PDRN Polynucleotide Skin Rejuvenation

PDRN polynucleotide injections at Laserstudio deliver a bio-regenerative compound derived from salmon DNA — polydeoxyribonucleotides (PDRN) combined with hyaluronic acid and Niacinamide (Vitamin B3) — into the dermis to activate growth factor pathways, support cell and tissue renewal, and progressively slow visible ageing. The salmon-derived PDRN fragments bind to A2 adenosine receptors in skin cells, stimulating DNA repair mechanisms, collagen synthesis, and angiogenesis. The addition of hyaluronic acid provides simultaneous hydration and volume support, while Niacinamide targets pigmentation and barrier function. Results become visible within days of the first session and continue to improve with additional treatments. The compound supports elasticity, hydration, wrinkle reduction, pigmentation correction, and improvement of acne and scar tissue.

PDRN (polydeoxyribonucleotide) therapy at Laserstudio is a physician-administered regenerative skin treatment that uses highly purified DNA fragments extracted from salmon (Oncorhynchus mykiss) sperm cells. The salmon DNA is processed to obtain PDRN — short oligonucleotide chains that are structurally analogous to human DNA building blocks, making them biocompatible and fully biodegradable. The primary mechanism of action is the activation of A2 adenosine receptors on keratinocytes and fibroblasts. When PDRN binds to these receptors, it stimulates the secretion of vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and hepatocyte growth factor (HGF) — a cascade that promotes collagen type I synthesis, new blood vessel formation (angiogenesis), and accelerated cellular DNA repair. This makes PDRN particularly effective for skin that has been compromised by photoageing, wound repair processes, or chronic inflammation. The formula used at Laserstudio combines PDRN with hyaluronic acid, which provides immediate biomechanical support and hydration by attracting water molecules to the dermis; and Niacinamide (Vitamin B3), which inhibits melanosome transfer from melanocytes to keratinocytes (reducing pigmentation), reinforces the skin's ceramide barrier, and modulates sebum production. The three-component cocktail addresses regeneration, hydration, and pigmentation simultaneously in a single injection session. The compound is administered by micro-injection into the mid-dermis in the target area. Visible improvement typically begins within several days as the cellular response is activated; a complete initial course of 2–4 sessions optimises outcomes, and maintenance sessions every 3–6 months sustain the collagen renewal process. The treatment is well tolerated — mild injection site reactions (temporary redness, pinpoint bruising) may occur, resolving within hours to days. It is suitable as a stand-alone treatment or as a complement to fractional laser or microneedling protocols.