Type
Blood Testing
Biomarkers
9
Duration
45 min
What's included
6 deliverables in this treatment
- HLA-DQ2/DQ8 genetic typing (celiac predisposition)
- Celiac antibody panel (anti-tTG IgA, EMA IgA, DGP IgG/IgA, total IgA)
- LCT gene variant analysis (lactose intolerance, if selected)
- DAO/AOC1 gene variant analysis (histamine intolerance, if selected)
- Functional breath test option (lactose hydrogen breath test)
- Written report with dietary management plan
MCP offers dedicated genetic and functional diagnostics for the three most common diet-related intolerances in Czech patients: celiac disease, lactose intolerance, and histamine intolerance. Each condition has a genetic component that a standard food sensitivity test misses — HLA-DQ2/DQ8 typing for celiac, LCT gene variants for lactose, and DAO enzyme gene variants for histamine. The combined genetic + functional approach gives a definitive answer rather than a probabilistic food panel result, and guides dietary management with precision.
About this treatment
Diet-related intolerances are among the most under-diagnosed conditions in Central Europe. Standard IgG food sensitivity panels — widely sold commercially — do not distinguish genetic predisposition from transient reactivity, and have no diagnostic validity for celiac disease. MCP uses a genetically grounded diagnostic pathway for each condition.
Celiac Disease (Celiakie)
Celiac disease is an autoimmune disorder triggered by gluten in genetically susceptible individuals. MCP's diagnostic protocol covers: - HLA-DQ2 and HLA-DQ8 genetic typing — the two alleles present in >99% of celiac patients. Negative result effectively excludes genetic predisposition. - Celiac antibody panel: anti-tTG IgA, EMA IgA, DGP IgG/IgA, total IgA (to exclude IgA deficiency, which causes false-negative tTG results) - Supplementary: lactose…
Good to know
- Celiac genetics
- HLA-DQ2/DQ8 typing — excludes or confirms genetic predisposition
- Lactose
- LCT C/T-13910 polymorphism + breath test
- Histamine
- DAO/AOC1 gene variants + clinical assessment
- Genetics lead
- MUDr. Silvie Růžičková
Who is this for?
Persistent digestive symptoms, suspected celiac or gluten sensitivity, bloating after dairy, histamine-type reactions (flushing, headaches, urticaria after high-histamine foods)
Preparation required
For celiac antibody testing: maintain a gluten-containing diet for at least 6 weeks before the test. For lactose breath test: fast 12 hours before. Book via extranet.mc-praha.cz.
Panel categories
Biomarkers tested
9Indicates immunity against HBV due to vaccination or previous infection.
Detects antibodies to hepatitis C virus, indicating current or past infection. A positive result requires confirmatory RNA testing. Hepatitis C is now curable with direct-acting antiviral medications in most patients.
Immunoglobulin E (IgE) is a protein associated with allergic reactions that is normally found in very small amounts in the blood. IgE functions as part of the body's immune system (its defence against 'intruders').
Immunoglobulin G (IgG) is the most common type of antibody in the blood, important for fighting bacterial and viral infections.
Imbalances in gut pH influence short-chain fatty acid production and their effects.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
Clinical team
MUDr. Radek Klubal (founder, managing director, clinical immunologist) leads a team that includes MUDr. Silvie Růžičková (clinical genetics, reproductive medicine), MUDr. Barbora Klubalová (venereology, dermatology), Ing. Silvia Illýová (nutritional counsellor, BSc Human Nutrition, SPU Nitra), and Pavla Schubertová, Dis. (head nurse). All physicians hold Czech specialist licences in their respective fields.
Languages: cs, en
Treatment highlights
- HLA-DQ2/DQ8 genetic typing (celiac predisposition)
- Celiac antibody panel (anti-tTG IgA, EMA IgA, DGP IgG/IgA, total IgA)
+4 more items in What's included
From 3,500 Kč per diagnostic package. Price confirmed at booking. Covers HLA-DQ2/DQ8 genetic typing, celiac antibody panel, and supplementary functional tests (lactose breath test, histamine intolerance DAO enzyme analysis) depending on which intolerance package is selected.