Type
Mesotherapy
Duration
45 min
What's included
3 deliverables in this treatment
- Physician-administered PDRN injection (MUDr. Bednář)
- Three-component formula: PDRN + hyaluronic acid + Niacinamide (Vitamin B3)
- Post-injection assessment and aftercare guidance
PDRN polynucleotide injections at Laserstudio deliver a bio-regenerative compound derived from salmon DNA — polydeoxyribonucleotides (PDRN) combined with hyaluronic acid and Niacinamide (Vitamin B3) — into the dermis to activate growth factor pathways, support cell and tissue renewal, and progressively slow visible ageing. The salmon-derived PDRN fragments bind to A2 adenosine receptors in skin cells, stimulating DNA repair mechanisms, collagen synthesis, and angiogenesis. The addition of hyaluronic acid provides simultaneous hydration and volume support, while Niacinamide targets pigmentation and barrier function. Results become visible within days of the first session and continue to improve with additional treatments. The compound supports elasticity, hydration, wrinkle reduction, pigmentation correction, and improvement of acne and scar tissue.
About this treatment
PDRN (polydeoxyribonucleotide) therapy at Laserstudio is a physician-administered regenerative skin treatment that uses highly purified DNA fragments extracted from salmon (Oncorhynchus mykiss) sperm cells. The salmon DNA is processed to obtain PDRN — short oligonucleotide chains that are structurally analogous to human DNA building blocks, making them biocompatible and fully biodegradable.
The primary mechanism of action is the activation of A2 adenosine receptors on keratinocytes and fibroblasts. When PDRN binds to these receptors, it stimulates the secretion of vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and hepatocyte growth factor (HGF) — a cascade that promotes collagen type I synthesis, new blood vessel formation (angiogenesis), and accelerated cellular DNA repair. This makes PDRN particularly effective…
The formula used at Laserstudio combines PDRN with hyaluronic acid, which provides immediate biomechanical support and hydration by attracting water molecules to the dermis; and Niacinamide (Vitamin B3), which inhibits melanosome transfer from melanocytes to keratinocytes (reducing pigmentation), reinforces the skin's ceramide barrier, and modulates sebum production. The three-component cocktail addresses regeneration, hydration, and pigmentation…
Good to know
- Active ingredient
- PDRN from salmon DNA + HA + Niacinamide
- Mechanism
- A2 adenosine receptor activation → VEGF/FGF/HGF stimulation
- Results onset
- Visible within days
- Course
- 2–4 sessions initial; maintenance every 3–6 months
- Price
- 3 500 Kč per session
Who is this for?
Photoageing, skin laxity, dullness, pigmentation, acne or scar tissue, dehydrated skin; those seeking biological regeneration rather than volumising fillers
Preparation required
Avoid alcohol for 24 hours before the injection. Discontinue NSAIDs or aspirin (unless medically required) for 5–7 days before to reduce bruising risk. Arrive with clean skin. Avoid vigorous exercise for 24 hours after the session.
About the clinic
Reviews, team and credentials
Independent review links and clinic-reported team information.
Clinical team
MUDr. Rostislav Bednář is the lead dermatologist at Laserstudio and the sole named physician at the clinic. His profile on ZnamyLekar lists him as practicing at Zábřežská 41, Šumperk, where he has accumulated 12 patient reviews. He performs all injectable procedures (botulinum toxin, hyaluronic acid fillers, plasma lifting, PDRN injections, mesotherapy) as well as surgical removals of moles, atheromas, and skin…
Languages: Czech
What clients say
"{"author":"Stefan P.","procedure":"Pigmentation laser removal","text":"After years with brown spots on my face, I didn't know laser removal was possible. One procedure removed them completely. Doctor Bednář is very pleasant and human."}"
"{"author":"Verified patient","procedure":"Botulinum toxin — nasolabial folds","text":"I came for nasolabial wrinkle and botox treatment. The doctor is kind, empathetic, explained everything perfectly. Very human approach."}"
Treatment highlights
- Physician-administered PDRN injection (MUDr. Bednář)
- Three-component formula: PDRN + hyaluronic acid + Niacinamide (Vitamin B3)
+1 more item in What's included
3 500 Kč per session. Includes PDRN (polydeoxyribonucleotides from salmon DNA), hyaluronic acid, and Niacinamide (Vitamin B3) cocktail. Results visible within days. Typically 2–4 sessions for initial course.