Polynucleotide Biostimulators (Nucleofill / Vitaran II)

Polynucleotide (PDRN) biostimulators are injectable regenerative agents derived from highly purified salmon or trout DNA. At MarBelle Clinic, the Nucleofill and Vitaran II ranges are used to stimulate cellular regeneration at a deeper biological level than conventional HA fillers — rather than adding volume, they signal fibroblasts to produce new collagen, elastin, and extracellular matrix components. The treatment is particularly effective for addressing loss of facial oval definition, neck laxity, periorbital thinning (hollowing under and around the eyes), and overall skin quality decline. Sessions include numbing preparation.

Polynucleotides (PN) — also marketed under the abbreviation PDRN (polydeoxyribonucleotide) — represent one of the most evidence-backed categories of injectable biostimulation available. Derived from purified fish roe DNA and processed into fragments of specific molecular weight ranges, these molecules interact with adenosine A2A receptors on fibroblasts and tissue macrophages, triggering anti-inflammatory and regenerative cascades that result in increased collagen and elastin synthesis, improved extracellular matrix organisation, and enhanced tissue hydration. Unlike HA fillers, which provide immediate volumetric effect and rely on mechanical tissue displacement, PN treatments produce results that build gradually over four to eight weeks as the cellular response unfolds. Patients who want structural volume restoration are better served by fillers; patients whose primary concern is skin quality — texture, hydration, elasticity, and the overall 'thinness' that develops in ageing skin — are strong candidates for polynucleotide biostimulation. At MarBelle Clinic, Nucleofill is used for facial and neck biostimulation across the mid-dermis, while Vitaran II is particularly suited to the delicate periorbital zone around the eyes — an area with thin, vulnerable skin where traditional fillers carry higher vascular complication risks. The treating physician places injections using fine-gauge needles in a systematic microinjection pattern, targeting the dermis and deep epidermis rather than the subcutaneous layer. Typically two to four sessions are recommended at three-to-four-week intervals to establish the biological remodelling response, with results lasting six to twelve months before maintenance is needed. The treatment is often combined with other modalities — PRP, skinboosters, or microneedling — for multi-mechanism skin regeneration protocols. Side effects are mild: transient redness, minimal swelling, and occasional small injection-point bruises resolve within 24–48 hours. The product's high biocompatibility means allergic reactions are very rare, and the material is fully biodegradable.