MTHFR Genetic Test

Single-gene genetic test for MTHFR variants that affect folate metabolism, methylation capacity, and cardiovascular risk. Available as an add-on to Mito Health membership.

Mito Health offers MTHFR genetic testing as an a la carte add-on for members who want to understand their methylation status and folate processing capacity. The MTHFR (methylenetetrahydrofolate reductase) gene encodes an enzyme critical to the conversion of folate into its active form (5-MTHF). Common variants — C677T and A1298C — are associated with reduced enzyme activity, elevated homocysteine levels, and increased risk of cardiovascular disease, neural tube defects, and mood disorders. Identifying MTHFR status allows the clinical team to personalise supplementation recommendations: carriers of the C677T variant, for example, benefit from active folate (methylfolate) rather than synthetic folic acid. The test is a simple blood or saliva sample coordinated through Mito Health's partner labs in Singapore, with results integrated into the member's health dashboard alongside their blood panel data. The clinical team reviews MTHFR results in the context of the full biomarker picture — particularly homocysteine and B12 levels — to provide a coherent, actionable supplement and dietary protocol. This is a practical, cost-effective entry point into genetic health optimisation for Singaporeans, complementing the broader longevity panel without requiring a full pharmacogenomics workup.