Type
Botox & Fillers
Duration
1 hour
What's included
3 deliverables in this treatment
- Physician consultation and zone assessment
- Numbing cream application
- Polynucleotide injection treatment (Nucleofill or Vitaran II)
Polynucleotide (PDRN) biostimulators are injectable regenerative agents derived from highly purified salmon or trout DNA. At MarBelle Clinic, the Nucleofill and Vitaran II ranges are used to stimulate cellular regeneration at a deeper biological level than conventional HA fillers — rather than adding volume, they signal fibroblasts to produce new collagen, elastin, and extracellular matrix components. The treatment is particularly effective for addressing loss of facial oval definition, neck laxity, periorbital thinning (hollowing under and around the eyes), and overall skin quality decline. Sessions include numbing preparation.
About this treatment
Polynucleotides (PN) — also marketed under the abbreviation PDRN (polydeoxyribonucleotide) — represent one of the most evidence-backed categories of injectable biostimulation available. Derived from purified fish roe DNA and processed into fragments of specific molecular weight ranges, these molecules interact with adenosine A2A receptors on fibroblasts and tissue macrophages, triggering anti-inflammatory and regenerative cascades that result in increased…
Unlike HA fillers, which provide immediate volumetric effect and rely on mechanical tissue displacement, PN treatments produce results that build gradually over four to eight weeks as the cellular response unfolds. Patients who want structural volume restoration are better served by fillers; patients whose primary concern is skin quality — texture, hydration, elasticity, and the overall 'thinness' that develops in ageing skin — are strong candidates for…
At MarBelle Clinic, Nucleofill is used for facial and neck biostimulation across the mid-dermis, while Vitaran II is particularly suited to the delicate periorbital zone around the eyes — an area with thin, vulnerable skin where traditional fillers carry higher vascular complication risks. The treating physician places injections using fine-gauge needles in a systematic microinjection pattern, targeting the dermis and deep epidermis rather than the…
Good to know
- Products
- Nucleofill, Vitaran II, Redensity 1
- Mechanism
- Cellular biostimulation via A2A receptor
- Results timeline
- 4–8 weeks (gradual build)
- Sessions recommended
- 2–4 sessions at 3–4 week intervals
- Best for
- Skin quality, periorbital thinning, neck laxity
Who is this for?
Skin quality decline, periorbital hollowing, neck and décolletage laxity, overall skin regeneration in patients with thin or mature skin
Preparation required
Avoid blood thinners 5–7 days before if medically possible. Arrive makeup-free. Inform physician of any allergies to fish-derived products.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
Clinical team
The clinic is led by Prim. MUDr. Martina Matzenauer, founder and CEO, a dermatologist who holds a primary specialisation in dermatovenerology and has developed the clinic's philosophy of psychodermatology integration — treating the connection between skin health and patient wellbeing. Plastic surgery is performed by MUDr. Pavel Xinopulos and MUDr. Richard Billich, Ph.D., both certified plastic surgeons. The clinical…
Languages: cs, en
Treatment highlights
- Physician consultation and zone assessment
- Numbing cream application
+1 more item in What's included
From 5,000 Kč per session. Eye area with Vitaran II: 3,000 Kč. Redensity 1 (periorbital): 3,000 Kč. Price varies by product and zone treated. Numbing cream included.