Collagen Stimulators & Biostimulators

Lili Clinic offers one of the most comprehensive biostimulator menus in the Prague region, including Rejuran, Profhilo, Gouri, Radiesse, HArmoniCa, Plenhyage, Hyalift 75Pro, and Vitaran. These injectables stimulate the skin's own collagen and elastin production from within — unlike conventional fillers which simply add volume, biostimulators trigger biological regeneration and tissue remodelling. Sessions take 20–30 minutes with no downtime; effects develop over 4–6 weeks and last 6–18 months.

Biostimulators and collagen stimulators are a distinct category of injectable skin treatment that activate endogenous regenerative processes rather than merely replacing lost volume. At Lili Clinic, the range covers several distinct biological mechanisms: **PDRN (Polynucleotide) products — Rejuran, Plenhyage, Vitaran:** These products contain polydeoxyribonucleotides derived from salmon DNA, which are highly compatible with human tissue. PDRN activates A2A adenosine receptors, promoting cell proliferation, fibroblast recruitment, and collagen synthesis. Rejuran (2 ml face, 8,500 CZK) is the flagship Korean product in this category. Plenhyage (face 5,900 CZK; eye area 3,000 CZK) and Vitaran (eye area 3,000 CZK) are its Italian counterparts. All are used for facial skin quality improvement, deep hydration, and fine wrinkle treatment. **HA bioremodelling — Profhilo, Hyalift 75Pro:** Profhilo (5,900 CZK) contains a uniquely high concentration of hyaluronic acid (64 mg/2 ml) in both high-MW and low-MW forms. Rather than creating lift or volume, it remodels the skin architecture, improving elasticity and hydration across a wider tissue area via controlled enzymatic spreading. Hyalift 75Pro (5,500 CZK) provides similar bio-remodelling with a crosslinked HA matrix. **Calcium hydroxyapatite — Radiesse, HArmoniCa:** Radiesse (one area, 10,500 CZK) uses CaHA microspheres suspended in a gel carrier. The gel provides immediate structural support while the microspheres stimulate fibroblast activity for collagen production; the carrier is absorbed and CaHA is metabolised over 12–18 months. HArmoniCa (18,000 CZK) is a hybrid of HA gel and CaHA, combining immediate volume with long-duration biostimulation. **PCL — Gouri:** Gouri (8,500 CZK) is an injectable liquid polycaprolactone — the only truly liquid collagen stimulator — that distributes evenly throughout the dermis before triggering a sustained multi-year collagen production response. All biostimulator treatments take 20–30 minutes. Return to normal activities is immediate. Effects develop progressively over 4–6 weeks and last 6–18 months. A course of 3–4 sessions at 2–3 week intervals is standard for first-time treatment.