lasting rejuvenation through the body's natural collagen production cascade.

NU.U Aesthetics & Wellness has built a comprehensive regenerative aesthetics programme centred on the use of collagen biostimulators and biological agents that trigger the body's own repair and renewal pathways. Unlike hyaluronic acid fillers that provide temporary volume through a foreign material, biostimulators work by activating fibroblasts to produce new collagen — delivering progressive, natural-looking results that develop over months and last considerably longer. The clinic's regenerative portfolio includes PLLA-SA (poly-L-lactic acid combined with sodium acrylate), which is injected into the dermis and subdermis to provide an immediate volumising scaffold while simultaneously stimulating long-term collagen neogenesis. PLLA-SA products offer results lasting up to two years in clinical studies. Polycaprolactone-carboxymethylcellulose (PCL-CMC) is another biostimulator offered at NU.U, releasing collagen-stimulating signals over an extended period with a strong safety and efficacy record for facial and body applications. The clinic also offers Linerase, a collagen-enzyme product that facilitates the breakdown of degraded collagen while simultaneously encouraging regeneration of healthy collagen and hyaluronic acid. Ultracol (PDO microspheres) provides an additional option using biodegradable polydioxanone particles to trigger collagen stimulation across treatment areas including the face, neck, and body. All regenerative treatments are individually assessed and administered by Dr K.K. Chew, who draws on over 22 years of aesthetic medicine experience to select the most appropriate biostimulator for each patient's skin condition, age, treatment history, and goals. Treatment protocols typically involve two to four sessions spaced four to six weeks apart, with a comprehensive post-treatment care plan to maximise biological response. Regenerative biostimulator therapy at NU.U is well-suited to patients seeking long-term skin quality improvement, natural-looking volume restoration, or those looking to build on results from injectable treatments or laser procedures with a foundation of new collagen.