Biostimulatory Fillers (Profhilo & Nucleofill)

Biostimulatory fillers — Profhilo and Nucleofill — are a category of injectable skin treatment that works by stimulating the skin's own collagen and elastin rather than simply adding volume. Profhilo contains an unusually high concentration of hyaluronic acid (64 mg/2 ml) that spreads broadly through the dermis once injected, delivering intense hydration and activating four types of collagen simultaneously. Nucleofill uses PDRN technology, the same salmon-derived DNA complex found in Rejuran, to repair and regenerate skin cells from within. Neo Beauty Clinic offers both products across face, neck and décolletage.

Biostimulatory fillers represent a distinct category between conventional HA dermal fillers (which add volume) and skin boosters (which focus on surface hydration). Their primary mechanism is cellular — they activate the skin's own fibroblasts to produce new structural proteins rather than passively filling tissue. **Profhilo (7,000 Kč / 2 ml; two-session protocol 12,500 Kč):** Contains a very high concentration of ultra-pure hyaluronic acid (approximately 64 mg per 2 ml) without any chemical cross-linking agents. This 'free' HA disperses rapidly through tissue planes after injection via just five injection points per side (the BAP — Bio Aesthetic Points — technique), migrating broadly rather than staying localised. It simultaneously stimulates four types of collagen (I, III, IV and VII) and two types of elastin, produces deep hydration and has remodelling effects on lax skin. The standard protocol is two sessions four weeks apart. Suitable for the face, neck, décolletage and hands. **Nucleofill (PDRN-based; 3,000–6,000 Kč per session):** Available in Soft Eyes (lighter formulation for the periorbital area) and Strong (for broader skin areas), Nucleofill uses the same polydeoxyribonucleotide technology as Rejuran, binding to adenosine receptors to stimulate tissue repair, reduce inflammation and accelerate cellular turnover. Four-session packages at 18,000–20,000 Kč deliver the sustained collagen stimulus. Both treatments are low-downtime: mild redness and small wheals resolve within hours to one day. There is no need to avoid normal daily activities beyond avoiding exercise and heat for the rest of the treatment day.