Type
Botox & Fillers
Duration
1 hour
What's included
3 deliverables in this treatment
- Initial medical consultation and muscle assessment
- Botulinum toxin injection treatment (Letybo, Alluzience, or Dysport)
- 2-week review appointment included
Botulinum toxin injections at MarBelle Clinic are performed by licensed physicians using EMA-approved products — Letybo, Alluzience, and Dysport — allowing the treating doctor to select the preparation best suited to each patient's muscle anatomy and desired outcome. The treatment targets dynamic wrinkles formed by repetitive facial muscle contractions: the glabella (frown lines), forehead, and lateral orbital zone (crow's feet). By temporarily blocking the neuromuscular signal to targeted muscles, it softens active lines while leaving untreated facial movement unaffected. Results become visible within 7–14 days and typically last three to six months.
About this treatment
Botulinum toxin type A is the most studied injectable in aesthetic medicine, with decades of safety data and a mechanism of action well understood at the molecular level. At MarBelle Clinic in Olomouc, the product choice is a clinical decision made in consultation with the patient: Letybo is a more recently approved formulation with evidence for a precise diffusion profile, Alluzience is a ready-to-use liquid formulation that eliminates reconstitution…
The mechanism is straightforward: botulinum toxin binds irreversibly to the presynaptic membrane of the neuromuscular junction, blocking the release of acetylcholine and preventing the muscle from receiving the signal to contract. This is a temporary block — as the toxin breaks down over three to six months, the nerve terminal regenerates new synaptic contacts and muscle function gradually returns. The goal of treatment is not complete paralysis but…
At the consultation, the dermatologist or physician assesses the patient's muscle mass, resting line depth, and the degree of dynamic movement to determine both the target muscles and the number of units required. This assessment is more nuanced than a fixed-dose protocol: a patient with strong frontalis muscles and deep horizontal forehead lines requires different dosing than a patient with subtle lines seeking pure prevention.
Good to know
- Products used
- Letybo, Alluzience, Dysport (physician's choice)
- Results visible
- 7–14 days post-treatment
- Duration of effect
- 3–6 months
- Downtime
- None — return to work same day
- 2-week review
- Included
Who is this for?
Dynamic wrinkles — forehead lines, frown lines (glabella), crow's feet — patients seeking natural softening of expression lines
Preparation required
Avoid blood-thinning medications and supplements (aspirin, ibuprofen, fish oil, vitamin E) for 5–7 days before if medically safe to do so. Avoid alcohol 24 hours before. Arrive makeup-free to the treatment area.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
Clinical team
The clinic is led by Prim. MUDr. Martina Matzenauer, founder and CEO, a dermatologist who holds a primary specialisation in dermatovenerology and has developed the clinic's philosophy of psychodermatology integration — treating the connection between skin health and patient wellbeing. Plastic surgery is performed by MUDr. Pavel Xinopulos and MUDr. Richard Billich, Ph.D., both certified plastic surgeons. The clinical…
Languages: cs, en
Treatment highlights
- Initial medical consultation and muscle assessment
- Botulinum toxin injection treatment (Letybo, Alluzience, or Dysport)
+1 more item in What's included
From 2,400 Kč per session (minimum session). Charged per unit of product used: Letybo 150 Kč/unit, Alluzience 72 Kč/unit, Dysport 60 Kč/unit. The physician determines the required units during consultation. A 2-week review is included.