Polynucleotide (PNHPT) & Exosome Regenerative Injections

Clinically administered polynucleotide (PNHPT/Rejuran) and exosome injections that stimulate skin repair, collagen synthesis, and tissue regeneration. Addresses skin laxity, texture irregularities, fine lines, and dull complexion through the body's own biological renewal mechanisms.

NU.U Aesthetics & Wellness offers a suite of regenerative injection therapies — including polynucleotide (PNHPT) treatments and exosome-based biologics — that harness the body's own biological signalling pathways to restore skin quality from within. These treatments represent the clinic's regenerative aesthetics philosophy: lasting improvement through biological stimulation rather than surface-level masking. Polynucleotide treatments (branded as Rejuran, Plinest, or PNHPT) involve injecting DNA fragments derived from natural sources into the dermis. These polynucleotide chains act as biological scaffolds that stimulate fibroblast activity, boosting collagen and elastin synthesis while also providing anti-inflammatory and hydrating benefits. The result is a progressive improvement in skin density, elasticity, and hydration — typically becoming visible over four to eight weeks following a series of sessions. Rejuran and its equivalents are widely used in Singapore and Korea for overall skin rejuvenation, scar healing, and addressing fine lines without altering facial structure. Exosome therapy at NU.U uses extracellular vesicles derived from stem cell sources to deliver concentrated growth factors and signalling proteins directly into the skin. These microscopic vesicles activate the skin's own regenerative processes — promoting cellular turnover, collagen production, and tissue repair. Exosome treatments are particularly valued for their ability to improve skin tone, texture, and radiance, and they are often combined with laser or microneedling procedures to amplify uptake and results. All injectable treatments at NU.U Aesthetics & Wellness are administered by Dr K.K. Chew or under his direct medical supervision, following the Ministry of Health Singapore's guidelines for aesthetic injectables. A thorough consultation precedes every treatment plan to assess skin condition, identify target concerns, and determine the most appropriate biological agent and dosing protocol. A typical programme involves two to four sessions spaced three to four weeks apart, followed by maintenance sessions every three to six months. Polynucleotide and exosome treatments can be combined with other NU.U offerings such as Morpheus 8, laser treatments, or collagen biostimulators for patients seeking comprehensive skin restoration.