Whole-Genome Predictive Screening

MCP's whole-genome predictive screening provides a comprehensive map of your inherited disease risk across six major biological domains: metabolic, oncological, neurological, endocrine, cardiovascular, and immunological. The analysis is performed through MCP's accredited genomic lab partners and interpreted by MUDr. Silvie Růžičková (genetics) and MUDr. Radek Klubal. Unlike direct-to-consumer ancestry tests, this is a clinically framed risk assessment with actionable recommendations for screening frequency, lifestyle modification, and preventive intervention.

Predictive genomic medicine is changing how proactive individuals approach long-term health. MCP's whole-genome screening programme is designed for patients who want a comprehensive picture of their inherited disease predispositions — not just ancestry data, but clinically interpreted risk information that drives real preventive decisions. The analysis is performed through MCP's specialist genomic laboratory partners using next-generation sequencing (NGS) technology. Blood is drawn at the Praha 4 clinic by MCP's nursing team, processed through the accredited partner lab network, and the interpreted results are delivered in a structured physician consultation. Domains covered in the report: **Metabolic**: MTHFR (folate/homocysteine metabolism), APOE (cholesterol and Alzheimer's risk), PCSK9 (familial hypercholesterolaemia), TCF7L2 (type 2 diabetes), FTO and MC4R (obesity predisposition), haemochromatosis (HFE gene) **Oncological**: BRCA1/2 (breast and ovarian cancer), Lynch syndrome genes (MLH1, MSH2, MSH6, PMS2) for colorectal/endometrial cancer, APC (familial adenomatous polyposis), RET (thyroid cancer), TP53, CHEK2, ATM, PALB2 **Neurological**: APOE4 (Alzheimer's), LRRK2/SNCA/PARK2 (Parkinson's), HTT (Huntington's), hereditary motor neuropathy genes, MTHFR (neurological folate metabolism) **Endocrine**: thyroid function variants, adrenal cortisol pathway genes, HLA types linked to autoimmune endocrine disease (Type 1 diabetes, Hashimoto's, Graves') **Cardiovascular**: SCN5A, KCNQ1, KCNH2 (inherited arrhythmia), MYH7, MYBPC3 (hypertrophic cardiomyopathy), LDLR/APOB/PCSK9 (familial hypercholesterolaemia), F5 (Factor V Leiden, thrombophilia) **Immunological**: HLA alleles (autoimmune disease risk, transplant compatibility, vaccine response), primary immunodeficiency variants, complement gene variants Results are delivered in a structured physician consultation with MUDr. Růžičková and MUDr. Klubal. The report distinguishes high-penetrance pathogenic variants (where finding is clinically significant regardless of lifestyle) from polygenic risk scores (cumulative risk from common variants). Each finding includes a recommended action — ranging from increased screening frequency to specific supplementation, lifestyle modification, or specialist referral.