Celiac Disease & Intolerance Genetic Testing

MCP offers dedicated genetic and functional diagnostics for the three most common diet-related intolerances in Czech patients: celiac disease, lactose intolerance, and histamine intolerance. Each condition has a genetic component that a standard food sensitivity test misses — HLA-DQ2/DQ8 typing for celiac, LCT gene variants for lactose, and DAO enzyme gene variants for histamine. The combined genetic + functional approach gives a definitive answer rather than a probabilistic food panel result, and guides dietary management with precision.

Diet-related intolerances are among the most under-diagnosed conditions in Central Europe. Standard IgG food sensitivity panels — widely sold commercially — do not distinguish genetic predisposition from transient reactivity, and have no diagnostic validity for celiac disease. MCP uses a genetically grounded diagnostic pathway for each condition. **Celiac Disease (Celiakie)** Celiac disease is an autoimmune disorder triggered by gluten in genetically susceptible individuals. MCP's diagnostic protocol covers: - **HLA-DQ2 and HLA-DQ8 genetic typing** — the two alleles present in >99% of celiac patients. Negative result effectively excludes genetic predisposition. - **Celiac antibody panel**: anti-tTG IgA, EMA IgA, DGP IgG/IgA, total IgA (to exclude IgA deficiency, which causes false-negative tTG results) - **Supplementary**: lactose tolerance/challenge tests, abdominal ultrasound, and intestinal biopsy coordination if antibodies are elevated **Lactose Intolerance (Laktózová intolerance)** Lactase non-persistence — inherited insufficiency of the lactase enzyme — is the most common cause. MCP tests: - **LCT gene variants** (C/T-13910 polymorphism) — the genetic marker for adult lactase non-persistence in European populations - **Functional testing**: hydrogen breath test after lactose load (distinguishes primary from secondary lactose intolerance) **Histamine Intolerance (Histaminová intolerance)** Diamine oxidase (DAO) enzyme deficiency impairs histamine degradation, causing diverse symptoms from headache and flushing to digestive complaints. MCP assesses: - **AOC1/DAO gene variants** — associated with reduced DAO enzyme activity - **Clinical symptom correlation** — histamine intolerance is a clinical diagnosis supported by genetic risk assessment; no single test is definitive Results are reviewed by MUDr. Radek Klubal or MUDr. Silvie Růžičková (genetics) and reported with a precise dietary management plan, including guidance on threshold doses, enzyme supplementation, and low-histamine dietary protocols.