PRF Hair Loss Treatment (Platelet-Rich Fibrin)

Platelet-Rich Fibrin (PRF) is an advanced second-generation form of PRP in which a fibrin matrix retains growth factors at the injection site for prolonged release over days to weeks. Blood is spun at lower centrifuge speed without anticoagulants, producing a fibrin gel scaffold containing platelets, leukocytes, and stem cells. PRF may support follicle regeneration and scalp health over a longer duration than standard PRP. Three to four sessions 4–6 weeks apart, with 1–2 maintenance sessions per year.

Nova Medical Hair Transplant NYC offers Platelet-Rich Fibrin (PRF) as a next-generation alternative to conventional PRP for hair loss treatment. PRF is produced by centrifuging the patient's blood at a lower speed and without the anticoagulant additives used in standard PRP preparation. The slower spin speed and absence of anticoagulant allow the natural coagulation cascade to begin, converting fibrinogen in the plasma into a fibrin gel that forms a three-dimensional scaffold within the processed sample. This fibrin scaffold traps and retains the activated platelets, leukocytes (white blood cells), and circulating stem cells that would otherwise be lost or quickly dispersed after injection. When PRF is injected into the scalp, the fibrin matrix functions as a slow-release reservoir for growth factors including PDGF, VEGF, TGF-β, and IGF-1 — releasing them gradually over a period of seven to fourteen days or longer, compared to the more rapid one to three day release profile associated with standard liquid PRP preparations. This extended growth factor availability at the follicular level is associated with a more sustained biostimulatory signal per session and may require fewer total sessions to achieve a comparable response. The leukocyte content of PRF is also higher than in standard PRP, which contributes an anti-inflammatory component that may support scalp tissue health and follicular environment. PRF is injected into the scalp in a similar grid pattern to PRP, targeting areas of miniaturisation and active shedding. Sessions run approximately sixty minutes. A course of three to four sessions spaced four to six weeks apart is recommended, followed by one to two maintenance sessions per year to sustain the treatment effect. PRF may be used as a standalone treatment or in combination with surgical hair transplant procedures.